Evolution of high-level daptomycin resistance in Enterococcus faecium during daptomycin therapy is associated with limited mutations in the bacterial genome.

Division of Infectious Diseases, UCLA David Geffen School of Medicine, Los Angeles, CA, USA; Department of Organismic and Evolutionary Biology, Center for Systems Biology, Harvard University, Cambridge, MA, USA; The Broad Institute of the Massachusetts Institute of Technology and Harvard, Cambridge, MA, USA; Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA