Biological and Clinical Implications of Early-Onset Cancers: A Unique Subtype.

[1]  T. Rebbeck,et al.  Is early-onset cancer an emerging global epidemic? Current evidence and future implications , 2022, Nature Reviews Clinical Oncology.

[2]  Hongda Liu,et al.  Multi‑institutional development and validation of a nomogram to predict prognosis of early-onset gastric cancer patients , 2022, Frontiers in Immunology.

[3]  Richard S. Kwon,et al.  Ethnic disparities in early-onset gastric cancer: a population-based study in Texas and California. , 2022, Cancer Epidemiology, Biomarkers and Prevention.

[4]  O. Alese,et al.  Early-onset pancreatic cancer: a review of molecular mechanisms, management, and survival , 2022, Oncotarget.

[5]  Richard S. Kwon,et al.  The Multicenter Cancer of Pancreas Screening Study: Impact on Stage and Survival , 2022, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[6]  F. Sinicrope.  Increasing Incidence of Early-Onset Colorectal Cancer. , 2022, The New England journal of medicine.

[7]  M. McCullough,et al.  The age-dependent association of risk factors with pancreatic cancer. , 2022, Annals of oncology : official journal of the European Society for Medical Oncology.

[8]  N. Sasahira,et al.  Early-onset pancreatic cancer: Clinical characteristics and survival outcomes. , 2022, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[9]  M. Hou,et al.  Association of early-onset breast cancer with body mass index, menarche, and menopause in Taiwan , 2022, BMC cancer.

[10]  K. Offit,et al.  Early age of onset and broad cancer spectrum persist in MSH6- and PMS2-associated Lynch syndrome. , 2022, Genetics in medicine : official journal of the American College of Medical Genetics.

[11]  N. Sasahira,et al.  Molecular Features and Clinical Management of Hereditary Pancreatic Cancer Syndromes and Familial Pancreatic Cancer , 2022, International journal of molecular sciences.

[12]  A. Jemal,et al.  Cancer statistics, 2022 , 2022, CA: a cancer journal for clinicians.

[13]  J. Ludvigsson,et al.  Antibiotic Therapy and Risk of Early-Onset Colorectal Cancer: A National Case-Control Study , 2022, Clinical and translational gastroenterology.

[14]  C. Eng,et al.  A comprehensive framework for early-onset colorectal cancer research. , 2022, The Lancet. Oncology.

[15]  Swati G. Patel,et al.  The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection. , 2022, The lancet. Gastroenterology & hepatology.

[16]  K. Pantel,et al.  Current and Future Clinical Applications of ctDNA in Immuno-Oncology , 2021, Cancer Research.

[17]  A. Lenis,et al.  Germline Variants Identified in Patients with Early-onset Renal Cell Carcinoma Referred for Germline Genetic Testing. , 2021, European urology oncology.

[18]  A. Gavin,et al.  The European cancer burden in 2020: Incidence and mortality estimates for 40 countries and 25 major cancers , 2021, European journal of cancer.

[19]  A. Biankin,et al.  Genomic and Molecular Analyses Identify Molecular Subtypes of Pancreatic Cancer Recurrence , 2021, Gastroenterology.

[20]  Jinbo Chen,et al.  Relationship of established risk factors with breast cancer subtypes , 2021, Cancer medicine.

[21]  Ming Liu,et al.  A Distinct Clinicopathological Feature and Prognosis of Young Gastric Cancer Patients Aged ≤ 45 Years Old , 2021, Frontiers in Oncology.

[22]  B. Taylor,et al.  A Comprehensive Comparison of Early-Onset and Average-Onset Colorectal Cancers. , 2021, Journal of the National Cancer Institute.

[23]  M. Gonen,et al.  Treatment patterns and survival in patients with early‐onset pancreatic cancer , 2021, Cancer.

[24]  P. Philip,et al.  BRCA mutations in pancreatic cancer and progress in their targeting , 2021, Expert opinion on therapeutic targets.

[25]  Swati G. Patel,et al.  Characteristics of Early-Onset vs Late-Onset Colorectal Cancer: A Review. , 2021, JAMA surgery.

[26]  L. Moreira,et al.  Clinical, Molecular and Genetic Characteristics of Early Onset Gastric Cancer: Analysis of a Large Multicenter Study , 2021, Cancers.

[27]  Dan J Stein,et al.  Spatial, temporal, and demographic patterns in prevalence of smoking tobacco use and attributable disease burden in 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019 , 2021, Lancet.

