Predictive model for estimating risk of crush syndrome: a data mining approach.

BACKGROUND There is no standard triage method for earthquake victims with crush injuries because of a scarcity of epidemiologic and quantitative data. We conducted a retrospective cohort study to develop predictive models based on clinical data for crush injury in the Kobe earthquake. METHODS The medical records of 372 patients with crush injuries from the Kobe earthquake were retrospectively analyzed. Twenty-one risk factors were assessed with logistic regression analysis for three outcomes relating to crush syndrome. Two types of predictive triage models--initial evaluation in the field and secondary assessment at the hospital--were developed using logistic regression analysis. Classification accuracy, Brier score and area under the receiver operating characteristic curve (AUC) were used to evaluate the model. RESULTS The initial triage model, which includes pulse rate, delayed rescue, and abnormal urine color, has an AUC of 0.73. The secondary model, which includes WBC, tachycardia, abnormal urine color, and hyperkalemia, shows an AUC of 0.76. CONCLUSIONS These triage models may be especially useful to nondisaster experts for distinguishing earthquake victims at high risk of severe crush syndrome from those at lower risk. Application of the model may allow relief workers to better utilize limited medical and transportation resources in the aftermath of a disaster.

[1]  Blaz Zupan,et al.  Orange: From Experimental Machine Learning to Interactive Data Mining , 2004, PKDD.

[2]  Jason E. Smith,et al.  Crush injury and crush syndrome: a review. , 2003, The Journal of trauma.

[3]  R. Vanholder,et al.  Renal replacement therapies in the aftermath of the catastrophic Marmara earthquake. , 2002, Kidney international.

[4]  R. Vanholder,et al.  Clinical findings in the renal victims of a catastrophic disaster: the Marmara earthquake. , 2002, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.

[5]  R. Vanholder,et al.  Acute renal failure due to crush syndrome during Marmara earthquake. , 2002, American journal of kidney diseases : the official journal of the National Kidney Foundation.

[6]  R. Vanholder,et al.  Treatment Modalities and Outcome of the Renal Victims of the Marmara Earthquake , 2002, Nephron.

[7]  K. Shu,et al.  Clinical features and outcome of crush syndrome caused by the Chi-Chi earthquake. , 2002, Journal of the Formosan Medical Association = Taiwan yi zhi.

[8]  R. Vanholder,et al.  Intervention of the Renal Disaster Relief Task Force in the 1999 Marmara, Turkey earthquake. , 2001, Kidney international.

[9]  Frank E. Harrell,et al.  Regression Modeling Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis , 2001 .

[10]  T. Shimazu,et al.  Morbidity and mortality of hospitalized patients after the 1995 Hanshin-Awaji earthquake. , 1999, The American journal of emergency medicine.

[11]  D. Margolis,et al.  Validation of a melanoma prognostic model. , 1998, Archives of dermatology.

[12]  R. Mullins,et al.  Rhabdomyolysis and myoglobinuric renal failure in trauma and surgical patients: a review. , 1998, Journal of the American College of Surgeons.

[13]  T. Shimazu,et al.  Overview of evacuation and transport of patients following the 1995 Hanshin-Awaji earthquake. , 1998, The Journal of emergency medicine.

[14]  S. Nishi,et al.  Crush syndrome sustained in the 1995 Kobe, Japan, earthquake; treatment and outcome. , 1997, Annals of emergency medicine.

[15]  T. Shimazu,et al.  Analysis of 2,702 traumatized patients in the 1995 Hanshin-Awaji earthquake. , 1997, The Journal of trauma.

[16]  T. Shimazu,et al.  Fluid resuscitation and systemic complications in crush syndrome: 14 Hanshin-Awaji earthquake patients. , 1997, The Journal of trauma.

[17]  T. Shimazu,et al.  Analysis of 372 patients with Crush syndrome caused by the Hanshin-Awaji earthquake. , 1997, The Journal of trauma.

[18]  M. Michaelson Crush injury and crush syndrome , 1992, World Journal of Surgery.

[19]  F. Rosner,et al.  Rhabdomyolysis: report of eleven cases. , 1992, Journal of the National Medical Association.

[20]  D. Hosmer,et al.  Applied Logistic Regression , 1991 .

[21]  David Crippen,et al.  Disaster Reanimatology Potentials: A Structured Interview Study in Armenia. III. Results, Conclusions, and Recommendations , 1991, Prehospital and Disaster Medicine.

[22]  M. Odeh The role of reperfusion-induced injury in the pathogenesis of the crush syndrome. , 1991, The New England journal of medicine.

[23]  E. Noji Prophylaxis of acute renal failure in traumatic rhabdomyolysis. , 1990, The New England journal of medicine.

[24]  J. H. Stein,et al.  Early management of shock and prophylaxis of acute renal failure in traumatic rhabdomyolysis. , 1990, The New England journal of medicine.

[25]  J. Minei,et al.  Role of leukocytes in reperfusion injury of skeletal muscle after partial ischemia. , 1989, The American journal of physiology.

[26]  D. Granger,et al.  Mechanisms of cellular injury: potential sources of oxygen free radicals in ischemia/reperfusion. , 1989, Microcirculation, endothelium, and lymphatics.

[27]  M. Ward Factors predictive of acute renal failure in rhabdomyolysis. , 1988, Archives of internal medicine.

[28]  Sheng Zhi-Yong,et al.  Medical support in the Tangshan earthquake: a review of the management of mass casualties and certain major injuries. , 1987 .

[29]  S. Bursztein,et al.  Management of crush syndrome. , 1984, Resuscitation.

[30]  S. Bursztein,et al.  Prevention of acute renal failure in traumatic rhabdomyolysis. , 1984, Archives of internal medicine.

[31]  J. Hanley,et al.  A method of comparing the areas under receiver operating characteristic curves derived from the same cases. , 1983, Radiology.

[32]  J. Hanley,et al.  The meaning and use of the area under a receiver operating characteristic (ROC) curve. , 1982, Radiology.

[33]  G. Romano,et al.  A study of the pathology of the crush syndrome. , 1982, Surgery, gynecology & obstetrics.

[34]  J. Lubsen,et al.  A Practical Device for the Application of a Diagnostic or Prognostic Function , 1978, Methods of Information in Medicine.

[35]  T. Ohwada,et al.  Rapid fall in blood myoglobin in massive rhabdomyolysis and acute renal failure , 2005, Intensive Care Medicine.

[36]  E. Noji Acute renal failure in natural disasters. , 1992, Renal failure.

[37]  O. Better The crush syndrome revisited (1940-1990). , 1990, Nephron.

[38]  G. V. van Ommen,et al.  Report of the committee on the genetic constitution of chromosome 4. , 1990, Cytogenetics and cell genetics.

[39]  R. Korthuis,et al.  Hypoxic reperfusion attenuates postischemic microvascular injury. , 1989, The American journal of physiology.

[40]  P. Barry,et al.  Earthquake disaster in Nicaragua: reflections on the initial management of massive casualties. , 1974, The Journal of trauma.

[41]  G. Brier VERIFICATION OF FORECASTS EXPRESSED IN TERMS OF PROBABILITY , 1950 .