Extraosseous plasmacytoma with an aggressive course occurring solely in the CNS

Extraosseous (extramedullary) plasmacytoma is a relatively indolent neoplasm that constitutes 3–5% of all plasma cell neoplasms. Rare cases have been reported to truly occur in the CNS and not as an extension from a nasal lesion. EBV expression in plasma cell neoplasms has been reported in very few cases that are mainly post‐transplant or occurring in severely immunosuppressed patients. We report a case of extraosseous plasmacytoma with an aggressive course in an HIV‐positive individual that occurred solely in the CNS, showing EBV expression by in situ hybridization, and presenting as an intraparenchymal mass as well as in the CSF.

[1]  M. Keramati,et al.  The association of Epstein-Barr virus infection with multiple myeloma. , 2011, Indian journal of pathology & microbiology.

[2]  D. Biesma,et al.  Central nervous system myelomatosis: review of the literature , 2007, European journal of haematology.

[3]  Sheng-Tsung Chang,et al.  Plasmablastic cytomorphologic features in plasma cell neoplasms in immunocompetent patients are significantly associated with EBV. , 2007, American journal of clinical pathology.

[4]  Hong Chang,et al.  Multiple myeloma involving central nervous system: high frequency of chromosome 17p13.1 (p53) deletions , 2004, British journal of haematology.

[5]  R. Ambinder.  Epstein-Barr virus-associated lymphoproliferative disorders. , 2003, Reviews in clinical and experimental hematology.

[6]  L. Hutt-Fletcher,et al.  A Positive Autoregulatory Loop of LMP1 Expression and STAT Activation in Epithelial Cells Latently Infected with Epstein-Barr Virus , 2003, Journal of Virology.

[7]  B. Barlogie,et al.  Myeloma of the central nervous system: association with high‐risk chromosomal abnormalities, plasmablastic morphology and extramedullary manifestations , 2002, British journal of haematology.

[8]  R. Fanin,et al.  Meningeal and cerebral involvement in multiple myeloma patients , 2001, Annals of Hematology.

[9]  M. Beksac,et al.  Frequent demonstration of human herpesvirus 8 (HHV-8) in bone marrow biopsy samples from Turkish patients with multiple myeloma (MM) , 2001, Leukemia.

[10]  N. Güler.  Extramedullary plasmacytoma: tumor occurrence and therapeutic concepts. , 2000, Cancer.

[11]  A. Crispo,et al.  Hepatitis C virus infection and new association with extrahepatic disease: multiple myeloma. , 2000, Haematologica.

[12]  J. Goedert,et al.  Spectrum of AIDS-associated malignant disorders , 1998, The Lancet.

[13]  L. Cavanna,et al.  Meningeal involvement in multiple myeloma: report of a case with cytologic and immunocytochemical diagnosis. , 1996, Acta cytologica.

[14]  I. Prieto,et al.  Plasma cell myeloma presented as myelomatous meningitis , 1994, European journal of haematology.

[15]  S. Youssefzadeh,et al.  Plasmozytom der Nase und der Nasennebenhöhlen mit intrakranieller und orbitaler Ausdehnung , 1993 .

[16]  M. Susani,et al.  [Plasmacytoma of the nose and paranasal sinuses with intracranial and orbital extension]. , 1993, Laryngo- rhino- otologie.

[17]  J. Gold,et al.  Malignant plasma cell tumors in human immunodeficiency virus‐infected patients , 1990, Cancer.

[18]  R. Alexanian.  Plasma cell neoplasms , 1978, CA: a cancer journal for clinicians.