Mechanistic Features of Asymmetric Vinylidene ortho-Quinone Methide Construction and Subsequent Transformations

[1]  Jie Chen,et al.  Modular Construction of Heterobiaryl Atropisomers and Axially Chiral Styrenes via All-Carbon Tetrasubstituted VQMs. , 2022, Angewandte Chemie.

[2]  Xingguang Li,et al.  Quinone methides and indole imine methides as intermediates in enantioselective catalysis , 2022, Nature Synthesis.

[3]  Hailong Yan,et al.  Organocatalytic atroposelective construction of axially chiral N, N- and N, S-1,2-azoles through novel ring formation approach , 2022, Nature Communications.

[4]  C. Tung,et al.  Asymmetric Azide-Alkyne Cycloaddition with Ir(I)/Squaramide Cooperative Catalysis: Atroposelective Synthesis of Axially Chiral Aryltriazoles. , 2022, Journal of the American Chemical Society.

[5]  Hailong Yan,et al.  An Isolable Vinylidene ortho-Quinone Methide: Synthesis, Structure and Reactivity. , 2022, Angewandte Chemie.

[6]  Ying He,et al.  P-stereogenic N-vinylphosphonamides enabled by asymmetric allylic substitution-isomerization , 2021, Cell Reports Physical Science.

[7]  Hailong Yan,et al.  Diversity-oriented enantioselective construction of atropisomeric heterobiaryls and N-aryl indoles via vinylidene ortho-quinone methides (VQMs) , 2021 .

[8]  Hailong Yan,et al.  Organocatalytic enantioselective construction of chiral azepine skeleton bearing multiple-stereogenic elements. , 2021, Angewandte Chemie.

[9]  Ying He,et al.  Tandem Iridium Catalysis as a General Strategy for Atroposelective Construction of Axially Chiral Styrenes. , 2021, Journal of the American Chemical Society.

[10]  K. Tan,et al.  Enantioselective Synthesis of Axially Chiral Biaryls by Diels-Alder/Retro-Diels-Alder Reaction of 2-Pyrones with Alkynes. , 2021, Journal of the American Chemical Society.

[11]  D. Wei,et al.  Insights into the chiral sulfide/selenide-catalyzed electrophilic carbothiolation of alkynes: mechanism and origin of axial chirality , 2021 .

[12]  D. Wei,et al.  Origin and stabilization of axial chirality in the construction of naphthyl-C2-indoles: a DFT study , 2020 .

[13]  Chao‐Jun Li,et al.  Coupling without Coupling Reactions: En Route to Developing Phenols as Sustainable Coupling Partners via Dearomatization-Rearomatization Processes. , 2020, Accounts of chemical research.

[14]  P. Liu,et al.  Asymmetric allylic substitution–isomerization to axially chiral enamides via hydrogen-bonding assisted central-to-axial chirality transfer† , 2020, Chemical science.

[15]  B. Tan,et al.  Design and Atroposelective Construction of IAN analogues via Organocatalytic Asymmetric Heteroannulation of Alkynes. , 2020, Angewandte Chemie.

[16]  Hailong Yan,et al.  N-Iodosuccinimide-Mediated Dimerization of 2-Alkynylnaphthols: A Highly Diastereoselective Construction of Bridged Polycyclic Compounds via Vinylidene ortho-Quinone Methide Intermediate. , 2020, Organic letters.

[17]  Hailong Yan,et al.  Enantioselective control of both helical and axial stereogenic elements via an organocatalytic approach. , 2019, Angewandte Chemie.

[18]  Hailong Yan,et al.  Organocatalytic Asymmetric Annulation of ortho-Alkynylanilines: Synthesis of Axially Chiral Naphthyl-C2-Indoles. , 2019, Angewandte Chemie.

[19]  A. Matsumoto,et al.  Enantioselective bromination of axially chiral cyanoarenes in the presence of bifunctional organocatalysts , 2019, RSC advances.

[20]  Jean Rodriguez,et al.  Enantioselective organocatalytic activation of vinylidene-quinone methides (VQMs). , 2019, Chemical communications.

[21]  Hailong Yan,et al.  Hydrogen-bond-induced chiral axis construction: theoretical study of cinchonine-thiourea-catalyzed enantioselective intramolecular cycloaddition. , 2019, Chemistry, an Asian journal.

[22]  K. Houk,et al.  Rational design, enantioselective synthesis and catalytic applications of axially chiral EBINOLs , 2019, Nature Catalysis.

[23]  Yanli Zhao,et al.  Catalytic asymmetric acetalization of carboxylic acids for access to chiral phthalidyl ester prodrugs , 2019, Nature Communications.

[24]  R. Raines,et al.  Esterification Delivers a Functional Enzyme into a Human Cell. , 2019, ACS chemical biology.

[25]  Hailong Yan,et al.  Asymmetric One-Pot Construction of Three Stereogenic Elements: Chiral Carbon Center, Stereoisomeric Alkenes, and Chirality of Axial Styrenes. , 2018, Organic letters.

[26]  C. Nielsen,et al.  Visual kinetic analysis† †Electronic supplementary information (ESI) available: Microsoft Excel files with tutorials for VTNA and RPKA and a video available at https://youtu.be/5ORFRB4U10s. See DOI: 10.1039/c8sc04698k , 2018, Chemical science.

[27]  Hailong Yan,et al.  Organocatalytic Asymmetric One-Step Desymmetrizing Dearomatization Reaction of Indoles: Development and Bioactivity Evaluation. , 2018, Angewandte Chemie.

