An international comparison of sectoral knowledge bases: persistence and integration in the pharmaceutical industry

Abstract This paper builds upon and extends existing studies of scientific and technological specialisation by proposing an analytical framework to compare sectoral knowledge bases across countries. It develops the concepts of knowledge persistence and knowledge integration as the relevant dimensions along which knowledge bases can be compared. Persistence is studied by analysing the evolution of specialisation over time. It hints at the cumulative, path dependent nature of learning processes. Integration is studied by analysing the evolution of specialisation across different typologies of research. It hints at the complex, non-linear interdependencies that link the scientific and technological domains. On the strength of an original database encompassing 630,000 peer-reviewed papers published between 1989 and 1996 in 11 chemistry and pharmacology-related fields across three types of research (i.e. basic, applied and development), it is argued that countries with high degrees of both persistence and integration (e.g. the US in pharmacology) are the most likely sources of useful research results for EU firms’ innovative efforts in the pharmaceutical sector. Also, some doubts are cast on the existence of a European paradox in pharmaceuticals.

[1]  Daniele Archibugi,et al.  Specialization and size of scientific activities: A bibliometric analysis of advanced countries , 2005, Scientometrics.

[2]  John Cantwell,et al.  Technological Innovation and Multinational Corporations , 1989 .

[3]  R. Merton.  On the Shoulders of Giants: A Shandean Postscript , 1966 .

[4]  Aldo Geuna,et al.  Science-Technology Linkages in an Emerging Research Platform: The Case of Combinatorial Chemistry and Biology , 2004, Scientometrics.

[5]  Francis Narin,et al.  Bibliometric analysis of U.S. pharmaceutical industry research performance , 1988 .

[6]  K. Pavitt.  Technologies, Products and Organization in the Innovating Firm: What Adam Smith Tells Us and Joseph Schumpeter Doesn't , 1998 .

[7]  Gary P. Pisano,et al.  The Development Factory: Unlocking the Potential of Process Innovation , 1996 .

[8]  Anthony Arundel,et al.  Proximity and the use of public science by innovative European firms , 2004 .

[9]  Z. Ács,et al.  Regional Innovation, Knowledge and Global Change , 2001 .

[10]  Edwin Mansfield,et al.  Academic research and industrial innovation , 1991 .

[11]  Luigi Orsenigo,et al.  The emergence of biotechnology , 1989 .

[12]  Luc Soete,et al.  The impact of technological innovation on international trade patterns: The evidence reconsidered* , 1987 .

[13]  David C. Mowery,et al.  Technology and the Wealth of Nations , 1992 .

[14]  Keith Pavitt,et al.  National systems of innovation under strain: the internationalisation of corporate R&D. , 2000 .

[15]  K. Boulding.  Towards a new economics , 1992 .

[16]  D. Price.  Little Science, Big Science , 1965 .

[17]  James B. Conant,et al.  Harvard case histories in experimental science , 1957 .

[18]  D. Hicks.  Published Papers, Tacit Competencies and Corporate Management of the Public/Private Character of Knowledge , 1995 .

[19]  P. David,et al.  Toward a new economics of science , 1994 .

[20]  Andrea Prencipe,et al.  Technological competencies and product's evolutionary dynamics a case study from the aero-engine industry , 1997 .

[21]  Hariolf Grupp,et al.  The scientometric weight of 50 nations in 27 science areas, 1989–1993. Part I. All fields combined, mathematics, engineering, chemistry and physics , 2005, Scientometrics.

[22]  Marco Iansiti,et al.  Technology Integration: Making Critical Choices in a Dynamic World , 1997 .

[23]  Gary P. Pisano,et al.  Learning-before-doing in the development of new process technology , 1996 .

[24]  Daniele Archibugi,et al.  The Technological Specialization of Advanced Countries , 1992 .

[25]  Franco Malerba,et al.  Technological Regimes and Sectoral Patterns of Innovative Activities , 1997 .

[26]  Stephen Pumphrey,et al.  The technological specialisation of advanced countries: Daniele Archibugi and Mario Pianta 164 pages, £48.00, Dordrecht, Kluwer Academic Publishers, 1992☆ , 1994 .

[27]  Aldo Geuna.  Evolution of specialisation: public research in the chemical and pharmaceutical industries , 2001 .

[28]  The Economic Challenge for Europe , 1999 .

[29]  Dominique Foray,et al.  Organisation for Economic Co-operation and Development Directorate for Science, Technology and Industry Committee for Scientific and Technological Policy Dsti/stp/tip(94)4 Working Group on Innovation and Technology Policy Accessing and Expanding the Science and Technology Knowledge Base Complete Doc , 2022 .

[30]  Kimberly S. Hamilton,et al.  The increasing linkage between U.S. technology and public science , 1997 .

[31]  P. David.  Clio and the Economics of QWERTY , 1985 .

[32]  Robert J. W. Tijssen,et al.  In search of the European Paradox: an international comparison of Europe's scientific performance and knowledge flows in information and communication technologies research , 1999 .

[33]  O. Granstrand,et al.  Multi-Technology Corporations: Why They Have “Distributed” Rather Than “Distinctive Core” Competencies , 1997 .

[34]  Walter G. Vincenti,et al.  What Engineers Know and How They Know It: Analytical Studies from Aeronautical History. , 1992 .

[35]  Gert Villumsen,et al.  Structural Change in OECD Export Specialisation Patterns: de-specialisation and 'stickiness' , 1998 .

[36]  Luigi Orsenigo,et al.  The Emergence of Biotechnology: Institutions and Markets in Industrial Innovation , 1989 .

[37]  Bo Carlsson,et al.  Technological Systems and Industrial Dynamics , 1997 .

[38]  Valentina Meliciani.  Technology, Trade and Growth in OECD Countries: Does Specialisation Matter? , 2001 .

[39]  Keith Pavitt,et al.  Uneven (and Divergent) Technological Accumulation among Advanced Countries: Evidence and a Framework of Explanation , 1994 .

[40]  B. Balassa.  Trade Liberalisation and “Revealed” Comparative Advantage , 1965 .

[41]  Keith Pavitt,et al.  Key Characteristics of the Large Innovating Firm , 1991 .

[42]  Walter G. Vincenti,et al.  What Engineers Know and How They Know It: Analytical Studies from Aeronautical History , 1990 .

[43]  B. Lundvall.  National Systems of Innovation , 1992 .

[44]  Stefano Brusoni,et al.  The knowledge bases of the world’s largest pharmaceutical groups: what do patent citations to non-patent literature reveal? , 2005 .

[45]  Nathan Rosenberg,et al.  Exploring the Black Box: Technology, Economics, and History , 1994 .

[46]  Mary O'Mahony,et al.  Productivity, Innovation and Economic Performance , 2000 .