Notch signaling pathway: architecture, disease, and therapeutics

[1]  Susana López-López,et al.  NOTCH4 Exhibits Anti-Inflammatory Activity in Activated Macrophages by Interfering With Interferon-γ and TLR4 Signaling , 2021, Frontiers in Immunology.

[2]  Zhenbo Wang,et al.  Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation , 2021, Cell Death & Differentiation.

[3]  Z. Peng,et al.  Inhibition of Notch activity promotes pancreatic cytokeratin 5-positive cell differentiation to beta cells and improves glucose homeostasis following acute pancreatitis , 2021, Cell Death and Disease.

[4]  A. Fazleabas,et al.  Notch signaling in reproduction , 2021, Trends in Endocrinology & Metabolism.

[5]  P. Durek,et al.  An in vitro platform supports generation of human innate lymphoid cells from CD34+ hematopoietic progenitors that recapitulate ex vivo identity. , 2021, Immunity.

[6]  C. Siebel,et al.  Delta-like 1–Expressing Cells at the Gland Base Promote Proliferation of Gastric Antral Stem Cells in Mouse , 2021, Cellular and molecular gastroenterology and hepatology.

[7]  P. Serup,et al.  Dynamic cell contacts between periportal mesenchyme and ductal epithelium act as a rheostat for liver cell proliferation , 2021, Cell stem cell.

[8]  T. Burns,et al.  Brief Report: A Phase 1 Study Evaluating Rovalpituzumab Tesirine (Rova-T) in Frontline Treatment of Patients With Extensive-Stage Small Cell Lung Cancer. , 2021, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[9]  K. Jacobs,et al.  PSEN1-selective gamma-secretase inhibition in combination with kinase or XPO-1 inhibitors effectively targets T cell acute lymphoblastic leukemia , 2021, Journal of Hematology & Oncology.

[10]  KyeongJin Kim,et al.  Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis , 2021, Science Translational Medicine.

[11]  I. Leclercq,et al.  Notch-IGF1 signaling during liver regeneration drives biliary epithelial cell expansion and inhibits hepatocyte differentiation , 2021, Science Signaling.

[12]  A. López-Guillermo,et al.  Genetic and Phenotypic Attributes of Splenic Marginal Zone Lymphoma. , 2021, Blood.

[13]  Jianhua Zhang,et al.  Whole-Genome Sequencing of Common Salivary Gland Carcinomas: Subtype-Restricted and Shared Genetic Alterations , 2021, Clinical Cancer Research.

[14]  H. Guan,et al.  An RFC4/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness , 2021, Nature Communications.

[15]  Kole T. Roybal,et al.  SynNotch CAR circuits enhance solid tumor recognition and promote persistent antitumor activity in mouse models , 2021, Science Translational Medicine.

[16]  Aileen W. Li,et al.  SynNotch-CAR T cells overcome challenges of specificity, heterogeneity, and persistence in treating glioblastoma , 2021, Science Translational Medicine.

[17]  Melissa L. Johnson,et al.  Rovalpituzumab Tesirine as a Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Patients With Extensive-Stage Small Cell Lung Cancer: Results From the Phase 3 MERU Study. , 2021, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[18]  D. Sprinzak,et al.  Dynamic spatiotemporal coordination of neural stem cell fate decisions occurs through local feedback in the adult vertebrate brain , 2021, Cell stem cell.

[19]  A. Italiano,et al.  A phase 1b study of the Notch inhibitor crenigacestat (LY3039478) in combination with other anticancer target agents (taladegib, LY3023414, or abemaciclib) in patients with advanced or metastatic solid tumors , 2021, Investigational New Drugs.

[20]  Melissa L. Johnson,et al.  A Phase I/II Study of Rovalpituzumab Tesirine in Combination With Nivolumab ± Ipilimumab in Patients With Previously Treated Extensive-Stage Small Cell Lung Cancer. , 2021, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[21]  R. Scheltema,et al.  Notch–Jagged signaling complex defined by an interaction mosaic , 2021, Proceedings of the National Academy of Sciences.