[28]  Hailong Yan,et al.  Enantioselective Construction of Vicinal Diaxial Styrenes and Multiaxis System via Organocatalysis. , 2018, Journal of the American Chemical Society.

[29]  Hailong Yan,et al.  Organocatalytic Atroposelective Intramolecular [4+2] Cycloaddition: Synthesis of Axially Chiral Heterobiaryls. , 2018, Angewandte Chemie.

[30]  Hailong Yan,et al.  Organocatalytic Enantioselective Construction of Axially Chiral Sulfone-Containing Styrenes. , 2018, Journal of the American Chemical Society.

[31]  Kazunobu Igawa,et al.  Vinylidene ortho-Quinone Methides: Unique Chiral Reaction Intermediates in Catalytic Asymmetric Synthesis. , 2018, Chimia.

[32]  Hailong Yan,et al.  Organocatalytic Intramolecular [4+2] Cycloaddition between In Situ Generated Vinylidene ortho-Quinone Methides and Benzofurans. , 2017, Angewandte Chemie.

[33]  R. Raines,et al.  Cytosolic Delivery of Proteins by Bioreversible Esterification. , 2017, Journal of the American Chemical Society.

[34]  J. Burés Variable Time Normalization Analysis: General Graphical Elucidation of Reaction Orders from Concentration Profiles. , 2016, Angewandte Chemie.

[35]  H. Schaefer,et al.  Electrophilic Aromatic Substitution: New Insights into an Old Class of Reactions. , 2016, Accounts of chemical research.

[36]  Rai‐Shung Liu,et al.  Recent Advances in Gold-Catalyzed N- and O-Functionalizations of Alkynes with Nitrones, Nitroso, Nitro and Nitroxy Species , 2016 .

[37]  J. Burés A Simple Graphical Method to Determine the Order in Catalyst , 2016, Angewandte Chemie.

[38]  K. Asano,et al.  Bifunctional organocatalysts for the enantioselective synthesis of axially chiral isoquinoline N-oxides. , 2015, Journal of the American Chemical Society.

[39]  T. Hashimoto,et al.  Recent advances of catalytic asymmetric 1,3-dipolar cycloadditions. , 2015, Chemical reviews.

[40]  T. Poulsen,et al.  Ester coupling reactions--an enduring challenge in the chemical synthesis of bioactive natural products. , 2015, Natural product reports.

[41]  Kun-Liang Wu,et al.  The Domestication of ortho-Quinone Methides , 2014, Accounts of chemical research.

[42]  Jeffrey S. Johnson,et al.  Dynamic kinetic asymmetric transformations of β-stereogenic α-ketoesters by direct aldolization. , 2014, Angewandte Chemie.

[43]  A. Sakakura,et al.  Enantioselective cyanoethoxycarbonylation of isatins promoted by a Lewis base-Brønsted acid cooperative catalyst. , 2013, Angewandte Chemie.

[44]  T. Kimachi,et al.  Organocatalyzed Isomerization of α‐Substituted Alkynoates into Trisubstituted Allenoates by Dynamic Kinetic Resolution , 2012 .

[45]  F. Doria,et al.  Vinylidene-quinone methides, photochemical generation and β-silicon effect on reactivity. , 2012, The Journal of organic chemistry.

[46]  K. Matsuzaki,et al.  Bifunctional hydrogen-bond donors that bear a quinazoline or benzothiadiazine skeleton for asymmetric organocatalysis. , 2011, Chemistry.

[47]  H. Pellissier Organocatalyzed Dynamic Kinetic Resolution , 2011 .

[48]  Scott J. Miller,et al.  Dynamic Kinetic Resolution of Biaryl Atropisomers via Peptide-Catalyzed Asymmetric Bromination , 2010, Science.

[49]  C. K. Andrade,et al.  3-arylamino and 3-alkoxy-nor-beta-lapachone derivatives: synthesis and cytotoxicity against cancer cell lines. , 2010, Journal of medicinal chemistry.

[50]  Lili Lin,et al.  Amide-based bifunctional organocatalysts in asymmetric reactions. , 2009, Chemical communications.

[51]  C. Song Cinchona Alkaloids in Synthesis and Catalysis , 2009 .

[52]  Xinhong Yu,et al.  Hydrogen-bond-mediated asymmetric catalysis. , 2008, Chemistry, an Asian journal.

[53]  F. Zaera,et al.  Competitive chemisorption between pairs of cinchona alkaloids and related compounds from solution onto platinum surfaces. , 2006, Journal of the American Chemical Society.

[54]  Mark S. Taylor,et al.  Asymmetric catalysis by chiral hydrogen-bond donors. , 2006, Angewandte Chemie.

[55]  Suaib Luqman,et al.  Synthesis of 1-(3',4',5'-trimethoxy) phenyl naphtho[2,1b]furan as a novel anticancer agent. , 2006, Bioorganic & medicinal chemistry letters.

[56]  E. Vedejs,et al.  Efficiency in nonenzymatic kinetic resolution. , 2005, Angewandte Chemie.

[57]  K. Fukumoto,et al.  A convenient method for the preparation of inverted tert-alkyl carboxylates from chiral tert-alcohols by a new type of oxidation-reduction condensation using 2,6-dimethyl-1,4-benzoquinone. , 2003, Journal of the American Chemical Society.

[58]  A. Baiker,et al.  Asymmetric hydrogenation on platinum: nonlinear effect of coadsorbed cinchona alkaloids on enantiodifferentiation , 2003 .

[59]  O. Mitsunobu The Use of Diethyl Azodicarboxylate and Triphenylphosphine in Synthesis and Transformation of Natural Products , 1981 .