[28]  Aung Ko Win,et al.  Nongenetic Determinants of Risk for Early-Onset Colorectal Cancer , 2021, JNCI cancer spectrum.

[29]  F. Vleggaar,et al.  Long-term yield of pancreatic cancer surveillance in high-risk individuals , 2021, Gut.

[30]  E. Nakakura,et al.  Pancreatic Adenocarcinoma, Version 2.2021, NCCN Clinical Practice Guidelines in Oncology. , 2021, Journal of the National Comprehensive Cancer Network : JNCCN.

[31]  S. Sulong,et al.  The Unique Biology behind the Early Onset of Breast Cancer , 2021, Genes.

[32]  J. Hou,et al.  Coupled liquid biopsy and bioinformatics for pancreatic cancer early detection and precision prognostication , 2021, Molecular Cancer.

[33]  A. Jemal,et al.  Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries , 2021, CA: a cancer journal for clinicians.

[34]  J. Lozano,et al.  Identification of New Genes Involved in Germline Predisposition to Early-Onset Gastric Cancer , 2021, International journal of molecular sciences.

[35]  G. Frampton,et al.  Early-onset metastatic and clinically advanced prostate cancer is a distinct clinical and molecular entity characterized by increased TMPRSS2–ERG fusions , 2021, Prostate Cancer and Prostatic Diseases.

[36]  Jeffrey-K Lee,et al.  An update on the epidemiology, molecular characterization, diagnosis, and screening strategies for early-onset colorectal cancer. , 2021, Gastroenterology.

[37]  Mei Xu,et al.  Development and validation of a SEER-based prognostic nomogram for cervical cancer patients below the age of 45 years , 2020, Bosnian journal of basic medical sciences.

[38]  M. Barakat,et al.  Early- and late-onset pancreatic adenocarcinoma: A population-based comparative study. , 2020, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[39]  A. Bleyer,et al.  Trends in Cancer Incidence in US Adolescents and Young Adults, 1973-2015 , 2020, JAMA network open.

[40]  H. Min,et al.  Gender Convergence in Alcohol Consumption Patterns: Findings from the Korea National Health and Nutrition Examination Survey 2007–2016 , 2020, International journal of environmental research and public health.

[41]  S. Ogino,et al.  Rising incidence of early-onset colorectal cancer — a call to action , 2020, Nature Reviews Clinical Oncology.

[42]  W. Willett,et al.  Comprehensive Assessment of Diet Quality and Risk of Precursors of Early-Onset Colorectal Cancer. , 2020, Journal of the National Cancer Institute.

[43]  R. Hayes,et al.  Risk Factors Associated With Early-onset Colorectal Cancer. , 2020, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[44]  S. Shroff,et al.  Morphologic and molecular analysis of early‐onset gastric cancer , 2020, Cancer.

[45]  Xianjun Yu,et al.  Molecular alterations and targeted therapy in pancreatic ductal adenocarcinoma , 2020, Journal of Hematology & Oncology.

[46]  G. Millet,et al.  Exercise and colorectal cancer: a systematic review and meta-analysis of exercise safety, feasibility and effectiveness , 2020, International Journal of Behavioral Nutrition and Physical Activity.

[47]  A. Jemal,et al.  Cancer statistics for adolescents and young adults, 2020 , 2020, CA: a cancer journal for clinicians.

[48]  C. Murphy,et al.  Early onset esophageal adenocarcinoma presents with advanced stage disease but has improved survival compared with older individuals. , 2020, Gastroenterology.

[49]  J. Ferlay,et al.  Estimated global cancer incidence in the oldest adults in 2018 and projections to 2050 , 2020, International journal of cancer.

[50]  M. Pearlman,et al.  Executive Summary of the Early-Onset Breast Cancer Evidence Review Conference , 2020, Obstetrics and gynecology.

[51]  Wanqing Chen,et al.  Cancer burden of major cancers in China: A need for sustainable actions , 2020, Cancer communications.

[52]  Edward L. Giovannucci,et al.  Global Burden of 5 Major Types Of Gastrointestinal Cancer. , 2020, Gastroenterology.

[53]  C. Eng,et al.  Investigating the Link between Lynch Syndrome and Breast Cancer. , 2020, European journal of breast health.

[54]  A. Ui,et al.  Relationship among DNA double‐strand break (DSB), DSB repair, and transcription prevents genome instability and cancer , 2020, Cancer science.