[22]  R. Rad,et al.  Notch2-mediated plasticity between marginal zone and follicular B cells , 2021, Nature Communications.

[23]  K. Nackaerts,et al.  Efficacy and Safety of Rovalpituzumab Tesirine Compared with Topotecan as Second-Line Therapy in DLL3-High Small Cell Lung Cancer: Results from the Phase 3 TAHOE Study. , 2021, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[24]  A. Rosenwald,et al.  Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1. , 2021, Blood.

[25]  G. Kenter,et al.  Delta-Like Ligand–Notch1 Signaling Is Selectively Modulated by HPV16 E6 to Promote Squamous Cell Proliferation and Correlates with Cervical Cancer Prognosis , 2021, Cancer Research.

[26]  Qiang Liu,et al.  Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria. , 2021, Circulation research.

[27]  Lei Wang,et al.  Notch-Regulated Dendritic Cells Restrain Inflammation-Associated Colorectal Carcinogenesis , 2021, Cancer Immunology Research.

[28]  Weili Zhao,et al.  CREBBP/EP300 mutations promoted tumor progression in diffuse large B-cell lymphoma through altering tumor-associated macrophage polarization via FBXW7-NOTCH-CCL2/CSF1 axis , 2021, Signal Transduction and Targeted Therapy.

[29]  K. Konstantopoulos,et al.  A pro-carcinogenic colon microbe promotes breast tumorigenesis and metastatic progression and concomitantly activates Notch and βcatenin axes. , 2021, Cancer discovery.

[30]  G. Roti,et al.  Targeting oncogenic Notch signaling with SERCA inhibitors , 2021, Journal of Hematology & Oncology.

[31]  V. Marx.  Method of the Year: spatially resolved transcriptomics , 2021, Nature Methods.

[32]  R. Hendriks,et al.  Notch Signaling Promotes Disease Initiation and Progression in Murine Chronic Lymphocytic Leukemia. , 2020, Blood.

[33]  Yigong Shi,et al.  Structural basis of γ-secretase inhibition and modulation by small molecule drugs , 2020, Cell.

[34]  Darwin Chang,et al.  The landscape of driver mutations in cutaneous squamous cell carcinoma , 2020, bioRxiv.

[35]  M. Potente,et al.  Arterialization requires the timely suppression of cell growth , 2020, Nature.

[36]  J. Crabtree,et al.  Targeting Notch in oncology: the path forward , 2020, Nature Reviews Drug Discovery.

[37]  C. Rudin,et al.  Multi-omic analysis of lung tumors defines pathways activated in neuroendocrine transformation , 2020, bioRxiv.

[38]  W. Longabaugh,et al.  Systematic comparison of sea urchin and sea star developmental gene regulatory networks explains how novelty is incorporated in early development , 2020, Nature Communications.

[39]  P. A. Futreal,et al.  Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets , 2020, Clinical Cancer Research.

[40]  P. Chevallier,et al.  Phase 1 study to evaluate Crenigacestat (LY3039478) in combination with dexamethasone in patients with T‐cell acute lymphoblastic leukemia and lymphoma , 2020, Cancer.

[41]  Mary E. Ziegler,et al.  Slug regulates the Dll4-Notch-VEGFR2 axis to control endothelial cell activation and angiogenesis , 2020, Nature Communications.

[42]  Z. Biyasheva,et al.  Notch signaling defects in NK cells in patients with cancer , 2020, Cancer Immunology, Immunotherapy.

[43]  R. Schwabe,et al.  Maladaptive regeneration — the reawakening of developmental pathways in NASH and fibrosis , 2020, Nature Reviews Gastroenterology & Hepatology.

[44]  R. Schwabe,et al.  Notch activity characterizes a common hepatocellular carcinoma subtype with unique molecular and clinicopathologic features. , 2020, Journal of hepatology.

[45]  T. Mikkelsen,et al.  A Phase II and Pharmacodynamic Trial of RO4929097 for Patients With Recurrent/Progressive Glioblastoma. , 2020, Neurosurgery.

