Understanding lactate sensing and signalling
暂无分享,去创建一个
[1] J Zhang,et al. Positive feedback regulation of microglial glucose metabolism by histone H4 lysine 12 lactylation in Alzheimer's disease. , 2022, Cell metabolism.
[2] Li-quan Zhou,et al. Lactate Activates Germline and Cleavage Embryo Genes in Mouse Embryonic Stem Cells , 2022, Cells.
[3] C. Manosalva,et al. Role of Lactate in Inflammatory Processes: Friend or Foe , 2022, Frontiers in Immunology.
[4] Panpan Chang,et al. Lactylated Histone H3K18 as a Potential Biomarker for the Diagnosis and Predicting the Severity of Septic Shock , 2022, Frontiers in Immunology.
[5] Peijun Wang,et al. Hypoxic in vitro culture reduces histone lactylation and impairs pre-implantation embryonic development in mice , 2021, Epigenetics & chromatin.
[6] Juan Liu,et al. A proteomic atlas of ligand–receptor interactions at the ovine maternal–fetal interface reveals the role of histone lactylation in uterine remodeling , 2021, The Journal of biological chemistry.
[7] K. McMasters,et al. Lactate supports a metabolic-epigenetic link in macrophage polarization , 2021, Science advances.
[8] Ning Jiang,et al. Protein Lactylation Critically Regulates Energy Metabolism in the Protozoan Parasite Trypanosoma brucei , 2021, Frontiers in Cell and Developmental Biology.
[9] Pei Zhang,et al. Lactate in the tumour microenvironment: From immune modulation to therapy , 2021, EBioMedicine.
[10] Yaqian Qu,et al. The Role of cAMP-PKA Pathway in Lactate-Induced Intramuscular Triglyceride Accumulation and Mitochondria Content Increase in Mice , 2021, Frontiers in Physiology.
[11] Jiyoun Lee,et al. The macrophage odorant receptor Olfr78 mediates the lactate-induced M2 phenotype of tumor-associated macrophages , 2021, Proceedings of the National Academy of Sciences.
[12] D. Thickett,et al. Lactate cross-talk in host–pathogen interactions , 2021, The Biochemical journal.
[13] Yanfeng Gao,et al. Dual Blockade of Lactate/GPR81 and PD-1/PD-L1 Pathways Enhances the Anti-Tumor Effects of Metformin , 2021, Biomolecules.
[14] Kangdong Liu,et al. FSL-Kla: A few-shot learning-based multi-feature hybrid system for lactylation site prediction , 2021, Computational and structural biotechnology journal.
[15] David L. Williams,et al. Lactate promotes macrophage HMGB1 lactylation, acetylation, and exosomal release in polymicrobial sepsis , 2021, Cell death and differentiation.
[16] Xiaoxi Meng,et al. Comprehensive Analysis of Lysine Lactylation in Rice (Oryza sativa) Grains. , 2021, Journal of agricultural and food chemistry.
[17] Ping Chen,et al. C. tropicalis promotes chemotherapy resistance in colon cancer through increasing lactate production to regulate the mismatch repair system , 2021, International journal of biological sciences.
[18] Qianqian Wang,et al. Acidic pH irreversibly activates the signaling enzyme SARM1 , 2021, The FEBS journal.
[19] Li Sun,et al. Lactate Modulates Cellular Metabolism Through Histone Lactylation-Mediated Gene Expression in Non-Small Cell Lung Cancer , 2021, Frontiers in Oncology.
[20] J. Scheller,et al. Lactate and IL6 define separable paths of inflammatory metabolic adaptation , 2021, Science Advances.
[21] P. Magistretti,et al. Hydroxycarboxylic Acid Receptor 1 and Neuroprotection in a Mouse Model of Cerebral Ischemia-Reperfusion , 2021, Frontiers in Physiology.
[22] Y. Cong,et al. L‐lactate promotes intestinal epithelial cell migration to inhibit colitis , 2021, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.
[23] Yingming Zhao,et al. Class I histone deacetylases (HDAC1–3) are histone lysine delactylases , 2021, bioRxiv.
[24] Xianqun Fan,et al. Histone lactylation drives oncogenesis by facilitating m6A reader protein YTHDF2 expression in ocular melanoma , 2021, Genome biology.