[55]  H. Eguchi,et al.  Characteristics of early‐onset pancreatic cancer and its association with familial pancreatic cancer and hereditary pancreatic cancer syndromes , 2020, Annals of gastroenterological surgery.

[56]  Swati G. Patel,et al.  Aggressive case of early onset gastric cancer; identifying the knowledge gap , 2020, Gut.

[57]  Jian Li.  Gastric Cancer in Young Adults: A Different Clinical Entity from Carcinogenesis to Prognosis , 2020, Gastroenterology research and practice.

[58]  F. Fu,et al.  The spectrum of BRCA1 and BRCA2 mutations and clinicopathological characteristics in Chinese women with early-onset breast cancer , 2020, Breast Cancer Research and Treatment.

[59]  E. Low,et al.  Risk Factors for Early-Onset Colorectal Cancer. , 2020, Gastroenterology.

[60]  E. Stoffel,et al.  Epidemiology and Mechanisms of the Increasing Incidence of Colon and Rectal Cancers in Young Adults. , 2020, Gastroenterology.

[61]  N. Schork,et al.  Circulating tumor DNA as an early cancer detection tool. , 2019, Pharmacology & therapeutics.

[62]  S. Thakkar,et al.  Old vs new: Risk factors predicting early onset colorectal cancer , 2019, World journal of gastrointestinal oncology.

[63]  Yujie Zhang,et al.  Development and validation of prognostic nomogram for young patients with gastric cancer. , 2019, Annals of translational medicine.

[64]  D. Cunningham,et al.  Outcomes of Patients with Early Onset Colorectal Cancer Treated in a UK Specialist Cancer Center , 2019, Cancers.

[65]  H. van Attikum,et al.  PARP Inhibitor Resistance: A Tug-of-War in BRCA-Mutated Cells. , 2019, Trends in cell biology.

[66]  A. McTiernan,et al.  World Cancer Research Fund International: Continuous Update Project—systematic literature review and meta-analysis of observational cohort studies on physical activity, sedentary behavior, adiposity, and weight change and breast cancer risk , 2019, Cancer Causes & Control.

[67]  A. Zaniboni,et al.  Use of Antibiotics and Risk of Cancer: A Systematic Review and Meta-Analysis of Observational Studies , 2019, Cancers.

[68]  R. Andersson,et al.  Early-onset pancreatic cancer: a population-based study using the SEER registry , 2019, Langenbeck's Archives of Surgery.

[69]  M. Kendrick,et al.  Early-onset gastric cancer is a distinct disease with worrisome trends and oncogenic features. , 2019, Surgery.

[70]  E. Giovannucci,et al.  Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies , 2019, Nature Reviews Gastroenterology & Hepatology.

[71]  Zhuo Wang,et al.  The prognostic impact of age in different molecular subtypes of breast cancer: a population-based study , 2019, PeerJ.

[72]  Joon-Oh Park,et al.  Maintenance Olaparib for Germline BRCA-Mutated Metastatic Pancreatic Cancer. , 2019, The New England journal of medicine.

[73]  V. Moreno,et al.  Low adherence to the western and high adherence to the mediterranean dietary patterns could prevent colorectal cancer , 2019, European Journal of Nutrition.

[74]  S. Stättner,et al.  Pancreatic cancer in young adults: changes, challenges, and solutions , 2019, OncoTargets and therapy.

[75]  R. Hruban,et al.  Deleterious Germline Mutations Are a Risk Factor for Neoplastic Progression Among High-Risk Individuals Undergoing Pancreatic Surveillance. , 2019, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[76]  Q. Hu,et al.  Early‐onset triple‐negative breast cancer in multiracial/ethnic populations: Distinct trends of prevalence of truncation mutations , 2019, Cancer medicine.

[77]  Chien-Jen Chen,et al.  Tobacco Smoking and Mortality in Asia , 2019, JAMA network open.

[78]  D. Park,et al.  Proteogenomic Characterization of Human Early-Onset Gastric Cancer. , 2019, Cancer cell.

[79]  S. Leach,et al.  Genomic Landscape of Pancreatic Adenocarcinoma in Younger versus Older Patients: Does Age Matter? , 2019, Clinical Cancer Research.

[80]  A. Bardelli,et al.  Early‐onset colorectal cancer in young individuals , 2018, Molecular oncology.

