N,N-disubstituted azines attenuate LPS-mediated neuroinflammation in microglia and neuronal apoptosis via inhibiting MAPK signaling pathways

[1]  S. Kim,et al.  Neuroprotective and Anti-Inflammatory Activities of Allyl Isothiocyanate through Attenuation of JNK/NF-κB/TNF-α Signaling , 2017, International journal of molecular sciences.

[2]  S. Kim,et al.  Equol, a Dietary Daidzein Gut Metabolite Attenuates Microglial Activation and Potentiates Neuroprotection In Vitro , 2017, Nutrients.

[3]  M. Do,et al.  Anti-neuroinflammatory and neuroprotective effects of the Lindera neesiana fruit in vitro. , 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[4]  Eloi P Coutant,et al.  Original 2-(3-Alkoxy-1H-pyrazol-1-yl)azines Inhibitors of Human Dihydroorotate Dehydrogenase (DHODH) , 2015, Journal of medicinal chemistry.

[5]  Xianting Ding,et al.  SIRT2 is required for lipopolysaccharide-induced activation of BV2 microglia , 2015, Neuroreport.

[6]  P. Vidalain,et al.  Original 2-(3-alkoxy-1H-pyrazol-1-yl)pyrimidine derivatives as inhibitors of human dihydroorotate dehydrogenase (DHODH). , 2015, Journal of medicinal chemistry.

[7]  ChulHun Kang,et al.  α-Asarone Ameliorates Memory Deficit in Lipopolysaccharide-Treated Mice via Suppression of Pro-Inflammatory Cytokines and Microglial Activation , 2014, Biomolecules & therapeutics.

[8]  Yung-Hyun Choi,et al.  Anthocyanins Downregulate Lipopolysaccharide-Induced Inflammatory Responses in BV2 Microglial Cells by Suppressing the NF-κB and Akt/MAPKs Signaling Pathways , 2013, International journal of molecular sciences.

[9]  P. Han,et al.  Activation of Autophagy Pathway Suppresses the Expression of iNOS, IL6 and Cell Death of LPS-Stimulated Microglia Cells , 2013, Biomolecules & therapeutics.

[10]  Dong Hyun Kim,et al.  6-Shogaol, a ginger product, modulates neuroinflammation: A new approach to neuroprotection , 2012, Neuropharmacology.

[11]  Byeongno Lee,et al.  Synthesis of azines in solid state: reactivity of solid hydrazine with aldehydes and ketones. , 2011, Organic letters.

[12]  S. Bak,et al.  Attenuation of pro-inflammatory mediators in LPS-stimulated BV2 microglia by chitooligosaccharides via the MAPK signaling pathway. , 2011, International journal of biological macromolecules.

[13]  Seung Hee Kang,et al.  Isolation and structural characterization of the elusive 1:1 adduct of hydrazine and carbon dioxide. , 2011, Chemical communications.

[14]  E. Choi,et al.  Pathological roles of MAPK signaling pathways in human diseases. , 2010, Biochimica et biophysica acta.

[15]  D. Baker,et al.  Inflammation in neurodegenerative diseases , 2010, Immunology.

[16]  S. Sugama.  Stress-induced microglial activation may facilitate the progression of neurodegenerative disorders. , 2009, Medical hypotheses.

[17]  S. Rivest.  Regulation of innate immune responses in the brain , 2009, Nature Reviews Immunology.

[18]  P. Gasque,et al.  The Multiple Roles of the Innate Immune System in the Regulation of Apoptosis and Inflammation in the Brain , 2009, Journal of neuropathology and experimental neurology.

[19]  M. Strong,et al.  Tau phosphorylation at threonine‐175 leads to fibril formation and enhanced cell death: implications for amyotrophic lateral sclerosis with cognitive impairment , 2009, Journal of neurochemistry.

[20]  Jing Zhang,et al.  Neuroprotective role of tripchlorolide on inflammatory neurotoxicity induced by lipopolysaccharide-activated microglia. , 2008, Biochemical pharmacology.

