Ganoderma lucidum (Fr.) P. Karst occurring in South India attenuates gastric ulceration in rats

The ethanol extract of Ganoderma lucidum (Fr.) P. Karst occurring in South India was examined for antiulcer activity against ethanol and Indomethacin induced ulcer in rats. Pretreatment of oral doses of 500 mg/kg and 1000 mg/kg showed significant reduction of ulcer index, with a percentage of inhibition of 55.17, 72.79 and 47 and 76.14% in ethanol and Indomethacin induced gastric ulceration, respectively. Administration of G. lucidum extract elevated the levels of Glutathione (GSH) as well as activities of Superoxide dismutase (SOD), Glutathione Peroxidase (GPx) and Catalase (CAT) and significantly lowered the levels of lipid peroxidation (LPO) in a dose dependent manner. The antiulcer property of the mushroom might be due to its profound free radical scavenging activity. The findings suggest the potential therapeutic use of G. lucidum as an effective non-toxic antiulcer agent.

[1]  M. Babincová,et al.  Antiulcer activity of water extract of Scoparia dulcis. , 2008, Fitoterapia.

[2]  C. Nair,et al.  Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo. , 2008, Environmental toxicology and pharmacology.

[3]  R. Paterson,et al.  Ganoderma — A Therapeutic Fungal Biofactory , 2006 .

[4]  J. C. Tilak,et al.  Evaluation of Antioxidant Activity of Selected Indian Mushrooms , 2004 .

[5]  Shufeng Zhou,et al.  Cancer Prevention and Treatment by Ganoderma, a Mushroom with Medicinal Properties , 2003 .

[6]  M. Huang,et al.  Mechanism of the antiulcerogenic effect of Ganoderma lucidum polysaccharides on indomethacin-induced lesions in the rat. , 2002, Life sciences.

[7]  D. Bandyopadhyay,et al.  Involvement of reactive oxygen species in gastric ulceration: protection by melatonin. , 2002, Indian journal of experimental biology.

[8]  M. Repetto,et al.  Antioxidant properties of natural compounds used in popular medicine for gastric ulcers. , 2002, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.

[9]  J. Belaiche,et al.  Observational survey of NSAID-related upper gastro-intestinal adverse events in Belgium. , 2002, Acta gastro-enterologica Belgica.

[10]  F. Borrelli,et al.  The plant kingdom as a source of anti‐ulcer remedies , 2000, Phytotherapy research : PTR.

[11]  E. Silveira,et al.  Gastroprotective effect of Copaifera langsdorffii oleo-resin on experimental gastric ulcer models in rats. , 1998, Journal of ethnopharmacology.

[12]  I. Bjarnason,et al.  NSAIDs, Cox-2 inhibitors, and the gut , 1995, The Lancet.

[13]  J. Wallace,et al.  Role of oxygen-derived free radicals in indomethacin-induced gastric injury. , 1991, The American journal of physiology.

[14]  S. Szabó,et al.  Free radicals and lipid peroxidation in ethanol- or aspirin-induced gastric mucosal injury , 1987, Digestive Diseases and Sciences.

[15]  R. Goel,et al.  A modified method to estimate dissolved mucosubstances in gastric juice. , 1983, Indian journal of experimental biology.

[16]  B. Mannervik,et al.  Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. , 1979, Biochimica et biophysica acta.

[17]  B. Whittle,et al.  INVESTIGATION OF THE VASODILATOR AND ANTISECRETORY ROLE OF PROSTAGLANDINS IN THE RAT GASTRIC MUCOSA BY USE OF NON‐STEROIDAL ANTI‐INFLAMMATORY DRUGS , 1975, British journal of pharmacology.

[18]  D. Hafeman,et al.  Effect of dietary selenium on erythrocyte and liver glutathione peroxidase in the rat. , 1974, The Journal of nutrition.

[19]  I. Fridovich,et al.  Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein). , 1969, The Journal of biological chemistry.

[20]  Oliver H. Lowry,et al.  Protein measurement with the Folin phenol reagent. , 1951, The Journal of biological chemistry.

[21]  K. Janardhanan,et al.  Prevention of nephrotoxicity induced by the anticancer drug cisplatin, using Ganoderma lucidum, a medicinal mushroom occurring in South India , 2003 .

[22]  K. Janardhanan,et al.  Antioxidant and Antitumor Activity of Ganoderma lucidum (Curt.: Fr.) P. Karst.Reishi (Aphyllophoromycetideae) from South India , 2000 .

[23]  S C Jong,et al.  Medicinal benefits of the mushroom Ganoderma. , 1992, Advances in applied microbiology.

[24]  P. Oates,et al.  Studies on the mechanism of ethanol-induced gastric damage in rats. , 1988, Gastroenterology.

[25]  大川 博,et al.  Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction , 1979 .