A dietary isothiocyanate-enriched moringa (Moringa oleifera) seed extract improves glucose tolerance in a high-fat-diet mouse model and modulates the gut microbiome.

[1]  Brittany L. Graf,et al.  Biochemical characterization and anti-inflammatory properties of an isothiocyanate-enriched moringa (Moringa oleifera) seed extract , 2017, PloS one.

[2]  O. Oguntibeju,et al.  Assessment of the Anti-Hyperglycaemic, Anti-Inflammatory and Antioxidant Activities of the Methanol Extract of Moringa Oleifera in Diabetes-Induced Nephrotoxic Male Wistar Rats , 2017, Molecules.

[3]  A. Carrier Metabolic Syndrome and Oxidative Stress: A Complex Relationship. , 2017, Antioxidants & redox signaling.

[4]  T. R. Licht,et al.  Environmental spread of microbes impacts the development of metabolic phenotypes in mice transplanted with microbial communities from humans , 2016, The ISME Journal.

[5]  M. Tuorkey Effects of Moringa oleifera aqueous leaf extract in alloxan induced diabetic mice. , 2016, Interventional medicine & applied science.

[6]  E. Mazzon,et al.  Anti-inflammatory and antioxidant effects of a combination of cannabidiol and moringin in LPS-stimulated macrophages. , 2016, Fitoterapia.

[7]  C. Sanderson,et al.  Dissecting molecular cross-talk between Nrf2 and NF-κB response pathways , 2015, Biochemical Society transactions.

[8]  I. Raskin,et al.  Isothiocyanate-rich Moringa oleifera extract reduces weight gain, insulin resistance, and hepatic gluconeogenesis in mice. , 2015, Molecular nutrition & food research.

[9]  A. Spada,et al.  Cultivation, Genetic, Ethnopharmacology, Phytochemistry and Pharmacology of Moringa oleifera Leaves: An Overview , 2015, International journal of molecular sciences.

[10]  I. Raskin,et al.  Direct and indirect antioxidant activity of polyphenol- and isothiocyanate-enriched fractions from Moringa oleifera. , 2015, Journal of agricultural and food chemistry.

[11]  A. Al-Malki,et al.  The Antidiabetic Effect of Low Doses of Moringa oleifera Lam. Seeds on Streptozotocin Induced Diabetes and Diabetic Nephropathy in Male Rats , 2015, BioMed research international.

[12]  I. Raskin,et al.  Stable, water extractable isothiocyanates from Moringa oleifera leaves attenuate inflammation in vitro. , 2014, Phytochemistry.

[13]  Lawrence A. David,et al.  Diet rapidly and reproducibly alters the human gut microbiome , 2013, Nature.

[14]  J. Hwang,et al.  Synergistic antimicrobial efficacy of mesoporous ZnO loaded with 4-(α-L-rhamnosyloxy)-benzyl isothiocyanate isolated from the Moringa oleifera seed. , 2014 .

[15]  M. Ajibola,et al.  Effects of Aqueous Extract of Moringa ole ifera Seeds on Alloxan Induced Hyperglycemia , 2014 .

[16]  Se Rim Jeon,et al.  Synergistic antimicrobial efficacy of mesoporous ZnO loaded with 4-(α-L-rhamnosyloxy)-benzyl isothiocyanate isolated from the Moringa oleifera seed. , 2014, The Journal of general and applied microbiology.

[17]  E. Mazzon,et al.  Antibacterial Activity of Glucomoringin Bioactivated with Myrosinase against Two Important Pathogens Affecting the Health of Long-Term Patients in Hospitals , 2013, Molecules.

[18]  Robert C. Edgar,et al.  UPARSE: highly accurate OTU sequences from microbial amplicon reads , 2013, Nature Methods.

[19]  Liping Zhao The gut microbiota and obesity: from correlation to causality , 2013, Nature Reviews Microbiology.

[20]  Sarah L. Westcott,et al.  Development of a Dual-Index Sequencing Strategy and Curation Pipeline for Analyzing Amplicon Sequence Data on the MiSeq Illumina Sequencing Platform , 2013, Applied and Environmental Microbiology.

[21]  D. Chartoumpekis,et al.  Send Orders of Reprints at Reprints@benthamscience.net New Player on an Old Field; the Keap1/nrf2 Pathway as a Target for Treatment of Type 2 Diabetes and Metabolic Syndrome , 2022 .

[22]  Chien-Chang Shen,et al.  Antimicrobial Isothiocyanates from the Seeds of Moringa oleifera Lam. , 2012, Zeitschrift fur Naturforschung. C, Journal of biosciences.

[23]  M. A. Saad,et al.  Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice , 2012, Diabetologia.

[24]  Patrice D Cani,et al.  Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity , 2012, Gut microbes.

[25]  M. Mbikay Therapeutic Potential of Moringa oleifera Leaves in Chronic Hyperglycemia and Dyslipidemia: A Review , 2012, Front. Pharmacol..

[26]  M. Kaneki,et al.  Liver-specific Inducible Nitric-oxide Synthase Expression Is Sufficient to Cause Hepatic Insulin Resistance and Mild Hyperglycemia in Mice* , 2011, The Journal of Biological Chemistry.

[27]  P. Lund,et al.  Role of intestinal inflammation as an early event in obesity and insulin resistance , 2011, Current opinion in clinical nutrition and metabolic care.

