Effect of Biomaterial Surface Morphologies on Bone Marrow Cell Performance

The biological reaction on implant surfaces is of key importance for the integration of implants into the surrounding tissue. In the present study, a new set-up for the preparation of different surfaces with identical surface chemistry is presented. Using this technique, we investigated the effects of surface microstructuring on cell performance using adult, rat bone marrow cells as a tool. Our results indicate that cell morphology was strongly affected by the kind of surface microstructuring. Effects on cell culture biochemical characteristics did not always correlate with effects on cell morphology and cell culture appearance.

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