Anthocyanin oligomer (grape skin extract) administration improves dry eye disease: A randomised, double‐blind, placebo‐controlled study

Dry eye disease is a chronic, progressive ocular disease characterised by ocular discomfort and is one of the most common ophthalmological disorders that affects people's lives.

[1]  T. Takeuchi,et al.  Autoimmune Epithelitis and Chronic Inflammation in Sjögren’s Syndrome-Related Dry Eye Disease , 2021, International journal of molecular sciences.

[2]  A. Mehmood,et al.  Dietary anthocyanins as potential natural modulators for the prevention and treatment of non-alcoholic fatty liver disease: A comprehensive review. , 2021, Food research international.

[3]  T. Richard,et al.  Polyphenolic Characterization of Merlot, Tannat and Syrah Skin Extracts at Different Degrees of Maturity and Anti-Inflammatory Potential in RAW 264.7 Cells , 2021, Foods.

[4]  Swati Singh,et al.  Tear secretion from the lacrimal gland: variations in normal versus dry eyes , 2021, British Journal of Ophthalmology.

[5]  I. Khan,et al.  Frequency and impact of individual symptoms on quality of life in dry eye disease in patients presenting to a tertiary care hospital. , 2021, JPMA. The Journal of the Pakistan Medical Association.

[6]  F. Barba,et al.  Micro and nano-encapsulation of vegetable and essential oils to develop functional food products with improved nutritional profiles , 2020 .

[7]  R. Kardon,et al.  Photophobia: shared pathophysiology underlying dry eye disease, migraine and traumatic brain injury leading to central neuroplasticity of the trigeminothalamic pathway , 2020, British Journal of Ophthalmology.

[8]  P. Teissèdre,et al.  Phenolic Compounds of Grapes and Wines: Key Compounds and Implications in Sensory Perception , 2020, Chemistry and Biochemistry of Winemaking, Wine Stabilization and Aging.

[9]  N. El-Haddad,et al.  Comparison between topical cyclosporine A 0.05% and oral antioxidant in the treatment of dry eye disease , 2020 .

[10]  Shu-Wen Chang,et al.  Normalized ocular surface temperature models for tear film characteristics and dry eye disease evaluation. , 2020, The ocular surface.

[11]  C. Belmonte Pain, Dryness, and Itch Sensations in Eye Surface Disorders Are Defined By a Balance Between Inflammation and Sensory Nerve Injury. , 2019, Cornea.

[12]  Y. Choi,et al.  In Vivo Effects of Polymerized Anthocyanin from Grape Skin on Benign Prostatic Hyperplasia , 2019, Nutrients.

[13]  I. Nagaoka,et al.  The potential use of grape phytochemicals for preventing the development of intestine-related and subsequent inflammatory diseases. , 2019, Endocrine, metabolic & immune disorders drug targets.

[14]  Hyung Bin Hwang,et al.  Effects of Grape Skin Extract, Anthocyanin Oligomer, on a Murine Dry Eye Model , 2019, Journal of the Korean Society of Food Science and Nutrition.

[15]  Preeya K Gupta,et al.  Dry Eye Disease: Consideration for Women's Health , 2019, Journal of women's health.

[16]  R. Dana,et al.  Estimated Prevalence and Incidence of Dry Eye Disease Based on Coding Analysis of a Large, All-age United States Health Care System. , 2019, American journal of ophthalmology.

[17]  J. A. Gomes,et al.  The impact of dry eye disease treatment on patient satisfaction and quality of life: A review. , 2019, The ocular surface.

[18]  K. Tsubota,et al.  Potential Role of Oxidative Stress in Ocular Surface Inflammation and Dry Eye Disease. , 2018, Investigative ophthalmology & visual science.

[19]  M. Labetoulle,et al.  Role of corneal nerves in ocular surface homeostasis and disease , 2018, Acta ophthalmologica.

[20]  Hyung Bin Hwang,et al.  Anthocyanin oligomers counteracts ischemic and oxidative insults to retinal cells and lipid peroxidation to brain membranes , 2018 .

[21]  K. Tsubota,et al.  Impact of lifestyle intervention on dry eye disease in office workers: a randomized controlled trial , 2018, Journal of occupational health.

[22]  M. Markoulli,et al.  Imaging the Tear Film: A Comparison Between the Subjective Keeler Tearscope-Plus™ and the Objective Oculus® Keratograph 5M and LipiView® Interferometer , 2018, Current eye research.

[23]  S. Kinoshita,et al.  The role of systemic and topical fatty acids for dry eye treatment , 2017, Progress in Retinal and Eye Research.

[24]  P. Thulasi,et al.  Update in Current Diagnostics and Therapeutics of Dry Eye Disease. , 2017, Ophthalmology.

[25]  Mitchell A Jackson,et al.  Dysfunctional tear syndrome: dry eye disease and associated tear film disorders – new strategies for diagnosis and treatment , 2017, Current opinion in ophthalmology.

[26]  J. Moon,et al.  Smartphone use is a risk factor for pediatric dry eye disease according to region and age: a case control study , 2016, BMC Ophthalmology.

[27]  Angelika Unterhuber,et al.  Tear Film Thickness After Treatment With Artificial Tears in Patients With Moderate Dry Eye Disease , 2015, Cornea.

[28]  E. Messmer The pathophysiology, diagnosis, and treatment of dry eye disease. , 2015, Deutsches Arzteblatt international.

[29]  C. Creuzot-Garcher,et al.  Ocular tolerability and efficacy of a cationic emulsion in patients with mild to moderate dry eye disease - a randomised comparative study. , 2014, Journal francais d'ophtalmologie.

[30]  K. Tsubota,et al.  Delphinidin 3,5-O-diglucoside, a constituent of the maqui berry (Aristotelia chilensis) anthocyanin, restores tear secretion in a rat dry eye model , 2014 .

[31]  J. Kim,et al.  Ginkgo biloba extract and bilberry anthocyanins improve visual function in patients with normal tension glaucoma. , 2012, Journal of medicinal food.

[32]  P. Park,et al.  Antioxidant activity and protective effect of anthocyanin oligomers on H₂O₂-triggered G2/M arrest in retinal cells. , 2012, Journal of agricultural and food chemistry.

[33]  N. Friedman,et al.  Impact of dry eye disease and treatment on quality of life , 2010, Current opinion in ophthalmology.

[34]  R. Schiffman,et al.  Reliability and validity of the Ocular Surface Disease Index. , 2000, Archives of ophthalmology.

[35]  J. Royer,et al.  [The dry eye]. , 1985, Klinische Monatsblatter fur Augenheilkunde.

[36]  Poonam Mudgil Evaluation of use of essential fatty acids in topical ophthalmic preparations for dry eye. , 2019, The ocular surface.

[37]  H. Ohta,et al.  Comparison of Anthocyanins, Proanthocyanidin Oligomers and Antioxidant Capacity between Cowpea and Grain Legumes with Colored Seed Coat , 2019, Food Science and Technology Research.