Creatine phosphokinase levels in children with severe developmental disturbances.

Serum creatine phosphokinase (CPK) levels were studied in individuals: 40 psychotic children suffering from childhood autism, atypical personality development, and childhood schizophrenia; five children with childhood aphasia; 22 children with severe personality disorders; 29 normal children and normal siblings of psychotic children; and 14 normal parents of psychotic children. Creatine phosphokinase levels from the entire population of adults and children were normally disturbed, and the mean CPK levels for the eight diagnostic groups were within normal limits. Those 22 children with personality disorders had significantly higher CPK levels than the other diagnostic groups. This relatively higher level of CPK may be related to vulnerability to later development of schizophrenic spectrum disorders. There was no apparent relationship between CPK levels and motor activity, nor was there any change in the level of CPK during a trial of psychoactive medication. Creatine phosphokinase levels remained relatively stable on test-retest determination.

[1]  B. Shaywitz,et al.  Biogenic amines in autistic and atypical children. Cerebrospinal fluid measures of homovanillic acid and 5-hydroxyindoleacetic acid. , 1974, Archives of general psychiatry.

[2]  F. Sidell,et al.  Serum creatine phosphokinase activity after intramuscular injection. The effect of dose, concentration, and volume. , 1974, JAMA.

[3]  N. Garmezy,et al.  Children at risk: the search for the antecedents of schizophrenia. Part II: ongoing research programs, issues, and intervention. , 1974, Schizophrenia bulletin.

[4]  H. Meltzer,et al.  Muscle abnormalities in psychotic patients. II. Serum CPK activity, fiber abnormalities, and branching and sprouting of subterminal nerves. , 1974, Biological psychiatry.

[5]  J. Olney,et al.  Creatine Phosphokinase and Psychiatric Illness , 1974, British Journal of Psychiatry.

[6]  D. Kupfer,et al.  Psychomotor activity and serum creatine phosphokinase activity. , 1973, Archives of general psychiatry.

[7]  H. Meltzer.  Central core fibers in an acutely psychotic patient. Evidence for a neurogenic basis for the muscle abnormalities in the acute psychoses. , 1972, Archives of general psychiatry.

[8]  H. Sudak,et al.  Creatine phosphokinase and psychosis. , 1972, Archives of general psychiatry.

[9]  H. Meltzer.  Factors affecting serum creatine phosphokinase levels in the general population: the role of race, activity and age. , 1971, Clinica chimica acta; international journal of clinical chemistry.

[10]  H. Meltzer,et al.  Plasma enzymatic activity after exercise. Study of psychiatric patients and their relatives. , 1970, Archives of general psychiatry.

[11]  D. Kupfer,et al.  Sleep disturbance and serum CPK activity in acute psychosis. , 1970, Archives of general psychiatry.

[12]  H. Meltzer,et al.  Effect of Intramuscular Injections on Serum Creatine Phosphokinase Activity , 1970, The American journal of the medical sciences.

[13]  H. Meltzer,et al.  Serum-Enzyme Changes in Newly Admitted Psychiatric Patients: Part I , 1969 .

[14]  H. Meltzer,et al.  Muscle enzyme release in the acute psychoses. , 1969, Archives of general psychiatry.

[15]  H. Meltzer.  Creatine Kinase and Aldolase in Serum: Abnormality Common to Acute Psychoses , 1968, Science.

[16]  J. Millichap,et al.  Serum creatine phosphokinase activity in epilepsy , 1967, Neurology.

[17]  S. Rosalki.  An improved procedure for serum creatine phosphokinase determination. , 1967, The Journal of laboratory and clinical medicine.

[18]  N. Garmezy,et al.  Children at risk: the search for the antecedents of schizophrenia. Part I. Conceptual models and research methods. , 1974, Schizophrenia bulletin.

[19]  H. Meltzer.  SERUM CREATINE PHOSPHOKINASE AND SERUM ALDOLASE LEVELS IN ACUTELY PSYCHOTIC PATIENTS , 1974 .

[20]  L. Kanner.  Childhood psychosis: initial studies and new insights , 1973 .