[25] C. Manosalva,et al. Metabolic Reprogramming and Inflammatory Response Induced by D-Lactate in Bovine Fibroblast-Like Synoviocytes Depends on HIF-1 Activity , 2021, Frontiers in Veterinary Science.
[26] G. Petzinger,et al. Exogenous l‐lactate promotes astrocyte plasticity but is not sufficient for enhancing striatal synaptogenesis or motor behavior in mice , 2021, Journal of neuroscience research.
[27] Tae-Yoon Lee. Lactate: a multifunctional signaling molecule , 2021, Yeungnam University journal of medicine.
[28] H. Shoji,et al. Protein lactylation induced by neural excitation , 2021, bioRxiv.
[29] S. Struyf,et al. Studying Neutrophil Function in vitro: Cell Models and Environmental Factors , 2021, Journal of inflammation research.
[30] Wei Chen,et al. Dietary Lactate Supplementation Protects against Obesity by Promoting Adipose Browning in Mice. , 2020, Journal of agricultural and food chemistry.
[31] J. Storm-Mathisen,et al. L‐lactate induces neurogenesis in the mouse ventricular‐subventricular zone via the lactate receptor HCA1 , 2020, Acta physiologica.
[32] Viral G. Jain,et al. TLR signaling adapter BCAP regulates inflammatory to reparatory macrophage transition by promoting histone lactylation , 2020, Proceedings of the National Academy of Sciences.
[33] T. Wynn,et al. Fibrosis: from mechanisms to medicines , 2020, Nature.
[34] W. Liang,et al. Systematic Analysis of Lysine Lactylation in the Plant Fungal Pathogen Botrytis cinerea , 2020, Frontiers in Microbiology.
[35] Gang Liu,et al. Lung Myofibroblast Promote Macrophage Pro-fibrotic Activity Through Lactate-induced Histone Lactylation. , 2020, American journal of respiratory cell and molecular biology.
[36] David L. Williams,et al. Lactate Suppresses Macrophage Pro-Inflammatory Response to LPS Stimulation by Inhibition of YAP and NF-κB Activation via GPR81-Mediated Signaling , 2020, Frontiers in Immunology.
[37] Yuli Lin,et al. Lactate-Modulated Immunosuppression of Myeloid-Derived Suppressor Cells Contributes to the Radioresistance of Pancreatic Cancer , 2020, Cancer Immunology Research.
[38] Ping-Chih Ho,et al. Lactate modulation of immune responses in inflammatory versus tumour microenvironments , 2020, Nature Reviews Immunology.
[39] G. Pan,et al. Glis1 facilitates induction of pluripotency via an epigenome–metabolome–epigenome signalling cascade , 2020, Nature Metabolism.
[40] S. Itzkovitz,et al. Lactate released by inflammatory bone marrow neutrophils induces their mobilization via endothelial GPR81 signaling , 2020, Nature Communications.
[41] R. Gillies,et al. T-cells produce acidic niches in lymph nodes to suppress their own effector functions , 2020, Nature Communications.
[42] Shouxin Li,et al. L-lactate preconditioning promotes plasticity-related proteins expression and reduces neurological deficits by potentiating GPR81 signaling in rat traumatic brain injury model , 2020, Brain Research.
[43] C. Manosalva,et al. Glycolysis and mitochondrial function regulate the radical oxygen species production induced by platelet-activating factor in bovine polymorphonuclear leukocytes. , 2020, Veterinary immunology and immunopathology.
[44] A. M. Kozlov,et al. Lactate preconditioning promotes a HIF-1α-mediated metabolic shift from OXPHOS to glycolysis in normal human diploid fibroblasts , 2020, Scientific Reports.
[45] J. Rathmell,et al. Immunometabolism: From basic mechanisms to translation , 2020, Immunological reviews.
[46] Thomas A. Hopf,et al. Meltome atlas—thermal proteome stability across the tree of life , 2020, Nature Methods.
[47] D. Webb,et al. Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation , 2020, Hypertension.
[48] F. Baltazar,et al. Lactate Beyond a Waste Metabolite: Metabolic Affairs and Signaling in Malignancy , 2020, Frontiers in Oncology.
