Investigations into the antinociceptive activity of Sapindus trifoliatus in various pain models

The effect of the aqueous extract of Sapindus trifoliatus (ST) on chemical, thermal‐induced pain, nitroglycerin‐induced hyperalgesia and pain on inflamed tissue was investigated. The extract (20 and 100 mg kg−1, i.p.) significantly inhibited acetic‐acid‐induced abdominal constrictions, formalin‐induced pain licking and hotplate‐induced pain in mice. Furthermore, the extract significantly increased the response latencies of nitroglycerin‐induced hyperalgesia by the tail‐flick method and mechanical pain on carrageenan‐induced inflamed paw in rats. The data suggest that ST has an inhibitory activity on both peripheral and central pain mechanisms and has a modulatory role in NO‐mediated nociceptive transmission.

[1]  K. Omote,et al.  Activation of Peripheral NMDA–Nitric Oxide Cascade in Formalin Test , 2000, Anesthesiology.

[2]  T. Coderre,et al.  The utility of excitatory amino acid (EAA) antagonists as analgesic agents. I. Comparison of the antinociceptive activity of various classes of EAA antagonists in mechanical, thermal and chemical nociceptive tests , 1994, Pain.

[3]  T. Williams,et al.  Prostaglandins as Potentiators of Increased Vascular Permeability in Inflammation , 1973, Nature.

[4]  E. Eisenberg,et al.  The NMDA antagonist memantine blocks pain behavior in a rat model of formalin-induced facial pain , 1993, Pain.

[5]  M. Peck,et al.  Role of prostaglandin-mediated vasodilatation in inflammation , 1977, Nature.

[6]  S. Mense,et al.  The role of spinal nitric oxide in the control of spontaneous pain following nociceptive input. , 2000, Progress in brain research.

[7]  N. B. Eddy,et al.  Synthetic analgesics. II. Dithienylbutenyl- and dithienylbutylamines. , 1953, The Journal of pharmacology and experimental therapeutics.

[8]  W. A. Prado,et al.  The dual effect of a nitric oxide donor in nociception , 2001, Brain Research.

[9]  J. Schoenen,et al.  Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis , 2000, Neuroreport.

[10]  J. Olesen,et al.  Nitric oxide supersensitivity: a possible molecular mechanism of migraine pain. , 1993, Neuroreport.

[11]  R. Lo,et al.  A method for measurement of analgesic activity on inflamed tissue. , 1957 .

[12]  S. Kulkarni,et al.  Antinociceptive and anti-inflammatory effects of Tanacetum parthenium L. extract in mice and rats. , 1999, Journal of ethnopharmacology.

[13]  J. Olesen,et al.  Intravenous nitroglycerin as an experimental model of vascular headache. Basic characteristics , 1989, Pain.

[14]  S. Ferreira.  Prostaglandins, aspirin-like drugs and analgesia. , 1972, Nature: New biology.

[15]  L. Berrino,et al.  Antinociceptive effect in mice of intraperitoneal N‐methyl‐d‐aspartate receptor antagonists in the formalin test , 2003, European journal of pain.

[16]  W. Gray,et al.  Measurement of the analgesic efficacy and potency of pentazocine by the D'Amour and Smith method. , 1970, The Journal of pharmacology and experimental therapeutics.

[17]  S. Hunskaar,et al.  The formalin test: an evaluation of the method , 1992, Pain.

[18]  J. Calixto,et al.  Antinociceptive profile of the pseudopeptide B2 bradykinin receptor antagonist NPC 18688 in mice , 1996, British journal of pharmacology.

[19]  A. Gomes,et al.  Antiinflammatory effect of petroleum ether extract of leaves of Litchi chinensis Gaertn. (Sapindaceae). , 1996, Journal of ethnopharmacology.

[20]  Fred E. D'Amour,et al.  A METHOD FOR DETERMINING LOSS OF PAIN SENSATION , 1941 .

[21]  S. Carlton,et al.  Intraplantar injection of dextrorphan, ketamine or memantine attenuates formalin-induced behaviors , 1998, Brain Research.

[22]  Janssen Pa,et al.  The inhibitory effect of fentanyl and other morphine-like analgesics on the warm water induced tail withdrawl reflex in rats. , 1963 .

[23]  H. Suh,et al.  Antinociceptive mechanisms of dipsacus saponin C administered intrathecally in mice. , 2000, Journal of ethnopharmacology.

[24]  J. Olesen,et al.  Headache provocation by continuous intravenous infusion of histamine. Clinical results and receptor mechanisms , 1980, Pain.

[25]  R. Yunes,et al.  Potent Antinociceptive Activity of a Hydroalcoholic Extract of Phyllanthus corcovadensis , 1993, The Journal of pharmacy and pharmacology.

[26]  J. Haley,et al.  Involvement of nitric oxide in spinally mediated hyperalgesia in the mouse , 1992, Neuroscience Letters.

[27]  R. Yunes,et al.  Analgesic Effects of Callus Culture Extracts from Selected Species of Phyllanthus in Mice , 1994, The Journal of pharmacy and pharmacology.

[28]  K. Omote,et al.  Formalin-induced release of excitatory amino acids in the skin of the rat hindpaw , 1998, Brain Research.

[29]  P. D’Aquila,et al.  (-)-Linalool produces antinociception in two experimental models of pain. , 2003, European journal of pharmacology.

[30]  S. Dohi,et al.  Spinal antinociceptive effect of epidural nonsteroidal antiinflammatory drugs on nitric oxide-induced hyperalgesia in rats. , 1999, Anesthesiology.

[31]  K. Budd.  Analgesic drugs. , 1981, Pharmacology & therapeutics.

[32]  Kjell Hole,et al.  The formalin test in mice: dissociation between inflammatory and non-inflammatory pain , 1987, Pain.

[33]  L. O. Randall,et al.  A method for measurement of analgesic activity on inflamed tissue. , 1957, Archives internationales de pharmacodynamie et de therapie.

[34]  Kyung-Tae Lee,et al.  Antinociceptive and anti-rheumatoidal effects of Kalopanax pictus extract and its saponin components in experimental animals. , 2002, Journal of ethnopharmacology.

[35]  R. Ghaly.  Pain Medicine—A Comprehensive Review , 2003 .

[36]  G. Nappi,et al.  Nitroglycerin induces hyperalgesia in rats--a time-course study. , 2003, European journal of pharmacology.

[37]  U. Scapagnini,et al.  Gangliosides antinociceptive effects in rodents. , 1984, Archives internationales de pharmacodynamie et de therapie.

[38]  R. F. Westbrook,et al.  The formalin test: scoring properties of the first and second phases of the pain response in rats , 1995, Pain.

[39]  C. Tassorelli,et al.  Systemic nitroglycerin induces Fos immunoreactivity in brainstem and forebrain structures of the rat , 1995, Brain Research.