[46]  V. Lefebvre,et al.  Sox9 deletion causes severe intervertebral disc degeneration characterized by apoptosis, matrix remodeling, and compartment-specific transcriptomic changes. , 2020, Matrix biology : journal of the International Society for Matrix Biology.

[47]  V. Taylor,et al.  Oncogenic and Tumor-Suppressive Functions of NOTCH Signaling in Glioma , 2020, Cells.

[48]  H. Hammad,et al.  Wnt and Hippo pathways in regulatory T cells: a NOTCH above in asthma , 2020, Nature Immunology.

[49]  G. Berry,et al.  NOTCH-induced rerouting of endosomal trafficking disables regulatory T-cells in vasculitis. , 2020, The Journal of clinical investigation.

[50]  J. Soria,et al.  Phase 1 study of 2 high dose intensity schedules of the pan-Notch inhibitor crenigacestat (LY3039478) in combination with prednisone in patients with advanced or metastatic cancer , 2020, Investigational New Drugs.

[51]  Ming Li,et al.  Convergent lines of evidence support NOTCH4 as a schizophrenia risk gene , 2020, Journal of Medical Genetics.

[52]  E. Aikawa,et al.  Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling , 2020, Science Advances.

[53]  K. Nadeau,et al.  A Notch3-Marked Subpopulation of Vascular Smooth Muscle Cells Is the Cell of Origin for Occlusive Pulmonary Vascular Lesions , 2020, Circulation.

[54]  Congjian Xu,et al.  Tumour-associated neutrophils orchestrate intratumoural IL-8-driven immune evasion through Jagged2 activation in ovarian cancer , 2020, British Journal of Cancer.

[55]  R. Geha,et al.  A regulatory T cell Notch4-GDF15 axis licenses tissue inflammation in asthma , 2020, Nature Immunology.

[56]  M. Simon,et al.  The tumor microenvironment , 2020, Current Biology.

[57]  J. Frisén,et al.  A Widespread Neurogenic Potential of Neocortical Astrocytes Is Induced by Injury , 2020, Cell stem cell.

[58]  J. Chiang,et al.  Jagged2 progressively increased expression from Stage I to III of Bladder Cancer and Melatonin-mediated downregulation of Notch/Jagged2 suppresses the Bladder Tumorigenesis via inhibiting PI3K/AKT/mTOR/MMPs signaling , 2020, International journal of biological sciences.

[59]  Matthew S. Walters,et al.  Cigarette Smoke Activates NOTCH3 to Promote Goblet Cell Differentiation in Human Airway Epithelial Cells , 2020, bioRxiv.

[60]  J. Aster,et al.  Pharmacological disruption of the Notch transcription factor complex , 2020, Proceedings of the National Academy of Sciences.

[61]  Y. Chong,et al.  Increased Expression of Fibulin-1 Is Associated With Hepatocellular Carcinoma Progression by Regulating the Notch Signaling Pathway , 2020, Frontiers in Cell and Developmental Biology.

[62]  E. Canalis,et al.  Notch and the regulation of osteoclast differentiation and function. , 2020, Bone.

[63]  C. Moltrasio,et al.  Pleiotropic Role of Notch Signaling in Human Skin Diseases , 2020, International journal of molecular sciences.

[64]  C. Damodaran,et al.  A Review on Notch Signaling and Colorectal Cancer , 2020, Cells.

[65]  C. Rudin,et al.  SC-002 in patients with relapsed or refractory small cell lung cancer and large cell neuroendocrine carcinoma: Phase 1 study. , 2020, Lung cancer.

[66]  J. Savage,et al.  Evolution of Human Brain Size-Associated NOTCH2NL Genes Proceeds toward Reduced Protein Levels , 2020, Molecular biology and evolution.

[67]  K. Stegmaier,et al.  Blockade of Oncogenic NOTCH1 with the SERCA Inhibitor CAD204520 in T Cell Acute Lymphoblastic Leukemia. , 2020, Cell chemical biology.