[49] V. Ganapathy,et al. The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment , 2020, Oncogene.
[50] C. Dickson,et al. Differential effects of L- and D-lactate on memory encoding and consolidation: Potential role of HCAR1 signaling , 2019, Neurobiology of Learning and Memory.
[51] Baixi Shan,et al. Gut microbiome-derived lactate promotes to anxiety-like behaviors through GPR81 receptor-mediated lipid metabolism pathway , 2019, Psychoneuroendocrinology.
[52] A. Devin,et al. Neutrophil Metabolic Shift during Their Lifecycle: Impact on Their Survival and Activation , 2019, International journal of molecular sciences.
[53] S. Mazurek,et al. Metabolic requirements of Besnoitia besnoiti tachyzoite-triggered NETosis , 2019, Parasitology Research.
[54] A. Irving,et al. N‐Palmitoylglycine and other N‐acylamides activate the lipid receptor G2A/GPR132 , 2019, Pharmacology research & perspectives.
[55] K. Mills,et al. Pharmacological Activation of Pyruvate Kinase M2 Inhibits CD4+ T Cell Pathogenicity and Suppresses Autoimmunity , 2019, Cell metabolism.
[56] J. Manzo-Merino,et al. Lactate in the Regulation of Tumor Microenvironment and Therapeutic Approaches , 2019, Front. Oncol..
[57] M. Ruscica,et al. Lactate Buildup at the Site of Chronic Inflammation Promotes Disease by Inducing CD4+ T Cell Metabolic Rewiring , 2019, Cell metabolism.
[58] B. Ren,et al. Metabolic regulation of gene expression by histone lactylation , 2019, Nature.
[59] G. Mitchell,et al. Müller Cell-Localized GPR81 (HCA1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways. , 2019, The American journal of pathology.
[60] Yan Han,et al. Activation of GPR81 by lactate inhibits oscillatory shear stress‐induced endothelial inflammation by activating the expression of KLF2 , 2019, IUBMB life.
[61] S. Chattopadhyay,et al. Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells , 2019, Front. Immunol..
[62] R. Russell,et al. Illuminating G-Protein-Coupling Selectivity of GPCRs , 2019, Cell.
[63] Junbo Hu,et al. Lactate Is a Natural Suppressor of RLR Signaling by Targeting MAVS , 2019, Cell.
[64] A. Rocher,et al. The Lactate Receptor HCAR1 Modulates Neuronal Network Activity through the Activation of Gα and Gβγ Subunits , 2019, The Journal of Neuroscience.
[65] L. Bergersen,et al. Dual Properties of Lactate in Müller Cells: The Effect of GPR81 Activation. , 2019, Investigative ophthalmology & visual science.
[66] G. Mitchell,et al. Müller Cell-Localized GPR81 (HCA1) Regulates Inner Retinal Vasculature via Norrin/Wnt Pathways. , 2019, The American journal of pathology.
[67] K. S. Kim,et al. Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development. , 2018, Cell host & microbe.
[68] D. Inman,et al. Reduced AMPK activation and increased HCAR activation drive anti-inflammatory response and neuroprotection in glaucoma , 2018, Journal of Neuroinflammation.
[69] G. Hooiveld,et al. In vitro and in vivo Effects of Lactate on Metabolism and Cytokine Production of Human Primary PBMCs and Monocytes , 2018, Front. Immunol..
[70] V. Pucino,et al. Lactate transporters as therapeutic targets in cancer and inflammatory diseases , 2018, Expert opinion on therapeutic targets.
[71] Xiuxia Qu,et al. Lactate enhanced the effect of parathyroid hormone on osteoblast differentiation via GPR81-PKC-Akt signaling. , 2018, Biochemical and biophysical research communications.
[72] D. Welsh,et al. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR , 2018, Cell.
[73] L. Zon,et al. Specific oxylipins enhance vertebrate hematopoiesis via the receptor GPR132 , 2018, Proceedings of the National Academy of Sciences.
[74] B. Berwin,et al. Acidosis exacerbates in vivo IL-1-dependent inflammatory responses and neutrophil recruitment during pulmonary Pseudomonas aeruginosa infection. , 2018, American journal of physiology. Lung cellular and molecular physiology.