[81]  K. Brennan,et al.  Disease Characteristics, Clinical Management, and Outcomes of Young Patients With Colon Cancer: A Population‐based Study , 2018, Clinical colorectal cancer.

[82]  Takafumi N. Yamaguchi,et al.  Molecular Evolution of Early-Onset Prostate Cancer Identifies Molecular Risk Markers and Clinical Trajectories. , 2018, Cancer cell.

[83]  W. Willett,et al.  Sedentary Behaviors, TV Viewing Time, and Risk of Young-Onset Colorectal Cancer , 2018, JNCI cancer spectrum.

[84]  W. Willett,et al.  Cancer prevention: Molecular and epidemiologic consensus , 2018, Science.

[85]  E. Dutson,et al.  Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California , 2018, Journal of obesity.

[86]  R. Feakins,et al.  Demographic, clinical, and pathological features of early onset pancreatic cancer patients , 2018, BMC Gastroenterology.

[87]  J. Kristek,et al.  BREAST CANCER IN YOUNG WOMEN: PATHOLOGIC AND IMMUNOHISTOCHEMICAL FEATURES , 2018, Acta clinica Croatica.

[88]  T. Hothorn,et al.  Impact of age on the efficacy of oxaliplatin in the preoperative chemoradiotherapy and adjuvant chemotherapy of rectal cancer: a post hoc analysis of the CAO/ARO/AIO-04 phase III trial , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

[89]  A. Lophatananon,et al.  Risk of breast cancer in the UK biobank female cohort and its relationship to anthropometric and reproductive factors , 2018, PloS one.

[90]  C. Allegra,et al.  Rectal cancer patients younger than 50 years lack a survival benefit from NCCN guideline–directed treatment for stage II and III disease , 2018, Cancer.

[91]  M. Hudson,et al.  Reproductive Function and Outcomes in Female Survivors of Childhood, Adolescent, and Young Adult Cancer: A Review. , 2018, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[92]  D. Stark,et al.  The management of adolescents and young adults with cancer. , 2018, Cancer treatment reviews.

[93]  H. Oweira,et al.  Exploring the differences between early-onset gastric cancer and traditional-onset gastric cancer. , 2018, Journal of gastrointestinal oncology.

[94]  Y. Kanemitsu,et al.  Shorter survival in adolescent and young adult patients, compared to adult patients, with stage IV colorectal cancer in Japan , 2018, BMC Cancer.

[95]  David Evans,et al.  Germline BRCA mutation and outcome in young-onset breast cancer (POSH): a prospective cohort study , 2018, The Lancet. Oncology.

[96]  J. Ferlay,et al.  Cancer incidence and mortality among young adults aged 20-39 years worldwide in 2012: a population-based study. , 2017, The Lancet. Oncology.

[97]  P. Sparén,et al.  Risk of early-onset prostate cancer associated with occupation in the Nordic countries. , 2017, European journal of cancer.

[98]  S. Rais-Bahrami,et al.  Pathologic and clinical characteristics of early onset renal cell carcinoma. , 2017, Human pathology.

[99]  J. Church,et al.  Colorectal surveillance after segmental resection for young‐onset colorectal cancer: is there evidence for extended resection? , 2017, Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland.

[100]  Gretchen A. Stevens,et al.  Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults , 2017, Lancet.

[101]  Jin‐Young Jang,et al.  Clinicopathologic and survival differences in younger patients with pancreatic ductal adenocarcinoma-A propensity score-matched comparative analysis. , 2017, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[102]  J. Korbel,et al.  Genomes of early onset prostate cancer , 2017, Current opinion in urology.

[103]  S. Ng,et al.  Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis. , 2017, Gastroenterology.

[104]  S. Zhang,et al.  Association of HLA-DRB1, HLA-DQB1 Polymorphisms with HPV 16 E6 Variants among Young Cervical Cancer Patients in China , 2017, Journal of Cancer.

[105]  P. Philip,et al.  Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors. , 2018, The oncologist.

[106]  Andrew J. Dunford,et al.  Sporadic Early-Onset Diffuse Gastric Cancers Have High Frequency of Somatic CDH1 Alterations, but Low Frequency of Somatic RHOA Mutations Compared With Late-Onset Cancers , 2017, Gastroenterology.

[107]  U. Ladabaum,et al.  Advanced‐Stage Colorectal Cancer in Persons Younger Than 50 Years Not Associated With Longer Duration of Symptoms or Time to Diagnosis , 2017, Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association.