[68]  Marjolein J. W. de Bruijn,et al.  Notch signaling licenses allergic airway inflammation by promoting Th2 cell lymph node egress. , 2020, The Journal of clinical investigation.

[69]  Long Guo,et al.  Recapitulating the human segmentation clock with pluripotent stem cells , 2020, Nature.

[70]  Barry S Taylor,et al.  Toward a More Precise Future for Oncology. , 2020, Cancer cell.

[71]  Kari A. Huppert,et al.  Sox9 Is a Modifier of the Liver Disease Severity in a Mouse Model of Alagille Syndrome , 2020, Hepatology.

[72]  Kefei Yuan,et al.  NCSTN promotes hepatocellular carcinoma cell growth and metastasis via β-catenin activation in a Notch1/AKT dependent manner , 2020, Journal of Experimental & Clinical Cancer Research.

[73]  J. Wands,et al.  Prometastatic Secretome Trafficking via Exosomes Initiates Pancreatic Cancer Pulmonary Metastasis. , 2020, Cancer letters.

[74]  Zhimin Lu,et al.  Reduction of myeloid derived suppressor cells by inhibiting Notch pathway prevents the progression of endometriosis in mice model. , 2020, International immunopharmacology.

[75]  R. Eils,et al.  NOTCH target gene HES5 mediates oncogenic and tumor suppressive functions in hepatocarcinogenesis , 2020, Oncogene.

[76]  Akiyoshi Uemura,et al.  Dll4 Suppresses Transcytosis for Arterial Blood-Retinal Barrier Homeostasis , 2020, Circulation research.

[77]  Howard Y. Chang,et al.  Long non-coding RNA HOTAIR drives EZH2-dependent myofibroblast activation in systemic sclerosis through miRNA 34a-dependent activation of NOTCH , 2020, Annals of the rheumatic diseases.

[78]  Phase 0 Trial , 2020, Definitions.

[79]  Gerhard K. H. Przemeck,et al.  DLL1- and DLL4-Mediated Notch Signaling Is Essential for Adult Pancreatic Islet Homeostasis , 2020, Diabetes.

[80]  R. Burger,et al.  Demcizumab combined with paclitaxel for platinum-resistant ovarian, primary peritoneal, and fallopian tube cancer: The SIERRA open-label phase Ib trial. , 2020, Gynecologic oncology.

[81]  M. C. Jørgensen,et al.  Jag1 Modulates an Oscillatory Dll1-Notch-Hes1 Signaling Module to Coordinate Growth and Fate of Pancreatic Progenitors. , 2020, Developmental cell.

[82]  Daxin Wang,et al.  Letter by Wang et al Regarding Article, "Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regulatory T Cell-Dependent Mechanisms". , 2020, Circulation.

[83]  A. Vincent-Salomon,et al.  Cancer-associated fibroblast heterogeneity in axillary lymph nodes drives metastases in breast cancer through complementary mechanisms , 2020, Nature Communications.

[84]  M. Grever,et al.  A phase I study of an oral selective gamma secretase (GS) inhibitor RO4929097 in combination with neoadjuvant paclitaxel and carboplatin in triple negative breast cancer , 2020, Investigational New Drugs.

[85]  A. Miyawaki,et al.  Coupling delay controls synchronized oscillation in the segmentation clock , 2020, Nature.

[86]  A. Joutel.  Prospects for Diminishing the Impact of Nonamyloid Small-Vessel Diseases of the Brain. , 2020, Annual review of pharmacology and toxicology.

[87]  K. Claeys,et al.  POGLUT1 biallelic mutations cause myopathy with reduced satellite cells, α-dystroglycan hypoglycosylation and a distinctive radiological pattern , 2020, Acta Neuropathologica.

[88]  María Méndez-Lago,et al.  Signalling codes for the maintenance and lineage commitment of embryonic gastric epithelial progenitors. , 2020, Development.

[89]  D. Nikolov,et al.  ADAM proteases: Emerging role and targeting of the non-catalytic domains. , 2019, Cancer letters.