[75] V. Ganapathy,et al. GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis , 2018, The Journal of Immunology.
[76] O. Fjellström,et al. Involvement of the metabolic sensor GPR81 in cardiovascular control. , 2017, JCI insight.
[77] W. Wagner,et al. The lactate receptor (HCAR1/GPR81) contributes to doxorubicin chemoresistance via ABCB1 transporter up-regulation in human cervical cancer HeLa cells. , 2017, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.
[78] H. Yang,et al. Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells , 2017, Oncogene.
[79] D. Wallace,et al. Foxp3 Reprograms T Cell Metabolism to Function in Low-Glucose, High-Lactate Environments. , 2017, Cell metabolism.
[80] Olga Rudenko,et al. GPCR-Mediated Signaling of Metabolites. , 2017, Cell metabolism.
[81] W. Wagner,et al. Stimulation of lactate receptor (HCAR1) affects cellular DNA repair capacity. , 2017, DNA repair.
[82] X. Hou,et al. Lactate produced during labor modulates uterine inflammation via GPR81 (HCA1) , 2017, American journal of obstetrics and gynecology.
[83] M. Neurath,et al. Ménage-à-Trois: The Ratio of Bicarbonate to CO2 and the pH Regulate the Capacity of Neutrophils to Form NETs , 2016, Front. Immunol..
[84] J. Sirard,et al. Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner , 2016, PloS one.
[85] D. Noh,et al. G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion , 2016, Oncotarget.
[86] R. Dey,et al. Regulation, Signaling, and Physiological Functions of G-Proteins. , 2016, Journal of molecular biology.
[87] J. Storm-Mathisen,et al. Lactate Transport and Receptor Actions in Retina: Potential Roles in Retinal Function and Disease , 2015, Neurochemical Research.
[88] O. Mazda,et al. Monocarboxylate Transporter 4, Associated With the Acidification of Synovial Fluid, Is a Novel Therapeutic Target for Inflammatory Arthritis , 2015, Arthritis & rheumatology.
[89] R. Gillies,et al. Abstract 3213: Extracellular acidosis alters polarization of macrophages , 2015 .
[90] F. D’Acquisto,et al. Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions , 2015, PLoS biology.
[91] Maja A. Puchades,et al. The lactate receptor, G‐protein‐coupled receptor 81/hydroxycarboxylic acid receptor 1: Expression and action in brain , 2015, Journal of neuroscience research.
[92] Sang J. Chung,et al. A Lactate-Induced Response to Hypoxia , 2015, Cell.
[93] N. Lu,et al. Lactate promotes PGE2 synthesis and gluconeogenesis in monocytes to benefit the growth of inflammation-associated colorectal tumor , 2015, Oncotarget.
[94] M. Rehli,et al. Lactic acid delays the inflammatory response of human monocytes. , 2015, Biochemical and biophysical research communications.
[95] Nataliya Gorinski,et al. De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells , 2014, Nature Medicine.
[96] Albert Gjedde,et al. Lactate receptor sites link neurotransmission, neurovascular coupling, and brain energy metabolism. , 2014, Cerebral cortex.
[97] G. Cline,et al. Functional polarization of tumour-associated macrophages by tumour-derived lactic acid , 2014, Nature.
[98] W. Burns,et al. Cell surface lactate receptor GPR81 is crucial for cancer cell survival. , 2014, Cancer research.
[99] R. Hoque,et al. Lactate reduces liver and pancreatic injury in Toll-like receptor- and inflammasome-mediated inflammation via GPR81-mediated suppression of innate immunity. , 2014, Gastroenterology.
[100] Gary D Bader,et al. A draft map of the human proteome , 2014, Nature.
[101] Li V. Yang,et al. Acidic tumor microenvironment and pH-sensing G protein-coupled receptors , 2013, Front. Physiol..
[102] J. Puyal,et al. Lactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway , 2013, PloS one.
[103] Z. Husain,et al. Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells , 2013, The Journal of Immunology.
[104] J. Verrax,et al. Lactate Activates HIF-1 in Oxidative but Not in Warburg-Phenotype Human Tumor Cells , 2012, PloS one.