[108]  J. Cicenas,et al.  KRAS, TP53, CDKN2A, SMAD4, BRCA1, and BRCA2 Mutations in Pancreatic Cancer , 2017, Cancers.

[109]  P. Goodfellow,et al.  Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer , 2017, JAMA oncology.

[110]  Hajime Uno,et al.  Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[111]  N. Copeland,et al.  KRAS-related proteins in pancreatic cancer. , 2016, Pharmacology & therapeutics.

[112]  A. Parikh,et al.  Early onset pancreatic malignancies: Clinical characteristics and survival associations , 2016, International journal of cancer.

[113]  Z. Zeng,et al.  Colorectal cancer in the very young: a comparative study of tumor markers, pathology and survival in early onset and adult onset patients. , 2016, Journal of pediatric surgery.

[114]  T. Fujii,et al.  Clinicopathological Characteristics of Young Patients With Pancreatic Cancer: An Analysis of Data From Pancreatic Cancer Registry of Japan Pancreas Society , 2016, Pancreas.

[115]  Ta-Chiang Liu,et al.  High frequency of KRAS mutation in early onset colorectal adenocarcinoma: implications for pathogenesis. , 2016, Human pathology.

[116]  S. Bhatia,et al.  Cardiovascular Disease Risk Profiles in Survivors of Adolescent and Young Adult (AYA) Cancer: The Kaiser Permanente AYA Cancer Survivors Study. , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[117]  A. Bilchik,et al.  Patterns and outcomes of colorectal cancer in adolescents and young adults. , 2016, The Journal of surgical research.

[118]  H. Ashktorab,et al.  Colorectal Cancer in Young African Americans: Is It Time to Revisit Guidelines and Prevention? , 2016, Digestive Diseases and Sciences.

[119]  A. Bleyer,et al.  Cancer in Adolescents and Young Adults: A Narrative Review of the Current Status and a View of the Future. , 2016, JAMA pediatrics.

[120]  L. Loeb,et al.  Human Cancers Express a Mutator Phenotype: Hypothesis, Origin, and Consequences. , 2016, Cancer research.

[121]  J. Y. Kim,et al.  Different risk factors for advanced colorectal neoplasm in young adults. , 2016, World journal of gastroenterology.

[122]  C. Anders,et al.  Biologic and clinical characteristics of adolescent and young adult cancers: Acute lymphoblastic leukemia, colorectal cancer, breast cancer, melanoma, and sarcoma , 2016, Cancer.

[123]  S. Hendren,et al.  Colorectal cancer outcomes and treatment patterns in patients too young for average‐risk screening , 2016, Cancer.

[124]  R. Maciejewski,et al.  Molecular alterations in gastric cancer with special reference to the early-onset subtype. , 2016, World journal of gastroenterology.

[125]  W. Dinjens,et al.  Early onset esophageal adenocarcinoma: a distinct molecular entity? , 2016, Oncoscience.

[126]  C. Hawkes,et al.  Sweetening of the global diet, particularly beverages: patterns, trends, and policy responses. , 2016, The lancet. Diabetes & endocrinology.

[127]  W. Bamlet,et al.  Risk Factors for Early-Onset and Very-Early-Onset Pancreatic Adenocarcinoma: A Pancreatic Cancer Case-Control Consortium (PanC4) Analysis , 2016, Pancreas.

[128]  Ahmedin Jemal,et al.  Global Cancer Incidence and Mortality Rates and Trends—An Update , 2015, Cancer Epidemiology, Biomarkers & Prevention.

[129]  B. Fang.  RAS signaling and anti-RAS therapy: lessons learned from genetically engineered mouse models, human cancer cells, and patient-related studies. , 2015, Acta biochimica et biophysica Sinica.

[130]  Y Nancy You,et al.  High Prevalence of Hereditary Cancer Syndromes in Adolescents and Young Adults With Colorectal Cancer. , 2015, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[131]  J. Skibber,et al.  Overtreatment of young adults with colon cancer: more intense treatments with unmatched survival gains. , 2015, JAMA surgery.

[132]  T. H. van der Kwast,et al.  Young-age prostate cancer , 2015, Journal of Clinical Pathology.

[133]  Siobhan M. Phillips,et al.  Survivors of Childhood Cancer in the United States: Prevalence and Burden of Morbidity , 2015, Cancer Epidemiology, Biomarkers & Prevention.

