Piperoxan hydrochloride (benzodioxan) test; report of a false positive reaction.

The response to piperoxan hydrochloride (benzodioxan) was first described as a diagnostic test for patients with sustained hypertension associated with pheochromocytoma inThe Journalin 1947.1Since that time, the test has been generally accepted. The rational use of this drug is based on its specificity for blocking circulating epinephrine, arterenol (norepinephrine) or related compounds. Patients with hypertension of other than the above origins have shown either no alteration or an elevation of the blood pressure when piperoxan hydrochloride has been given intravenously.2There have been three cases reported of patients who demonstrated a normal response to the piperoxan hydrochloride test and were later shown to have pheochromocytomas.2d I have been able to find only one case of an unautopsied patient who was reported by Taliaferro to have false positive tests.3The diagnosis of renal hypertension in this case, however, has been questioned.2d The case

[1]  M. Goldenberg.  Adrenal medullary function. , 1951, The American journal of medicine.

[2]  G. Buck,et al.  A case of pheochromocytoma: diagnosis by the benzodioxane test, urinary hormone studies, and nor-epinephrine assay of the tumor. , 1950, The Journal of clinical endocrinology and metabolism.

[3]  M. Goldenberg,et al.  Diagnosis of pheochromocytoma by the adrenergic blocking action of benzodioxan. , 1950, Journal of the American Medical Association.

[4]  R. Wilkins,et al.  Extensive laboratory studies of a patient with pheochromocytoma before and after successful operation; with a note on the trial of piperidylmethyl benzodioxane to differentiate such conditions from essential hypertensive vascular disease. , 1950, Archives of internal medicine.

[5]  D. Green,et al.  Hypertensive encephalopathy after administration of benzodioxan. , 1950, Journal of the American Medical Association.

[6]  J. Miller,et al.  Streptomycin in the treatment of tuberculous tenosynovitis. , 1950, Journal of the American Medical Association.

[7]  V. Drill.  Reactions from the Use of Benzodioxane (933 F) in Diagnosis of Pheochromocytoma , 1949 .

[8]  H. B. Haag,et al.  Benzodioxan test; fall in blood pressure following its use in a case of renal hypertension. , 1949, Journal of the American Medical Association.

[9]  K. Grimson,et al.  Treatment of a patient with a pheochromocytoma; use of an adrenolytic drug before and during operation. , 1949, Journal of the American Medical Association.

[10]  M. Goldenberg,et al.  New test for hypertension due to circulating epinephrine. , 1947, Journal of the American Medical Association.