The influence of normal aging and Alzheimer's disease in autobiographical memory highly related to the self.

OBJECTIVE Autobiographical memory (AM) comprises autobiographical episodes (AE) and personal semantics (PS). Self-defining memories (SDMs) represent peculiar memories highly relevant to personality processes and constitute crucial source for the self. To date, no research has compared normal and pathological age-related changes in the AE and PS aspects of AM (including SDMs) and their link with the self. METHOD Young adults, older adults, and patients with Alzheimer's disease (AD) were asked to retrieve 10 AEs, 10 PSs, and 10 SDMs based on identical cue-words and to complete a subjective self-concept scale measuring the degree of certainty and the valence of the self. Memory performance was evaluated for specificity and for emotional valence using quantitative scoring based on standard neuropsychological assessments. RESULTS Compared with young adults, older adults and AD patients demonstrated a deficit in AE; nevertheless, the three groups performed equally for PS. Remarkably, older adults did not differ from young adults for SDMs characterized by high episodicity (SDMe), unlike AD patients. Concerning the self-concept scale, the valence of the self was more positive in healthy subjects than in AD patients, the latter showing higher scores for the degree of certainty. Self-concept measures were correlated with AM scores, especially SDMe, in young and older subjects but not in AD patients. CONCLUSION The implication of these findings is discussed to portray the differences between normal aging and AD concerning the link between AM and the self.

[1]  Pascale Piolino,et al.  Episodic and semantic remote autobiographical memory in ageing , 2002, Memory.

[2]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[3]  L. Clare,et al.  Awareness of memory functioning, autobiographical memory and identity in early-stage dementia , 2008, Neuropsychological rehabilitation.

[4]  Alana T. Wong,et al.  Age-Related Changes in the Episodic Simulation of Future Events , 2008, Psychological science.

[5]  D. Schacter,et al.  Age-related neural changes in autobiographical remembering and imagining , 2011, Neuropsychologia.

[6]  B. Desgranges,et al.  [Physiopathology of autobiographical memory in aging: episodic and semantic distinction, clinical findings and neuroimaging studies]. , 2010, Biologie aujourd'hui.

[7]  A. Beck,et al.  Comparison of Beck Depression Inventories -IA and -II in psychiatric outpatients. , 1996, Journal of personality assessment.

[8]  J. Hodges,et al.  Differentiating the roles of the hippocampal complex and the neocortex in long-term memory storage: evidence from the study of semantic dementia and Alzheimer's disease. , 1997, Neuropsychology.

[9]  G. Eschweiler,et al.  Impairment of episodic and semantic autobiographical memory in patients with mild cognitive impairment and early Alzheimer's disease , 2009, Neuropsychologia.

[10]  Muireann Irish,et al.  Impaired capacity for autonoetic reliving during autobiographical event recall in mild Alzheimer's disease , 2011, Cortex.

[11]  M. Hornberger,et al.  Profiles of recent autobiographical memory retrieval in semantic dementia, behavioural-variant frontotemporal dementia, and Alzheimer's disease , 2011, Neuropsychologia.

[12]  Morris Moscovitch,et al.  Episodic, but not semantic, autobiographical memory is reduced in amnestic mild cognitive impairment , 2008, Neuropsychologia.

[13]  J. Singer,et al.  Four dimensions of self-defining memories (specificity, meaning, content, and affect) and their relationships to self-restraint, distress, and repressive defensiveness. , 2004, Journal of personality.

[14]  Kristi A. Costabile,et al.  Dementia PRESERVED KNOWLEDGE OF SELF IN A CASE OF ALZHEIMER ’ S DEMENTIA , 2003 .

[15]  J M Gardiner,et al.  Changes in memory awareness during learning: the acquisition of knowledge by psychology undergraduates. , 1997, Journal of experimental psychology. General.

[16]  D. Rubin,et al.  Emotionally charged autobiographical memories across the life span: the recall of happy, sad, traumatic, and involuntary memories. , 2002, Psychology and aging.

[17]  Differentiating Roles , 1978 .

[18]  R. Reitan.  Validity of the Trail Making Test as an Indicator of Organic Brain Damage , 1958 .

[19]  Michael Conway,et al.  Subjective impact, meaning making, and current and recalled emotions for self-defining memories. , 2006, Journal of personality.

[20]  Myra A. Fernandes,et al.  Are the memories of older adults positively biased? , 2008, Psychology and aging.