[90]  R. Touyz,et al.  Notch3 signalling and vascular remodelling in pulmonary arterial hypertension , 2019, Clinical science.

[91]  T. Gabaldón,et al.  Gene gain and loss across the Metazoa Tree of Life , 2019, Nature Ecology & Evolution.

[92]  P. Grabham,et al.  High-Dose Radiation Increases Notch1 in Tumor Vasculature , 2019, International journal of radiation oncology, biology, physics.

[93]  M. Hung,et al.  ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis , 2019, Molecular Cancer.

[94]  L. Di Marcotullio,et al.  Kras/ADAM17-dependent Jag1-ICD reverse signalling sustains colorectal cancer progression and chemoresistance. , 2019, Cancer research.

[95]  A. Balmain,et al.  Niche-Specific Factors Dynamically Regulate Sebaceous Gland Stem Cells in the Skin. , 2019, Developmental cell.

[96]  Jianru Wang,et al.  JAG2/Notch2 inhibits intervertebral disc degeneration by modulating cell proliferation, apoptosis, and extracellular matrix , 2019, Arthritis Research & Therapy.

[97]  R. Moreno,et al.  Phosphorylation-dependent regulation of the NOTCH1 intracellular domain by dual-specificity tyrosine-regulated kinase 2 , 2019, Cellular and Molecular Life Sciences.

[98]  M. Krasnow,et al.  Rare Pulmonary Neuroendocrine Cells Are Stem Cells Regulated by Rb, p53, and Notch , 2019, Cell.

[99]  D. Wei,et al.  Gamma‐secretase complex‐dependent intramembrane proteolysis of CD147 regulates the Notch1 signaling pathway in hepatocellular carcinoma , 2019, The Journal of pathology.

[100]  Qingchun Zhao,et al.  Novel ADAM-17 inhibitor ZLDI-8 inhibits the proliferation and metastasis of chemo-resistant non-small-cell lung cancer by reversing Notch and epithelial mesenchymal transition in vitro and in vivo. , 2019, Pharmacological research.

[101]  R. Salgia,et al.  Notch Signaling in Breast Cancer: From Pathway Analysis to Therapy. , 2019, Cancer letters.

[102]  Yinying Lu,et al.  MicroRNA-3163 targets ADAM-17 and enhances the sensitivity of hepatocellular carcinoma cells to molecular targeted agents , 2019, Cell Death & Disease.

[103]  J. Zúñiga-Pflücker,et al.  RBPJ-dependent Notch signaling initiates the T cell program in a subset of thymus-seeding progenitors , 2019, Nature Immunology.

[104]  D. Adams,et al.  Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis , 2019, Cancer cell.

[105]  J. Ruland.  Colon Cancer: Epithelial Notch Signaling Recruits Neutrophils to Drive Metastasis. , 2019, Cancer cell.

[106]  C. Rudin,et al.  Efficacy and Safety of Rovalpituzumab Tesirine in Third-Line and Beyond Patients with DLL3-Expressing, Relapsed/Refractory Small-Cell Lung Cancer: Results From the Phase II TRINITY Study , 2019, Clinical Cancer Research.

[107]  Lei-bo Xu,et al.  An essential role of RNF187 in Notch1 mediated metastasis of hepatocellular carcinoma , 2019, Journal of Experimental & Clinical Cancer Research.

[108]  A. Mansfield,et al.  Expression of delta-like protein 3 is reproducibly present in a subset of small cell lung carcinomas and pulmonary carcinoid tumors. , 2019, Lung cancer.

[109]  Soumitra S Ghosh,et al.  CSL controls telomere maintenance and genome stability in human dermal fibroblasts , 2019, Nature Communications.

[110]  Kongming Wu,et al.  Next generation chimeric antigen receptor T cells: safety strategies to overcome toxicity , 2019, Molecular Cancer.

[111]  ChangHwan Lee,et al.  Dynamics of Notch-Dependent Transcriptional Bursting in its Native Context , 2018, bioRxiv.