[21]  Wenqing Cai,et al.  Small molecule regulators of autophagy identified by an image-based high-throughput screen , 2007, Proceedings of the National Academy of Sciences.

[22]  F. Crews,et al.  Systemic LPS causes chronic neuroinflammation and progressive neurodegeneration , 2007, Glia.

[23]  M. Strong,et al.  Innate immunity in amyotrophic lateral sclerosis. , 2006, Biochimica et biophysica acta.

[24]  B. Kamińska.  MAPK signalling pathways as molecular targets for anti-inflammatory therapy--from molecular mechanisms to therapeutic benefits. , 2005, Biochimica et biophysica acta.

[25]  W. Streit,et al.  Role of microglia in the central nervous system's immune response , 2005, Neurological research.

[26]  T. Postolache,,et al.  Tumor necrosis factor alpha, interleukin-1 beta, interleukin-6 and major histocompatibility complex molecules in the normal brain and after peripheral immune challenge , 2005, Neurological research.

[27]  K. Zhao,et al.  Oxidative Cyclization of Aldazines with Bis(trifluoroacetoxy)iodobenzene. , 2005 .

[28]  L. Minghetti.  Cyclooxygenase‐2 (COX‐2) in Inflammatory and Degenerative Brain Diseases , 2004, Journal of neuropathology and experimental neurology.

[29]  Jongseo Lee,et al.  Neuroprotective effect of wogonin in hippocampal slice culture exposed to oxygen and glucose deprivation. , 2004, European journal of pharmacology.

[30]  P. Majcherczyk,et al.  Proinflammatory Activity of Cell-wall Constituents from Gram-positive Bacteria , 2003, Scandinavian journal of infectious diseases.

[31]  Bin Liu,et al.  Role of Microglia in Inflammation-Mediated Neurodegenerative Diseases: Mechanisms and Strategies for Therapeutic Intervention , 2003, Journal of Pharmacology and Experimental Therapeutics.

[32]  P. Carvey,et al.  Tumor Necrosis Factor α Is Toxic to Embryonic Mesencephalic Dopamine Neurons , 2001, Experimental Neurology.

[33]  C. Iadecola.  Bright and dark sides of nitric oxide in ischemic brain injury , 1997, Trends in Neurosciences.

[34]  J. Mitchell,et al.  Cyclooxygenase-2: regulation and relevance in inflammation. , 1995, Biochemical pharmacology.

[35]  Shuxian Hu,et al.  Modulation of human microglial cell superoxide production by cytokines , 1995, Journal of leukocyte biology.

[36]  S H Snyder,et al.  A novel neuronal messenger molecule in brain: The free radical, nitric oxide , 1992, Annals of neurology.

[37]  R. Andriantsitohaina,et al.  Acetylcholine released from guinea‐pig submucosal neurones dilates arterioles by releasing nitric oxide from endothelium. , 1992, The Journal of physiology.

[38]  H. Eizawa,et al.  Purification of nitric oxide synthase from rat macrophages. , 1991, The Journal of biological chemistry.

[39]  K. Kieć‐Kononowicz,et al.  Azines as histamine H4 receptor antagonists. , 2012, Frontiers in bioscience.

[40]  R. Maccioni,et al.  Neuroinflammation: implications for the pathogenesis and molecular diagnosis of Alzheimer's disease. , 2008, Archives of medical research.

[41]  P. Carvey,et al.  Tumor necrosis factor alpha is toxic to embryonic mesencephalic dopamine neurons. , 2001, Experimental neurology.

[42]  B. Tantisira,et al.  Synthesis of N‐Aryl‐N′‐heteroaryl‐Substituted Urea and Thiourea Derivatives and Evaluation of Their Anticonvulsant Activity , 1997, Archiv der Pharmazie.

[43]  J. Schwartz,et al.  Azines and Diazines as Potential Histamine H3‐Receptor Antagonists , 1995, Archiv der Pharmazie.