Ultrasonic and elasticity imaging to model disease-induced changes in soft-tissue structure

Ultrasonic techniques are presented for the study of soft biological tissue structure and function. Changes in echo waveforms caused by microscopic variations in the mechanical properties of tissue can reveal disease mechanism, in vivo. On a larger scale, elasticity imaging describes the macroscopic mechanical properties of soft tissues. We summarize the approach and present preliminary results for studying disease-induced changes in renal tissue using these two acoustic imaging techniques.

[1]  P. Chaturvedi,et al.  Testing the limitations of 2-D companding for strain imaging using phantoms , 1998, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[2]  F. Dunn,et al.  Ultrasonic Scattering in Biological Tissues , 1992 .

[3]  T J Hall,et al.  Identifying acoustic scattering sources in normal renal parenchyma in vivo by varying arterial and ureteral pressures. , 1992, Ultrasound in medicine & biology.

[4]  Renal Function Assessed by Monitoring the Size of Acoustic Scatterers: Map Estimators and the Use of Prior Information , 1996 .

[5]  Stanislav Emelianov,et al.  Biophysical Bases of Elasticity Imaging , 1995 .

[6]  C. R. Hill,et al.  Ultrasonic study of in vivo kinetic characteristics of human tissues. , 1986, Ultrasound in medicine & biology.

[7]  E J Feleppa,et al.  Diagnostic spectrum analysis in ophthalmology: a physical perspective. , 1986, Ultrasound in medicine & biology.

[8]  R. F. Wagner,et al.  Describing small-scale structure in random media using pulse-echo ultrasound. , 1990, The Journal of the Acoustical Society of America.

[9]  Y. Fung,et al.  Biology of Collagen , 1980 .

[10]  Y. Fung A first course in continuum mechanics , 1969 .

[11]  Y. Fung A first course in continuum mechanics /2nd edition/ , 1977 .

[12]  R C Waag,et al.  Ultrasonic scattering properties of three random media with implications for tissue characterization. , 1984, The Journal of the Acoustical Society of America.

[13]  M. Bilgen,et al.  Deformation models and correlation analysis in elastography. , 1996, The Journal of the Acoustical Society of America.

[14]  J. Zagzebski,et al.  Frequency dependence of backscatter coefficient versus scatterer volume fraction , 1996, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[15]  B Barzilai,et al.  Ultrasonic tissue characterization: integrated backscatter imaging for detecting myocardial structural properties and on-line quantitation of cardiac function. , 1994, American journal of cardiac imaging.

[16]  Mathematical model of progressive renal disease. , 1997, Journal of theoretical biology.

[17]  T J Hall,et al.  Parametric Ultrasound Imaging from Backscatter Coefficient Measurements: Image Formation and Interpretation , 1990, Ultrasonic imaging.

[18]  A. Manduca,et al.  Magnetic resonance elastography by direct visualization of propagating acoustic strain waves. , 1995, Science.

[19]  K J Parker,et al.  Imaging of the elastic properties of tissue--a review. , 1996, Ultrasound in medicine & biology.

[20]  K J Parker,et al.  Tissue response to mechanical vibrations for "sonoelasticity imaging". , 1990, Ultrasound in medicine & biology.

[21]  J. Ophir,et al.  Elastography: A Quantitative Method for Imaging the Elasticity of Biological Tissues , 1991, Ultrasonic imaging.

[22]  A. Fogo,et al.  Effects of antihypertensive drugs on glomerular morphology. , 1989, Kidney international.

[23]  M. O’Donnell,et al.  Internal displacement and strain imaging using ultrasonic speckle tracking , 1994, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[24]  A. Fogo,et al.  Is focal segmental glomerulosclerosis really focal? Distribution of lesions in adults and children. , 1995, Kidney international.

[25]  T. Hall,et al.  2-D companding for noise reduction in strain imaging , 1998, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.

[26]  P. Chaturvedi,et al.  Bayesian and least squares approaches to ultrasonic scatterer size image formation , 1997, IEEE Transactions on Ultrasonics, Ferroelectrics and Frequency Control.