[21]  A. Venneri,et al.  Patterns of impairment in autobiographical memory in the degenerative dementias constrain models of memory , 2006, Neuropsychologia.

[22]  Kate C. McLean,et al.  When remembering is not enough: reflecting on self-defining memories in late adolescence. , 2004, Journal of personality.

[23]  Brian Levine,et al.  The Functional Neuroanatomy of Episodic and Semantic Autobiographical Remembering: A Prospective Functional MRI Study , 2004, Journal of Cognitive Neuroscience.

[24]  K. Werheid,et al.  Familiar smiling faces in Alzheimer's disease: Understanding the positivity-related recognition bias , 2011, Neuropsychologia.

[25]  E. Tulving.  How many memory systems are there , 1985 .

[26]  S. Klein,et al.  Annals of the New York Academy of Sciences the Multiplicity of Self: Neuropsychological Evidence and Its Implications for the Self as a Construct in Psychological Research , 2022 .

[27]  B. Desgranges,et al.  Autobiographical Memory and Autoneotic Consciousness in a case of Semantic Dementia , 2003, Cognitive neuropsychology.

[28]  Juan Pedro Serrano,et al.  Life review therapy using autobiographical retrieval practice for older adults with depressive symptomatology. , 2004, Psychology and aging.

[29]  Alisha C. Holland,et al.  Emotion and autobiographical memory. , 2010, Physics of life reviews.

[30]  Kristi A. Costabile,et al.  Preserved Knowledge of Self in a Case of Alzheimer's Dementia , 2003 .

[31]  S. Folstein,et al.  "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. , 1975, Journal of psychiatric research.

[32]  C J Orona,et al.  Temporality and identity loss due to Alzheimer's disease. , 1990, Social science & medicine.

[33]  J. Singer,et al.  Older, wiser, and happier? Comparing older adults’ and college students’ self-defining memories , 2007, Memory.

[34]  Mara Mather,et al.  The Role of Motivation in the Age-Related Positivity Effect in Autobiographical Memory , 2004, Psychological science.

[35]  Pascale Piolino,et al.  Episodic autobiographical memories over the course of time: Cognitive, neuropsychological and neuroimaging findings , 2009, Neuropsychologia.

[36]  Brian Levine,et al.  Ageing and autobiographical memory for emotional and neutral events , 2007, Memory.

[37]  R. Morris,et al.  The heterogeneity of anosognosia for memory impairment in Alzheimer's disease: A review of the literature and a proposed model , 1998 .

[38]  J. Hodges,et al.  Identification of famous faces and famous names in early Alzheimer's disease. Relationship to anterograde episodic and general semantic memory. , 1996, Brain : a journal of neurology.

[39]  Arnaud D'Argembeau,et al.  PHENOMENAL CHARACTERISTICS OF AUTOBIOGRAPHICAL MEMORIES FOR EMOTIONAL AND NEUTRAL EVENTS IN OLDER AND YOUNGER ADULTS , 2005, Experimental aging research.

[40]  A D Baddeley,et al.  The autobiographical memory interview: a new assessment of autobiographical and personal semantic memory in amnesic patients. , 1989, Journal of clinical and experimental neuropsychology.

[41]  Peter Salovey,et al.  The Remembered Self: Emotion and Memory in Personality , 1993 .

[42]  Michael S. Humphreys,et al.  Contexts and control operations used in accessing list-specific, generalized, and semantic memories , 2009, Cognitive Psychology.

[43]  Martin A. Conway,et al.  Memory and the self , 2005 .

[44]  B. Desgranges,et al.  Autobiographical memory, autonoetic consciousness, and self-perspective in aging. , 2006, Psychology and aging.

[45]  Lisa Feldman Barrett,et al.  Reduced Specificity of Autobiographical Memory and Depression , 2007, Journal of experimental psychology. General.

[46]  P. Maeder,et al.  Functional independence within the self-memory system: New insights from two cases of developmental amnesia , 2013, Cortex.

[47]  M. D’Esposito.  Working memory. , 2008, Handbook of clinical neurology.

[48]  Susan Bluck,et al.  Autobiographical memory: Exploring its functions in everyday life , 2003, Memory.

[49]  B. Wilson.  Neuropsychological Rehabilitation , 1988, Springer US.

[50]  Dale J. Prediger,et al.  Coefficient Kappa: Some Uses, Misuses, and Alternatives , 1981 .