[112]  K. Dou,et al.  Notch signaling via Wnt regulates the proliferation of alternative, CCR2-independent tumor-associated macrophages in hepatocellular carcinoma. , 2019, Cancer research.

[113]  A. Harris,et al.  Development of Therapeutic Anti-JAGGED1 Antibodies for Cancer Therapy , 2019, Molecular Cancer Therapeutics.

[114]  Xuejun Yang,et al.  Notch1 signaling pathway promotes invasion, self-renewal and growth of glioma initiating cells via modulating chemokine system CXCL12/CXCR4 , 2019, Journal of experimental & clinical cancer research : CR.

[115]  X. Shang,et al.  Notch Signaling in Osteogenesis, Osteoclastogenesis, and Angiogenesis. , 2019, The American journal of pathology.

[116]  R. Fiorotto,et al.  Pathobiology of inherited biliary diseases: a roadmap to understand acquired liver diseases , 2019, Nature Reviews Gastroenterology & Hepatology.

[117]  A. Bullock,et al.  A randomized phase II trial of nab‐paclitaxel and gemcitabine with tarextumab or placebo in patients with untreated metastatic pancreatic cancer , 2019, Cancer medicine.

[118]  L. Shevde,et al.  The Tumor Microenvironment Innately Modulates Cancer Progression. , 2019, Cancer research.

[119]  J. Cashman,et al.  Disruption of NOTCH signaling by a small molecule inhibitor of the transcription factor RBPJ , 2019, Scientific Reports.

[120]  Jiuhong Kang,et al.  MicroRNA-153 improves the neurogenesis of neural stem cells and enhances the cognitive ability of aged mice through the notch signaling pathway , 2019, Cell Death & Differentiation.

[121]  B. Chiang,et al.  Multi-Faceted Notch in Allergic Airway Inflammation , 2019, International journal of molecular sciences.

[122]  D. Carbone,et al.  DLL3: an emerging target in small cell lung cancer , 2019, Journal of Hematology & Oncology.

[123]  Y. Zhang,et al.  Comprehensive genomic profiling of small cell lung cancer in Chinese patients and the implications for therapeutic potential , 2019, Cancer medicine.

[124]  B. de Strooper,et al.  Safe targeting of T cell acute lymphoblastic leukemia by pathology-specific NOTCH inhibition , 2019, Science Translational Medicine.

[125]  Howard H. Yang,et al.  The transcription factor CBFB suppresses breast cancer through orchestrating translation and transcription , 2019, Nature Communications.

[126]  S. Verleden,et al.  The Notch ligand DNER regulates macrophage IFNγ release in chronic obstructive pulmonary disease , 2019, EBioMedicine.

[127]  R. Muschel,et al.  Tumour-Derived Laminin α5 (LAMA5) Promotes Colorectal Liver Metastasis Growth, Branching Angiogenesis and Notch Pathway Inhibition , 2019, Cancers.

[128]  D. Sprinzak,et al.  Notch-Mediated Tumor-Stroma-Inflammation Networks Promote Invasive Properties and CXCL8 Expression in Triple-Negative Breast Cancer , 2019, Front. Immunol..

[129]  Markus Rempfler,et al.  Self-organization and symmetry breaking in intestinal organoid development , 2019, Nature.

[130]  Zhao-Jun Liu,et al.  Intracellular Notch1 Signaling in Cancer‐Associated Fibroblasts Dictates the Plasticity and Stemness of Melanoma Stem/Initiating Cells , 2019, Stem cells.

[131]  Jason V. Evans,et al.  Determinant roles of dendritic cell-expressed Notch Delta-like and Jagged ligands on anti-tumor T cell immunity , 2019, Journal of Immunotherapy for Cancer.

[132]  P. Jia,et al.  PMN-MDSCs Enhance CTC Metastatic Properties through Reciprocal Interactions via ROS/Notch/Nodal Signaling , 2019, International journal of molecular sciences.

[133]  R. Lake,et al.  HDAC1 negatively regulates selective mitotic chromatin binding of the Notch effector RBPJ in a KDM5A-dependent manner , 2019, Nucleic acids research.