[134]  G. Costamagna,et al.  Early onset pancreatic cancer: risk factors, presentation and outcome. , 2015, Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.].

[135]  Hanan Gewefel,et al.  Breast cancer in adolescent and young adult women. , 2014, Clinical breast cancer.

[136]  A. Partridge,et al.  Biology of breast cancer in young women , 2014, Breast Cancer Research.

[137]  W. Willett,et al.  Premenopausal dietary fat in relation to pre- and post-menopausal breast cancer , 2014, Breast Cancer Research and Treatment.

[138]  W. Linehan,et al.  Defining early-onset kidney cancer: implications for germline and somatic mutation testing and clinical management. , 2014, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[139]  F. Weiss.  Pancreatic cancer risk in hereditary pancreatitis , 2014, Front. Physiol..

[140]  B. Person,et al.  Diagnosis of colon cancer differs in younger versus older patients despite similar complaints. , 2013, The Israel Medical Association journal : IMAJ.

[141]  C. Knibbe,et al.  Global trends in the incidence and prevalence of type 2 diabetes in children and adolescents: a systematic review and evaluation of methodological approaches , 2013, Diabetologia.

[142]  João Pedro de Magalhães,et al.  How ageing processes influence cancer , 2013, Nature Reviews Cancer.

[143]  J. Flynn,et al.  Colorectal cancer: are the "young" being overlooked? , 2013, American journal of surgery.

[144]  Aung Ko Win,et al.  Risks of primary extracolonic cancers following colorectal cancer in lynch syndrome. , 2012, Journal of the National Cancer Institute.

[145]  T. Gress,et al.  Familial pancreatic cancer—current knowledge , 2012, Nature Reviews Gastroenterology &Hepatology.

[146]  R. Pai,et al.  Clinicopathologic and molecular features of sporadic early-onset colorectal adenocarcinoma: an adenocarcinoma with frequent signet ring cell differentiation, rectal and sigmoid involvement, and adverse morphologic features , 2012, Modern Pathology.

[147]  David M. Thomas,et al.  Benefits and adverse events in younger versus older patients receiving adjuvant chemotherapy for colon cancer: findings from the Adjuvant Colon Cancer Endpoints data set. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[148]  G. Colditz,et al.  Family history and risk of breast cancer: nurses’ health study , 2012, Breast Cancer Research and Treatment.

[149]  Lodovico Balducci,et al.  Cancer and age: general considerations. , 2012, Clinics in geriatric medicine.

[150]  David M. Thomas,et al.  Impact of young age on treatment efficacy and safety in advanced colorectal cancer: a pooled analysis of patients from nine first-line phase III chemotherapy trials. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[151]  R. Barr,et al.  Adolescents, young adults, and cancer—the international challenge , 2011, Cancer.

[152]  Pierre Michel,et al.  FOLFIRINOX versus gemcitabine for metastatic pancreatic cancer. , 2011, The New England journal of medicine.

[153]  D. Christiani,et al.  Association between polymorphisms in cancer-related genes and early onset of esophageal adenocarcinoma. , 2011, Neoplasia.

[154]  P. Lähteenmäki,et al.  Physical activity and fitness in adolescent and young adult long-term survivors of childhood acute lymphoblastic leukaemia , 2010, Journal of cancer survivorship : research and practice.

[155]  G. Offerhaus,et al.  Early-onset gastric cancer: Learning lessons from the young. , 2010, World journal of gastrointestinal oncology.

[156]  S. Hankinson,et al.  Circulating Sex Steroids and Breast Cancer Risk in Premenopausal Women , 2010, Hormones & cancer.

[157]  A. Ferrari,et al.  Distinct features of colorectal cancer in children and adolescents , 2010, Cancer.

[158]  S. Gruber,et al.  Risk of pancreatic cancer in families with Lynch syndrome. , 2009, JAMA.

[159]  Pedro C Hallal,et al.  Temporal trends in physical activity: a systematic review. , 2009, Journal of physical activity & health.

[160]  R. Vierkant,et al.  Young-Onset Colorectal Cancer in Patients With No Known Genetic Predisposition: Can We Increase Early Recognition and Improve Outcome? , 2008, Medicine.

[161]  David M. Thomas,et al.  The distinctive biology of cancer in adolescents and young adults , 2008, Nature Reviews Cancer.

[162]  P. Ruszniewski,et al.  Risk of Pancreatic Adenocarcinoma in Patients With Hereditary Pancreatitis: A National Exhaustive Series , 2008, The American Journal of Gastroenterology.