[51]  C. V. van Heugten,et al.  Awareness of memory functioning in patients with stroke who have a good functional outcome , 2014, Brain injury.

[52]  M. Mather,et al.  Aging and motivated cognition: the positivity effect in attention and memory , 2005, Trends in Cognitive Sciences.

[53]  N. Alea,et al.  The Content of Older Adults’ Autobiographical Memories Predicts the Beneficial Outcomes of Reminiscence Group Participation , 2010 .

[54]  M. Conway,et al.  The construction of autobiographical memories in the self-memory system. , 2000, Psychological review.

[55]  Jolanda Jetten,et al.  Declining autobiographical memory and the loss of identity: Effects on well-being , 2010, Journal of clinical and experimental neuropsychology.

[56]  J. Houeto,et al.  Alzheimer’s disease and impairment of the Self , 2010, Consciousness and Cognition.

[57]  V. Holthoff,et al.  Overgenerality of autobiographical memory in people with amnestic mild cognitive impairment and early Alzheimer's disease. , 2010, Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists.

[58]  Daniel L. Schacter,et al.  Priming of semantic autobiographical knowledge: A case study of retrograde amnesia , 1988, Brain and Cognition.

[59]  Pascale Piolino,et al.  Neural substrates of the self‐memory system: New insights from a meta‐analysis , 2013, Human brain mapping.

[60]  Matthew B. Miles,et al.  Temporality and Identity Loss Due to Alzheimer's Disease , 2002 .

[61]  J. Cohen-Mansfield,et al.  Self-identity in older persons suffering from dementia: preliminary results. , 2000, Social science & medicine.

[62]  M. Ross,et al.  The identity function of autobiographical memory: Time is on our side , 2003, Memory.

[63]  Adrian Ivanoiu,et al.  Retrieval of Episodic and Semantic Autobiographical Memories in Early Alzheimer's Disease and Semantic Dementia , 2004, Cortex.

[64]  Martin A. Conway,et al.  The Self and Autobiographical Memory: Correspondence and Coherence , 2004 .

[65]  K.Brading yan.  Advance Online Publications of Academic Journals , 2012 .

[66]  S. Belleville,et al.  Reduced specificity of autobiographical memory and aging: Do the executive and feature binding functions of working memory have a role? , 2010, Neuropsychologia.

[67]  M. Conway,et al.  Images and goals , 2004, Memory.

[68]  F. Eustache,et al.  Self multidimensionnel, mémoire autobiographique et vieillissement , 2007 .

[69]  M. Conway.  Episodic memories , 2009, Neuropsychologia.

[70]  Morris Moscovitch,et al.  Characterizing spatial and temporal features of autobiographical memory retrieval networks: a partial least squares approach , 2004, NeuroImage.

[71]  J. Raaijmakers,et al.  Alzheimer's Disease Versus Normal Ageing: A Review of the Efficiency of Clinical and Experimental Memory Measures , 2003, Journal of clinical and experimental neuropsychology.

[72]  L. Tippett,et al.  Memory of myself: Autobiographical memory and identity in Alzheimer's disease , 2004, Memory.

[73]  F. Eustache,et al.  [Multidimensional Self, autobiographical memory and aging]. , 2007, Psychologie & neuropsychiatrie du vieillissement.

[74]  M. Kopelman.  Storage, forgetting, and retrieval in the anterograde and retrograde amnesia of Alzheimer dementia , 1992 .

[75]  Endel Tulving,et al.  Varieties of consciousness and levels of awareness in memory. , 1993 .

[76]  A. Baddeley,et al.  Autobiographical memory and executive function in early dementia of Alzheimer type , 1995, Neuropsychologia.

[77]  G. Winocur,et al.  Aging and autobiographical memory: dissociating episodic from semantic retrieval. , 2002, Psychology and aging.

[78]  E. Tulving.  [Episodic memory: from mind to brain]. , 2004, Revue neurologique.

[79]  J. Baron,et al.  'In the course of time': a PET study of the cerebral substrates of autobiographical amnesia in Alzheimer's disease. , 2004, Brain : a journal of neurology.

[80]  Guillén Fernández,et al.  Autobiographical memory retrieval in patients with Alzheimer's disease , 2010, NeuroImage.

[81]  Kate C. McLean,et al.  Stories of the young and the old: personal continuity and narrative identity. , 2008, Developmental psychology.