[134]  S. Bray,et al.  SWI/SNF chromatin remodeling controls Notch‐responsive enhancer accessibility , 2019, EMBO reports.

[135]  O. Elemento,et al.  Delta-like protein 3 expression and therapeutic targeting in neuroendocrine prostate cancer , 2019, Science Translational Medicine.

[136]  R. Baffa,et al.  A phase I, dose-escalation study of PF-06650808, an anti-Notch3 antibody–drug conjugate, in patients with breast cancer and other advanced solid tumors , 2019, Investigational New Drugs.

[137]  N. Batada,et al.  Wnt and Notch signaling govern self-renewal and differentiation in a subset of human glioblastoma stem cells , 2019, Genes & development.

[138]  P. Karmakar,et al.  A novel triazole, NMK-T-057, induces autophagic cell death in breast cancer cells by inhibiting γ-secretase–mediated activation of Notch signaling , 2019, The Journal of Biological Chemistry.

[139]  M. Fukayama,et al.  BHLHA15-Positive Secretory Precursor Cells Can Give Rise to Tumors in Intestine and Colon in Mice. , 2019, Gastroenterology.

[140]  J. Bergh,et al.  Impact of Epithelial-Stromal Interactions on Peritumoral Fibroblasts in Ductal Carcinoma in Situ. , 2019, Journal of the National Cancer Institute.

[141]  J. Qu,et al.  Modeling CADASIL vascular pathologies with patient-derived induced pluripotent stem cells , 2019, Protein & Cell.

[142]  Yigong Shi,et al.  Recognition of the amyloid precursor protein by human γ-secretase , 2019, Science.

[143]  Kong-Peng Lam,et al.  BCR-dependent lineage plasticity in mature B cells , 2019, Science.

[144]  S. Romeo.  Notch and Nonalcoholic Fatty Liver and Fibrosis , 2019, The New England journal of medicine.

[145]  Fokhrul Hossain,et al.  Adenosine A2A Receptor Stimulation Inhibits TCR-Induced Notch1 Activation in CD8+T-Cells , 2019, Front. Immunol..

[146]  K. Coombes,et al.  Co‐Expression Analysis Reveals Mechanisms Underlying the Varied Roles of NOTCH1 in NSCLC , 2019, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

[147]  M. Kool,et al.  Increased surface expression of NOTCH on memory T cells in peripheral blood from patients with asthma. , 2019, The Journal of allergy and clinical immunology.

[148]  Shawn C. Little,et al.  Oncogenic Notch promotes long-range regulatory interactions within hyperconnected 3D cliques , 2019, bioRxiv.

[149]  Angelo S. Mao,et al.  An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation , 2019, Nature Biotechnology.

[150]  Yigong Shi,et al.  Structural basis of Notch recognition by human γ-secretase , 2018, Nature.

[151]  David C. Smith,et al.  A phase 1 dose escalation and expansion study of Tarextumab (OMP-59R5) in patients with solid tumors , 2018, Investigational new drugs.

[152]  X. Bian,et al.  Invasion of white matter tracts by glioma stem cells is regulated by a NOTCH1–SOX2 positive-feedback loop , 2018, Nature Neuroscience.

[153]  J. Crabtree,et al.  Notch Signaling Regulates Mitochondrial Metabolism and NF-κB Activity in Triple-Negative Breast Cancer Cells via IKKα-Dependent Non-canonical Pathways , 2018, Front. Oncol..

[154]  K. Kaun,et al.  Alcohol Activates Scabrous-Notch to Influence Associated Memories , 2018, Neuron.

[155]  A. Groisman,et al.  Blood flow-induced Notch activation and endothelial migration enable vascular remodeling in zebrafish embryos , 2018, Nature Communications.

[156]  R. Schwabe,et al.  Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis , 2018, Science Translational Medicine.

[157]  Minhong Yan,et al.  Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice. , 2018, Blood.

