Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and crystal structure of the Y48H mutant enzyme.
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G. Petsko | D. Ringe | D. Harrison | C. Lai | K. Bohren | K. Gabbay | C. Grimshaw | Dagmar Ringe | C. Lai | David H. T. Harrison