[163]  P. Maisonneuve,et al.  Early Onset Pancreatic Cancer: Evidence of a Major Role for Smoking and Genetic Factors , 2007, Cancer Epidemiology Biomarkers & Prevention.

[164]  Weihong Wang,et al.  Non-steroidal anti-inflammatory drugs in prevention of gastric cancer. , 2006, World journal of gastroenterology.

[165]  A. Ristimäki,et al.  Early-onset gastric cancers have a different molecular expression profile than conventional gastric cancers , 2006, Modern Pathology.

[166]  H. Friess,et al.  Molecular characterisation of pancreatic ductal adenocarcinoma in patients under 40 , 2006, Journal of Clinical Pathology.

[167]  R. DePinho,et al.  Endogenous oncogenic K-ras(G12D) stimulates proliferation and widespread neoplastic and developmental defects. , 2004, Cancer cell.

[168]  Alison P. Klein,et al.  Prospective Risk of Pancreatic Cancer in Familial Pancreatic Cancer Kindreds , 2004, Cancer Research.

[169]  H. Medina-Franco,et al.  Clinicopathologic characteristics of gastric cancer in a young patient population , 2004, Journal of Gastrointestinal Surgery.

[170]  P. Peltomäki.  Role of DNA mismatch repair defects in the pathogenesis of human cancer. , 2003, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[171]  W. H. Kim,et al.  Alteration of E‐cadherin‐mediated adhesion protein is common, but microsatellite instability is uncommon in young age gastric cancers , 2003, Histopathology.

[172]  N. Le,et al.  Carcinogenic and endocrine disrupting effects of cigarette smoke and risk of breast cancer , 2002, The Lancet.

[173]  K. Cooney,et al.  Early onset prostate cancer: predictors of clinical grade. , 2002, The Journal of urology.

[174]  A. Kokkola,et al.  Gastric carcinoma in young adults. , 2001, Hepato-gastroenterology.

[175]  C K Redmond,et al.  Tamoxifen for prevention of breast cancer: report of the National Surgical Adjuvant Breast and Bowel Project P-1 Study. , 1999, Journal of the National Cancer Institute.

[176]  M. Rugge,et al.  Patients younger than 40 years with gastric carcinoma , 1999, Cancer.

[177]  N. Day,et al.  Family history and the risk of breast cancer: A systematic review and meta‐analysis , 1997, International journal of cancer.

[178]  R. Walker,et al.  Breast carcinomas occurring in young women (< 35 years) are different. , 1996, British Journal of Cancer.

[179]  D. Dent,et al.  Gastric Carcinoma in Young Adults , 1988, Annals of surgery.

[180]  M. Myers,et al.  AGE DISTRIBUTION OF EPITHELIAL AND NON-EPITHELIAL CANCERS , 1983, The Lancet.

[181]  R. Paluri,et al.  Predictors of Survival among Early Onset Pancreatic Adenocarcinoma Patients A Tertiary Care Center Experience. , 2021, Chirurgia.

[182]  C. Joshu,et al.  Early Life Exposures and Adult Cancer Risk , 2017, Epidemiologic reviews.

[183]  A. Bleyer,et al.  Increased risk of second malignant neoplasms in adolescents and young adults with cancer , 2016, Cancer.

[184]  J. Cameron,et al.  Young Patients Undergoing Resection of Pancreatic Cancer Fare Better than their Older Counterparts , 2012, Journal of Gastrointestinal Surgery.

[185]  R. Andersson,et al.  Early onset pancreatic cancer: a controlled trial , 2011, Annals of gastroenterology.

[186]  M. Desmeules,et al.  Energy intake, physical activity, energy balance, and cancer: epidemiologic evidence. , 2009, Methods in molecular biology.

[187]  H. Lynch,et al.  Pancreatic cancer and the FAMMM syndrome , 2007, Familial Cancer.

[188]  H. Lynch,et al.  Hereditary colorectal cancer syndromes: molecular genetics, genetic counseling, diagnosis and management , 2007, Familial Cancer.

[189]  Julian P T Higgins,et al.  Relative and absolute risk of colorectal cancer for individuals with a family history: a meta-analysis. , 2006, European journal of cancer.

[190]  M. Heslin,et al.  Clinicopathological Characteristics of Gastric Carcinoma in Young and Elderly Patients: A Comparative Study , 2000, Annals of Surgical Oncology.