[28]  Patrice D Cani,et al.  The gut microbiome as therapeutic target. , 2011, Pharmacology & therapeutics.

[29]  S. Mukhopadhyay,et al.  The evil axis of obesity, inflammation and type-2 diabetes. , 2011, Endocrine, metabolic & immune disorders drug targets.

[30]  F. Crea,et al.  Profiling selected phytochemicals and nutrients in different tissues of the multipurpose tree Moringa oleifera L., grown in Ghana , 2010 .

[31]  I. Rahman,et al.  Nrf2-ARE stress response mechanism: A control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases , 2010, Free radical research.

[32]  J. Pezzuto,et al.  Potential anti-inflammatory phenolic glycosides from the medicinal plant Moringa oleifera fruits. , 2010, Bioorganic & medicinal chemistry.

[33]  A. Wilkins,et al.  Synthesis, biological evaluation, and structure-activity relationships of dithiolethiones as inducers of cytoprotective phase 2 enzymes. , 2010, Journal of medicinal chemistry.

[34]  William A. Walters,et al.  QIIME allows analysis of high-throughput community sequencing data , 2010, Nature Methods.

[35]  M. D’Incalci,et al.  The isothiocyanate produced from glucomoringin inhibits NF-kB and reduces myeloma growth in nude mice in vivo. , 2010, Biochemical pharmacology.

[36]  C. Glass,et al.  Macrophages, inflammation, and insulin resistance. , 2010, Annual review of physiology.

[37]  T. Lawrence The nuclear factor NF-kappaB pathway in inflammation. , 2009, Cold Spring Harbor perspectives in biology.

[38]  P. Qian,et al.  Conservative Fragments in Bacterial 16S rRNA Genes and Primer Design for 16S Ribosomal DNA Amplicons in Metagenomic Studies , 2009, PloS one.

[39]  Martin Hartmann,et al.  Introducing mothur: Open-Source, Platform-Independent, Community-Supported Software for Describing and Comparing Microbial Communities , 2009, Applied and Environmental Microbiology.

[40]  Patrice D Cani,et al.  Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding. , 2008, Pathologie-biologie.

[41]  R. Bibiloni,et al.  Changes in Gut Microbiota Control Metabolic Endotoxemia-Induced Inflammation in High-Fat Diet–Induced Obesity and Diabetes in Mice , 2008, Diabetes.

[42]  Thomas D. Schmittgen,et al.  Analyzing real-time PCR data by the comparative CT method , 2008, Nature Protocols.

[43]  Á. Ravelo,et al.  Dichloromethane as a solvent for lipid extraction and assessment of lipid classes and fatty acids from samples of different natures. , 2008, Journal of agricultural and food chemistry.

[44]  M. Membrez,et al.  Gut microbiota modulation with norfloxacin and ampicillin enhances glucose tolerance in mice , 2008, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[45]  R. Mithen,et al.  Glucosinolates, isothiocyanates and human health , 2008, Phytochemistry Reviews.

[46]  S. Nair,et al.  Structural Influence of Isothiocyanates on the Antioxidant Response Element (ARE)-Mediated Heme Oxygenase-1 (HO-1) Expression , 2008, Pharmaceutical Research.

[47]  J. Ferrières,et al.  Metabolic Endotoxemia Initiates Obesity and Insulin Resistance , 2007, Diabetes.

[48]  J. Tiedje,et al.  Naïve Bayesian Classifier for Rapid Assignment of rRNA Sequences into the New Bacterial Taxonomy , 2007, Applied and Environmental Microbiology.

[49]  Farooq Anwar,et al.  Moringa oleifera: a food plant with multiple medicinal uses , 2007, Phytotherapy research : PTR.

[50]  C. Knauf,et al.  Comment on: Cani et al. (2007) Metabolic Endotoxemia Initiates Obesity and Insulin Resistance: Diabetes , 2007 .

[51]  E. Mardis,et al.  An obesity-associated gut microbiome with increased capacity for energy harvest , 2006, Nature.

[52]  A. Kong,et al.  Gene expression profiles induced by cancer chemopreventive isothiocyanate sulforaphane in the liver of C57BL/6J mice and C57BL/6J/Nrf2 (-/-) mice. , 2006, Cancer letters.

[53]  R. Knight,et al.  UniFrac: a New Phylogenetic Method for Comparing Microbial Communities , 2005, Applied and Environmental Microbiology.

[54]  R. D'Agostino,et al.  Metabolic Syndrome as a Precursor of Cardiovascular Disease and Type 2 Diabetes Mellitus , 2005, Circulation.

[55]  K. Kunii,et al.  A role for iNOS in fasting hyperglycemia and impaired insulin signaling in the liver of obese diabetic mice. , 2005, Diabetes.

[56]  A. Dinkova-Kostova,et al.  Chemical structures of inducers of nicotinamide quinone oxidoreductase 1 (NQO1). , 2004, Methods in enzymology.

[57]  D. Cowan,et al.  Review and re-analysis of domain-specific 16S primers. , 2003, Journal of microbiological methods.

[58]  Y. Benjamini,et al.  Controlling the false discovery rate: a practical and powerful approach to multiple testing , 1995 .

[59]  U. Eilert,et al.  The Antibiotic Principle of Seeds of Moringa oleifera and Moringa stenopetala1 , 1981, Planta medica.

[60]  G. Thompson,et al.  Progress report Gastrointestinal structure and function in germ-free or gnotobiotic animals , 2006 .

[61]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.