Point-of-Care Periodontitis Testing: Biomarkers, Current Technologies, and Perspectives.

[1]  J. Chun,et al.  Pyrosequencing Analysis of Subgingival Microbiota in Distinct Periodontal Conditions , 2015, Journal of dental research.

[2]  T. Lu,et al.  Paper: A promising material for human-friendly functional wearable electronics , 2017 .

[3]  Craig S. Miller,et al.  Patterns of Salivary Analytes Provide Diagnostic Capacity for Distinguishing Chronic Adult Periodontitis from Health , 2012, Journal of Clinical Immunology.

[4]  Karthik Venkataraghavan,et al.  Estimation Of Tumour Necrosis Factor-Alpha Levels In Gingival Crevicular Fluid In Periodontal Health And Disease In An Indian Population-A Clinical And Biochemical Study , 2011 .

[5]  Yusuke Kuroki,et al.  Mouthguard biosensor with telemetry system for monitoring of saliva glucose: A novel cavitas sensor. , 2016, Biosensors & bioelectronics.

[6]  W. Scarfe,et al.  The emerging role of maxillofacial radiology in the diagnosis and management of patients with complex periodontitis. , 2017, Periodontology 2000.

[7]  P. Preshaw,et al.  Salivary cytokines as biomarkers of periodontal diseases. , 2016, Periodontology 2000.

[8]  Amy E Herr,et al.  Integrated Microfluidic Platform for Oral Diagnostics , 2007, Annals of the New York Academy of Sciences.

[9]  Martha E. Grady,et al.  The periodontal war: microbes and immunity , 2017, Periodontology 2000.

[10]  A. Braga,et al.  Clinical improvement following therapy for periodontitis: Association with a decrease in IL-1 and IL-6 , 2014, Experimental and therapeutic medicine.

[11]  Richard Bruch,et al.  Multiplexed Point-of-Care Testing – xPOCT , 2017, Trends in biotechnology.

[12]  E. Lesaffre,et al.  Diagnostic accuracy for apical and chronic periodontitis biomarkers in gingival crevicular fluid: an exploratory study. , 2016, Journal of clinical periodontology.

[13]  A. Saito,et al.  Evaluation of a novel immunochromatographic device for rapid and accurate clinical detection of Porphyromonas gingivalis in subgingival plaque. , 2015, Journal of microbiological methods.

[14]  Jie Hu,et al.  Improved LFIAs for highly sensitive detection of BNP at point-of-care , 2017, International journal of nanomedicine.

[15]  Y. Izumi,et al.  Evaluation of bleeding on probing and gingival crevicular fluid enzyme activity for detection of periodontally active sites during supportive periodontal therapy , 2012, Odontology.

[16]  O. Shaker,et al.  Effect of Periodontal Surgery on Osteoprotegerin Levels in Gingival Crevicular Fluid, Saliva, and Gingival Tissues of Chronic Periodontitis Patients , 2015, Disease markers.

[17]  Youngnim Choi,et al.  Point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge , 2015, Front. Cell. Infect. Microbiol..

[18]  R. F. de Albuquerque,et al.  Levels of aspartate aminotransferase (AST) in saliva of patients with different periodontal conditions. , 2003, Journal of clinical periodontology.

[19]  Y. Hiroshima,et al.  Determination of calprotectin in gingival crevicular fluid by immunoassay on a microchip. , 2012, Clinical biochemistry.

[20]  D. Gillam,et al.  Accuracy and reproducibility of probe forces during simulated periodontal pocket depth measurements. , 2014, The Saudi dental journal.

[21]  S. Ivanovski,et al.  Mechanisms of Bone Resorption in Periodontitis , 2015, Journal of immunology research.

[22]  Mohammed Zourob,et al.  Colorimetric Assay for the Detection of Typical Biomarkers for Periodontitis Using a Magnetic Nanoparticle Biosensor. , 2015, Analytical chemistry.

