Use of porous biodegradable polymer implants in meniscus reconstruction. 2) Biological evaluation of porous biodegradable polymer implants in menisci

Several series of porous, biodegradable PU/PLLA foams were used for meniscus reconstruction in dogs. PLLA-fiber reinforced PU/PLLA composites, PU/PLLA, and PU foams were implanted in severe meniscus lesions. The healing process was initiated as a result of blood vessels′ and other cells′ ingrowth into these porous materials. To accomplish good ingrowth of fibrocartilaginous tissue, the materials should have interconnected macropores of 200–300μn with a high total pore volume. PLLA fibers were used to reinforce the materials, but seem to retard the degradation process and the ingrowth of fibrocartilaginous tissue.

[1]  E. Weibel.  Stereological Methods. Practical methods for biological morphometry , 1979 .

[2]  R. Warren,et al.  The microvasculature of the meniscus and its response to injury , 1983, The American journal of sports medicine.

[3]  P Ghosh,et al.  The knee joint meniscus , 1987 .

[4]  R. Webber,et al.  Cell culture of rabbit meniscal fibrochondrocytes: Proliferative and synthetic response to growth factors and ascorbate , 1985, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[5]  S. Gogolewski,et al.  Biodegradable materials of poly(l-lactic acid): 1. Melt-spun and solution-spun fibres , 1982 .

[6]  I. R. Toranto,et al.  Bone growth into porous carbon, polyethylene, and polypropylene prostheses. , 1975, Journal of biomedical materials research.

[7]  A. Weinstein,et al.  The role of porous polymeric materials in prosthesis attachment. , 1974, Journal of biomedical materials research.

[8]  M. Spector,et al.  A high-modulus polymer for porous orthopedic implants: biomechanical compatibility of porous implants. , 1978, Journal of biomedical materials research.

[9]  R. Veth,et al.  A POROUS COMPOSITE, BASED ON A BIODEGRADABLE POLY(L-LACTIDE)-POLYURETHANE MATRIX AND REINFORCED WITH CARBON-FIBERS, FOR RECONSTRUCTION OF MENISCUS LESIONS , 1984 .

[10]  T. Taylor,et al.  Effect of postoperative immobilisation on the regrowth of the knee joint semilunar cartilage: An experimental study , 1983, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[11]  R. Webber,et al.  Serum‐free culture of rabbit meniscal fibrochondrocytes: Proliferative response , 1988, Journal of orthopaedic research : official publication of the Orthopaedic Research Society.

[12]  A Rosenklint,et al.  Long-term follow-up of meniscectomy in athletes. A prospective longitudinal study. , 1987, The Journal of bone and joint surgery. British volume.

[13]  A. M. Lutfi.  Morphological changes in the articular cartilage after meniscectomy. An experimental study in the monkey. , 1975, The Journal of bone and joint surgery. British volume.

[14]  C. E. Henning,et al.  Vascularity for healing of meniscus repairs. , 1987, Arthroscopy : the journal of arthroscopic & related surgery : official publication of the Arthroscopy Association of North America and the International Arthroscopy Association.

[15]  R. Warren,et al.  Meniscal repair using an exogenous fibrin clot. An experimental study in dogs. , 1988, The Journal of bone and joint surgery. American volume.

[16]  J. W. Leenslag,et al.  Resorbable materials of poly(L‐lactide). V. Influence of secondary structure on the mechanical properties and hydrolyzability of poly(L‐lactide) fibers produced by a dry‐spinning method , 1984 .