[105] Alessia Ricupito,et al. Modulation of microenvironment acidity reverses anergy in human and murine tumor-infiltrating T lymphocytes. , 2012, Cancer research.
[106] Seung-Yoon Park,et al. Extracellular Low pH Modulates Phosphatidylserine-dependent Phagocytosis in Macrophages by Increasing Stabilin-1 Expression* , 2012, The Journal of Biological Chemistry.
[107] B. Ramsahoye,et al. Lactate, a product of glycolytic metabolism, inhibits histone deacetylase activity and promotes changes in gene expression , 2012, Nucleic acids research.
[108] A. Halestrap,et al. The monocarboxylate transporter family—Role and regulation , 2012, IUBMB life.
[109] T. Lovenberg,et al. Study of GPR81, the Lactate Receptor, from Distant Species Identifies Residues and Motifs Critical for GPR81 Functions , 2011, Molecular Pharmacology.
[110] Stefan Walenta,et al. Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release. , 2011, International journal of oncology.
[111] O. Okorie,et al. Lactate: biomarker and potential therapeutic target. , 2011, Critical care clinics.
[112] S. Tunaru,et al. An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81. , 2010, Cell metabolism.
[113] P. Oefner,et al. Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes , 2009, The Journal of Immunology.
[114] T. Izumi,et al. G2A as a receptor for oxidized free fatty acids. , 2009, Prostaglandins & other lipid mediators.
[115] M. Lopes-Virella,et al. Lactate Boosts TLR4 Signaling and NF-κB Pathway-Mediated Gene Transcription in Macrophages via Monocarboxylate Transporters and MD-2 Up-Regulation1 , 2009, The Journal of Immunology.
[116] F. Kamme,et al. Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81* , 2009, Journal of Biological Chemistry.
[117] S. Kash,et al. Role of GPR81 in lactate-mediated reduction of adipose lipolysis. , 2008, Biochemical and biophysical research communications.
[118] J. Suttles,et al. Adenosine 5′-Monophosphate-Activated Protein Kinase Promotes Macrophage Polarization to an Anti-Inflammatory Functional Phenotype1 , 2008, The Journal of Immunology.
[119] H. Shime,et al. Tumor-Secreted Lactic Acid Promotes IL-23/IL-17 Proinflammatory Pathway1 , 2008, The Journal of Immunology.
[120] C. Chao,et al. Intracellular acidification enhances neutrophil phagocytosis in chronic haemodialysis patients: possible role of CD11b/CD18. , 2008, Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association.
[121] P. Courtoy,et al. Restoring the association of the T cell receptor with CD8 reverses anergy in human tumor-infiltrating lymphocytes. , 2008, Immunity.
[122] Tiago Costa Leite,et al. Lactate favours the dissociation of skeletal muscle 6-phosphofructo-1-kinase tetramers down-regulating the enzyme and muscle glycolysis. , 2007, The Biochemical journal.
[123] Gregor Rothe,et al. Inhibitory effect of tumor cell-derived lactic acid on human T cells. , 2007, Blood.
[124] J. Sabatté,et al. Extracellular Acidosis Induces Neutrophil Activation by a Mechanism Dependent on Activation of Phosphatidylinositol 3-Kinase/Akt and ERK Pathways1 , 2006, The Journal of Immunology.
[125] V. Ganapathy,et al. Cloning and functional identification of slc5a12 as a sodium-coupled low-affinity transporter for monocarboxylates (SMCT2). , 2005, The Biochemical journal.
[126] O. Witte,et al. Differential proton sensitivity of related G protein-coupled receptors T cell death-associated gene 8 and G2A expressed in immune cells. , 2005, Proceedings of the National Academy of Sciences of the United States of America.
[127] C. Cori,et al. THE CARBOHYDRATE METABOLISM OF TUMORS , 2003 .
[128] Otto Warburn,et al. THE METABOLISM OF TUMORS , 1931 .
[129] C. Cori,et al. The Carbohydrate Metabolism of Tumors: III. The Rate of Glycolysis of Tumor Tissue in the Living Animal* , 1928 .
[130] O. Warburg,et al. THE METABOLISM OF TUMORS IN THE BODY , 1927, The Journal of general physiology.