[23]  S. Holt,et al.  Acquisition of Oral Microbes and Associated Systemic Responses of Newborn Nonhuman Primates , 2013, Clinical and Vaccine Immunology.

[24]  Hassan Hajghassem,et al.  Point of care testing: The impact of nanotechnology. , 2017, Biosensors & bioelectronics.

[25]  G. Seymour,et al.  Periodontopathogen levels following the use of an Er:YAG laser in the treatment of chronic periodontitis. , 2016, Australian dental journal.

[26]  Aydogan Ozcan,et al.  Emerging Technologies for Next-Generation Point-of-Care Testing. , 2015, Trends in biotechnology.

[27]  Craig S. Miller,et al.  Lab‐on‐a‐Chip Methods for Point‐of‐Care Measurements of Salivary Biomarkers of Periodontitis , 2007, Annals of the New York Academy of Sciences.

[28]  P. Miethe,et al.  Immunoassay‐Based Diagnostic Point‐of‐Care Technology for Oral Specimen , 2007, Annals of the New York Academy of Sciences.

[29]  C. Douglas,et al.  A pilot study of active enzyme levels in gingival crevicular fluid of patients with chronic periodontal disease. , 2016, Journal of clinical periodontology.

[30]  M. Leon,et al.  Periodontal disease associates with higher brain amyloid load in normal elderly , 2015, Neurobiology of Aging.

[31]  E. Ademoglu,et al.  Is the severity of periodontitis related to gingival crevicular fluid and serum high-sensitivity C-reactive protein concentrations? , 2014, Clinical laboratory.

[32]  J. Slots.  Periodontitis: facts, fallacies and the future. , 2017, Periodontology 2000.

[33]  Aravind Kumar,et al.  Chairside diagnostics in periodontics , 2017 .

[34]  A. Palmieri,et al.  QUANTITATIVE ANALYSIS OF PERIODONTAL PATHOGENS IN PERIODONTITIS AND GINGIVITIS. , 2015, Journal of biological regulators and homeostatic agents.

[35]  M. Barton.  Evidence accumulates indicating periodontal disease as a risk factor for colorectal cancer or lymphoma , 2017, CA: a cancer journal for clinicians.

[36]  Fei Li,et al.  Advances in paper-based point-of-care diagnostics. , 2014, Biosensors & bioelectronics.

[37]  R. Mohan,et al.  Diagnostic Accuracy of CBCT for Aggressive Periodontitis , 2014, Journal of clinical imaging science.

[38]  P. Papapanou,et al.  Periodontal diseases , 2017, Nature Reviews Disease Primers.

[39]  R. Soman,et al.  Estimation of Specific Salivary Enzymatic Biomarkers in Individuals with Gingivitis and Chronic Periodontitis: A Clinical and Biochemical Study , 2015, Journal of international oral health : JIOH.

[40]  N. Suzuki,et al.  Mixed Red-Complex Bacterial Infection in Periodontitis , 2013, International journal of dentistry.

[41]  P. Eke,et al.  Standards for reporting chronic periodontitis prevalence and severity in epidemiologic studies: Proposed standards from the Joint EU/USA Periodontal Epidemiology Working Group. , 2015, Journal of clinical periodontology.

[42]  K. Tabeta,et al.  Profiling biomarkers in gingival crevicular fluid using multiplex bead immunoassay. , 2013, Archives of oral biology.

[43]  T. Sheth,et al.  Analysis of aspartate aminotransferase in gingival crevicular fluid: A study with initial therapy , 2011, Journal of Indian Society of Periodontology.

[44]  M. Enăchescu,et al.  New sensor based on membranes with magnetic nano-inclusions for early diagnosis in periodontal disease. , 2018, Biosensors & bioelectronics.

[45]  M. Syczewska,et al.  Relationship between clinical parameters and cytokine profiles in inflamed gingival tissue and serum samples from patients with chronic periodontitis. , 2003, Journal of clinical periodontology.

