Pharmacological evidence for two kinds of GABA receptors on rat hippocampal pyramidal cells studied in vitro

1. The rat hippocampal slice preparation has been used in conjunction with intracellular recording and ionophoresis to study the action of γ‐aminobutyric acid (GABA) on CA1 pyramidal cells.

[1]  J. Eccles,et al.  PATHWAY OF POSTSYNAPTIC INHIBITION IN THE HIPPOCAMPUS. , 1964, Journal of neurophysiology.

[2]  M. Neal,et al.  THE UPTAKE OF [3H]GABA BY SLICES OF RAT CEREBRAL CORTEX , 1968, Journal of neurochemistry.

[3]  L. Iversen,et al.  GABA UPTAKE IN RAT CENTRAL NERVOUS SYSTEM: COMPARISON OF UPTAKE IN SLICES AND HOMOGENATES AND THE EFFECTS OF SOME INHIBITORS , 1971, Journal of neurochemistry.

[4]  L. T. Graham,et al.  A simple preparation of bicuculline methiodide, a water-soluble GABA antagonist. , 1973, Brain research.

[5]  D. Brown,et al.  DEPOLARIZING ACTIONS OF γ‐AMINOBUTYRIC ACID AND RELATED COMPOUNDS ON RAT SUPERIOR CERVICAL GANGLIA IN VITRO , 1974, British journal of pharmacology.

[6]  D. A. Brown,et al.  Actions of gamma‐aminobutyric acid on sympathetic ganglion cells. , 1975, The Journal of physiology.

[7]  P. Krogsgaard‐Larsen,et al.  INHIBITION OF GABA UPTAKE IN RAT BRAIN SLICES BY NIPECOTIC ACID, VARIOUS ISOXAZOLES AND RELATED COMPOUNDS , 1975, Journal of neurochemistry.

[8]  R. Nicoll,et al.  Analysis of amino acid responses on frog motoneurones , 1976, Neuropharmacology.

[9]  J. Barker,et al.  Pentobarbital selectively enhances GABA-mediated post-synaptic inhibition in tissue cultured mouse spinal neurons , 1976, Brain Research.

[10]  Some Properties of Synapses near to and far from the Soma of Hippocampal Pyramids , 1976 .

[11]  K. Obata,et al.  Excitatory and inhibitory actions of GABA and glycine on embryonic chick spinal neurons in culture , 1978, Brain Research.

[12]  H. Higashi,et al.  Characterization and ionic basis of GABA‐induced depolarizations recorded in vitro from cat primary afferent neurones. , 1978, The Journal of physiology.

[13]  P. Krogsgaard‐Larsen,et al.  STRUCTURE‐ACTIVITY STUDIES ON THE INHIBITION OF GABA BINDING TO RAT BRAIN MEMBRANES BY MUSCIMOL AND RELATED COMPOUNDS , 1978, Journal of neurochemistry.

[14]  J. Barker,et al.  Amino acid pharmacology of mammalian central neurones grown in tissue culture. , 1978, The Journal of physiology.

[15]  J. E. Vaughn,et al.  Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport , 1978, Brain Research.

[16]  R. Nicoll,et al.  GABA-mediated biphasic inhibitory responses in hippocampus , 1979, Nature.

[17]  C. Scholfield,et al.  DEPOLARIZATION OF NEURONES IN THE ISOLATED OLFACTORY CORTEX OF THE GUINEA‐PIG BY γ‐AMINOBUTYRIC ACID , 1979, British journal of pharmacology.

[18]  D. A. Brown Extrasynaptic GABA systems , 1979, Trends in Neurosciences.

[19]  A conductance decrease after application of GABA to crayfish muscle fibers. , 1979, Journal de physiologie.

[20]  D. Gruol,et al.  Hydrogen ions have multiple effects on the excitability of cultured mammalian neurons , 1980, Brain Research.

[21]  R. H. Evans,et al.  γ‐AMINOBUTYRIC ACID AGONISTS: AN in vitro COMPARISON BETWEEN DEPRESSION OF SPINAL SYNAPTIC ACTIVITY AND DEPOLARIZATION OF SPINAL ROOT FIBRES IN THE RAT , 1980, British journal of pharmacology.

[22]  R. Dingledine,et al.  Reduced inhibition during epileptiform activity in the in vitro hippocampal slice. , 1980, The Journal of physiology.

[23]  P. Andersen,et al.  Two different responses of hippocampal pyramidal cells to application of gamma‐amino butyric acid. , 1980, The Journal of physiology.

[24]  G. Fischbach,et al.  GABA conductance of chick spinal cord and dorsal root ganglion neurons in cell culture. , 1981, Journal of neurophysiology.

[25]  V. Crunelli,et al.  Depolarizing postsynaptic actions of GABA in the rat dentate gyrus. , 1981, Advances in biochemical psychopharmacology.

[26]  R. Thalmann,et al.  Biphasic response of hippocampal pyramidal neurons to GABA , 1981, Neuroscience Letters.

[27]  H. Jahnsen,et al.  The effects of a benzodiazepine on the hyperpolarizing and the depolarizing responses of hippocampal cells to GABA , 1981, Brain Research.

[28]  R. Olsen,et al.  Convulsant and anticonvulsant drug binding sites related to GABA-regulated chloride ion channels. , 1981, Advances in biochemical psychopharmacology.

[29]  D. A. Brown,et al.  Actions of GABA on mammalian neurones, axons, and nerve terminals. , 1981, Advances in biochemical psychopharmacology.

[30]  R. Nicoll,et al.  Feed‐forward dendritic inhibition in rat hippocampal pyramidal cells studied in vitro , 1982, The Journal of physiology.