Influence of molecular structure on the tolerogenicity of bacterial dextrans

Dextran B1355 induces separate IgM responses in mice against its α(l→3) and a(l→6)‐linked glucosyl linkages. The maximum injectable dose (10 mg) produces α(l→3) immunity and α(l→6) tolerance in the BALB/c strain. The same amount will tolerize the CBA strain for both epitopes, whereas 1 mg will produce α(l→3) tolerance and α(l→6) immunity. The converse dissociation in these strains between tolerance and immunity to the two intrinsic epitopes of dextran B1355 seems, in the face of the corresponding minimum immunogenic doses, incompatible with B cell tolerance mechanisms invoking either an excess of “one nonspecific signal” or lack of a “second signal”.

[1]  G. Vicari,et al.  Restricted avidity of the IgM antibody response to dextran B512 in mice: studies on inhibition of specific plaque forming cells by oligosaccharides. , 1977, Immunochemistry.

[2]  C. Hale,et al.  Lack of neonatal susceptibility to induction of tolerance by polysaccharide antigens , 1976, European journal of immunology.

[3]  M. Feldmann,et al.  Mechanisms of B-cell tolerance. , 1976, British medical bulletin.

[4]  C. Moreno,et al.  Molecular size and structure in relation to the tolerogenicity of small fructosans (levans). , 1976, Immunochemistry.

[5]  G. Chaouat,et al.  Influence of reticuloendothelial blockade on the induction of tolerance and immunity by polysaccharides. , 1976, Immunology.

[6]  S. Svensson,et al.  An improved method for synthesising O-stearoyldextran for the detection of plaque forming cells specific for the α-(1 → 6) determinant , 1976 .

[7]  G. Vicari,et al.  Influence of molecular structure of the tolerogenicity of bacterial dextrans. III. Dissociation between tolerance and immunity to the alpha1--6- and alpha1--3-linked epitopes of dextran B1355. , 1975, Immunology.

[8]  G. Vicari,et al.  Influence of molecular structure on the tolerogenicity of bacterial dextrans. I. The alpha1--6-linked epitope of dextran B512. , 1975, Immunology.

[9]  C DeLisi,et al.  The kinetics of hemolytic plaque formation. IV. IgM plaque inhibition. , 1975, Journal of theoretical biology.

[10]  M. Lukic,et al.  Strain differences in ease of tolerance induction to bovine gamma-globulin: dependence on macrophage function. , 1975, Journal of immunology.

[11]  J. Miranda.  Studies on immunological paralysis. IX. The immunogenicity and tolerogenicity of levan (polyfructose) in mice. , 1972, Immunology.

[12]  H. Zola,et al.  Studies on immunological paralysis. X. Cellular characteristics of the induction and loss of tolerance to levan (Polyfructose). , 1972, Immunology.

[13]  Martin Weigert,et al.  Genetics of the Antibody Response to Dextran in Mice , 1972, Science.

[14]  B. Lewis,et al.  Structure of a (1→3)-α-d-glucan (pseudonigeran) of Aspergillus niger NNRL 326 cell wall , 1972 .

[15]  R. A. Phillips,et al.  A QUANTITATIVE ASSAY FOR THE PROGENITORS OF BONE MARROW-ASSOCIATED LYMPHOCYTES , 1972, The Journal of experimental medicine.

[16]  B. Andersson.  STUDIES ON THE REGULATION OF AVIDITY AT THE LEVEL OF THE SINGLE ANTIBODY-FORMING CELL , 1970, The Journal of experimental medicine.

[17]  M. A. León,et al.  Immunochemical studies of the reaction between a mouse myeloma macroglobulin and dextrans. , 1970, Biochemistry.

[18]  S. Kirkwood,et al.  Enzymes That Hydrolyze Fungal Cell Wall Polysaccharides I. PURIFICATION AND PROPERTIES OF AN ENDO-α-d-(1 → 3)-GLUCANASE FROM TRICHODERMA VIRIDE , 1969 .

[19]  J. Till,et al.  Analysis of Differentiating Clones Derived from Marrow , 1967 .

[20]  I. Johnston.  The partial acid hydrolysis of a highly dextrorotatory fragment of the cell wall of Aspergillus niger. Isolation of the alpha-(1-3)-linked dextrin series. , 1965, The Biochemical journal.

[21]  H. M. Tsuchiya,et al.  Characterization and Classification of Dextrans from Ninety-six Strains of Bacteria1b , 1954 .

[22]  Michael Somogyi,et al.  A NEW REAGENT FOR THE DETERMINATION OF SUGARS , 1945 .