[46]  D. Kinane,et al.  The relationship between elastase and lactoferrin in healthy, gingivitis and periodontitis sites. , 2008, Oral diseases.

[47]  J. Kinney,et al.  Personalized medicine: an update of salivary biomarkers for periodontal diseases. , 2016, Periodontology 2000.

[48]  Emanuel Carrilho,et al.  Determination of nitrite in saliva using microfluidic paper-based analytical devices. , 2014, Analytica chimica acta.

[49]  G. Urban,et al.  Biosensors and personalized drug therapy: what does the future hold? , 2017 .

[50]  T. Braun,et al.  Crevicular fluid biomarkers and periodontal disease progression. , 2014, Journal of Clinical Periodontology.

[51]  I. Lamster,et al.  GCF IL-1β profiles in periodontal disease , 2002 .

[52]  C. Murray,et al.  Global Burden of Severe Periodontitis in 1990-2010 , 2014, Journal of dental research.

[53]  T. Salo,et al.  Gingival crevicular fluid collagenase-2 (MMP-8) test stick for chair-side monitoring of periodontitis. , 2003, Journal of periodontal research.

[54]  Sheetal Sanikop,et al.  Gingival crevicular fluid alkaline phosphatase as a potential diagnostic marker of periodontal disease , 2012, Journal of Indian Society of Periodontology.

[55]  Joseph Wang,et al.  Wearable salivary uric acid mouthguard biosensor with integrated wireless electronics. , 2015, Biosensors & bioelectronics.

[56]  A. Gustafsson,et al.  Granulocyte elastase in gingival crevicular fluid. A possible discriminator between gingivitis and periodontitis. , 1992, Journal of clinical periodontology.

[57]  J. Gamonal,et al.  Matrix metalloproteinases and myeloperoxidase in gingival crevicular fluid provide site-specific diagnostic value for chronic periodontitis. , 2014, Journal of clinical periodontology.

[58]  M. Feres,et al.  Newly Identified Pathogens Associated with Periodontitis , 2014, Journal of dental research.

[59]  E. Reynolds,et al.  Rapid Chair-Side Test for Detection of Porphyromonas gingivalis , 2017, Journal of dental research.

[60]  A. Manz,et al.  Miniaturized total chemical analysis systems: A novel concept for chemical sensing , 1990 .

[61]  A. Acevedo,et al.  Host-derived salivary biomarkers in diagnosing periodontal disease: systematic review and meta-analysis. , 2016, Journal of clinical periodontology.

[62]  H. Newman,et al.  Obesity, diabetes mellitus, atherosclerosis and chronic periodontitis: a shared pathology via oxidative stress and mitochondrial dysfunction? , 2014, Periodontology 2000.

[63]  Fei Li,et al.  Pen-on-paper strategy for point-of-care testing: Rapid prototyping of fully written microfluidic biosensor. , 2017, Biosensors & bioelectronics.

[64]  E. E. Sakallıoğlu,et al.  Effect of bisphosphonate as an adjunct treatment for chronic periodontitis on gingival crevicuar fluid levels of nuclear factor-κB ligand (RANKL) and osteoprotegerin in postmenopausal osteoporosis. , 2017, Journal of oral science.

[65]  F. Teles,et al.  Levels of Candidate Periodontal Pathogens in Subgingival Biofilm , 2016, Journal of dental research.

[66]  J. Gooty,et al.  Chair side diagnostic test kits in periodontics , 2015 .

[67]  G. K. Johnson,et al.  A multiplex immunoassay demonstrates reductions in gingival crevicular fluid cytokines following initial periodontal therapy. , 2010, Journal of periodontal research.

[68]  Y. Nomura,et al.  Chair-side detection of Prevotella Intermedia in mature dental plaque by its fluorescence. , 2017, Photodiagnosis and photodynamic therapy.

[69]  Timo Sorsa,et al.  Salivary Diagnostics—Point-of-Care diagnostics of MMP-8 in dentistry and medicine , 2017, Diagnostics.

[70]  Sachin Malagi.  CHAIRSIDE DIAGNOSTIC TEST KITS IN PERIODONTICS - A REVIEW , 2012 .

[71]  Feng Xu,et al.  Nanomaterial- and Micromaterial-Based Immunoassays , 2018 .

[72]  T. Morelli,et al.  Gingival crevicular fluid as a source of biomarkers for periodontitis. , 2016, Periodontology 2000.

[73]  Wenzhao Jia,et al.  Non-invasive mouthguard biosensor for continuous salivary monitoring of metabolites. , 2014, The Analyst.

[74]  Nitin Gupta,et al.  Comparative evaluation of accuracy of periodontal probing depth and attachment levels using a Florida probe versus traditional probes. , 2015, Medical journal, Armed Forces India.

[75]  Y. Nomura,et al.  Screening of periodontitis with salivary enzyme tests. , 2006, Journal of oral science.

[76]  M. Kiran,et al.  Cone Beam Computed Tomography - Know its Secrets , 2015, Journal of international oral health : JIOH.

[77]  Masato Saito,et al.  Quantitative Detection for Porphyromonas gingivalis in Tooth Pocket and Saliva by Portable Electrochemical DNA Sensor Linked with PCR , 2014 .

[78]  K. Kamburoğlu,et al.  Use of cone beam computed tomography in periodontology. , 2014, World journal of radiology.

[79]  Hadley D Sikes,et al.  Detection of Biomarkers of Periodontal Disease in Human Saliva Using Stabilized, Vertical Flow Immunoassays. , 2017, ACS sensors.

[80]  T. Mulli,et al.  Association of salivary RANKL and osteoprotegerin levels with periodontal health , 2017, Clinical and experimental dental research.

[81]  K. Torrungruang,et al.  Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, and Treponema denticola / Prevotella intermedia Co-Infection Are Associated with Severe Periodontitis in a Thai Population , 2015, PloS one.

[82]  J. Popp,et al.  On site visual detection of Porphyromonas gingivalis related periodontitis by using a magnetic-nanobead based assay for gingipains protease biomarkers , 2018, Microchimica Acta.

[83]  G. Hajishengallis,et al.  Periodontitis: from microbial immune subversion to systemic inflammation , 2014, Nature Reviews Immunology.

[84]  L. Busch,et al.  Salivary IL-1β and PGE2 as biomarkers of periodontal status, before and after periodontal treatment. , 2013, Journal of clinical periodontology.

[85]  Min-Gon Kim,et al.  Vertical flow immunoassay (VFA) biosensor for a rapid one-step immunoassay. , 2013, Lab on a chip.

[86]  P. Eke,et al.  Update on Prevalence of Periodontitis in Adults in the United States: NHANES 2009 to 2012. , 2015, Journal of periodontology.

[87]  Dengfeng Gao,et al.  Household Fluorescent Lateral Flow Strip Platform for Sensitive and Quantitative Prognosis of Heart Failure Using Dual-Color Upconversion Nanoparticles. , 2017, ACS nano.

[88]  P. M. Kumar,et al.  Estimation of prostaglandin E2 levels in gingival crevicular fluid in periodontal health, disease and after treatment , 2013, Contemporary clinical dentistry.

[89]  M. R. Gatto,et al.  Prevalence of six periodontal pathogens in subgingival samples of Italian patients with chronic periodontitis. , 2014, The new microbiologica.

[90]  Jin-Woo Choi,et al.  Point-of-care testing (POCT) diagnostic systems using microfluidic lab-on-a-chip technologies , 2015 .

[91]  Identification of pathogen and host-response markers correlated with periodontal disease. , 2009 .

[92]  Comparison of periodontal evaluation by cone-beam computed tomography, and clinical and intraoral radiographic examinations , 2018, Oral Radiology.

[93]  D. Kuhlmeier,et al.  T E C H N I C a L a D V a N C E Open Access Development of a Point-of-care-device for Fast Detection of Periodontal Pathogens , 2022 .