[158]  P. Liu,et al.  NUMB maintains bone mass by promoting degradation of PTEN and GLI1 via ubiquitination in osteoblasts , 2018, Bone Research.

[159]  H. Wakimoto,et al.  Cell Surface Notch Ligand DLL3 is a Therapeutic Target in Isocitrate Dehydrogenase–mutant Glioma , 2018, Clinical Cancer Research.

[160]  Jonathan Touboul,et al.  In vitro characterization of the human segmentation clock , 2018, bioRxiv.

[161]  R. Andriantsitohaina,et al.  Glycosylation as new pharmacological strategies for diseases associated with excessive angiogenesis , 2018, Pharmacology & therapeutics.

[162]  O. Mir,et al.  Notch pathway inhibition with LY3039478 in soft tissue sarcoma and gastrointestinal stromal tumours. , 2018, European journal of cancer.

[163]  L. Sussel,et al.  Notch signaling dynamically regulates adult &bgr; cell proliferation and maturity , 2018, The Journal of clinical investigation.

[164]  P. Mehlen,et al.  Notch Signaling in the Tumor Microenvironment. , 2018, Cancer cell.

[165]  C. Blobel,et al.  Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds. , 2018, Physiological reviews.

[166]  M. Guilliams,et al.  'NOTCHing up' the In Vitro Production of Dendritic Cells. , 2018, Trends in immunology.

[167]  P. Lehner,et al.  Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia , 2018, Nature Communications.

[168]  H. Hammad,et al.  The emerging role of ADAM metalloproteinases in immunity , 2018, Nature Reviews Immunology.

[169]  David C. Smith,et al.  A first-in-human phase 1a study of the bispecific anti-DLL4/anti-VEGF antibody navicixizumab (OMP-305B83) in patients with previously treated solid tumors , 2018, Investigational New Drugs.

[170]  J. Sul,et al.  Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis , 2018, Theranostics.

[171]  R. Lories,et al.  A Notch in the joint that exacerbates osteoarthritis , 2018, Nature Reviews Rheumatology.

[172]  E. Tartour,et al.  Resident memory T cells, critical components in tumor immunology , 2018, Journal of Immunotherapy for Cancer.

[173]  Yisheng Wang,et al.  Notch ligand Jagged1 promotes mesenchymal stromal cell-based cartilage repair , 2018, Experimental & Molecular Medicine.

[174]  S. Piana,et al.  The bHLH transcription factor DEC1 promotes thyroid cancer aggressiveness by the interplay with NOTCH1 , 2018, Cell Death & Disease.

[175]  P. Maity,et al.  JunB defines functional and structural integrity of the epidermo-pilosebaceous unit in the skin , 2018, Nature Communications.

[176]  Sharon R. Pine.  Rethinking Gamma-secretase Inhibitors for Treatment of Non–small-Cell Lung Cancer: Is Notch the Target? , 2018, Clinical Cancer Research.

[177]  S. Santarone,et al.  NOTCH and Graft-Versus-Host Disease , 2018, Front. Immunol..

[178]  Chien‐Hung Yeh,et al.  FBXW7: a critical tumor suppressor of human cancers , 2018, Molecular Cancer.

[179]  A. Villani,et al.  Large-Scale Human Dendritic Cell Differentiation Revealing Notch-Dependent Lineage Bifurcation and Heterogeneity , 2018, Cell reports.

[180]  J. Dittmer.  Breast cancer stem cells: Features, key drivers and treatment options. , 2018, Seminars in cancer biology.

[181]  J. Heymach,et al.  A phase I dose-escalation and dose-expansion study of brontictuzumab in subjects with selected solid tumors , 2018, Annals of oncology : official journal of the European Society for Medical Oncology.

[182]  J. L. de la Pompa,et al.  Bmp2 and Notch cooperate to pattern the embryonic endocardium , 2018, Development.

[183]  Xiaojun Wu,et al.  Alterations of Notch pathway in patients with adenoid cystic carcinoma of the trachea and its impact on survival. , 2018, Lung cancer.

[184]  B. Ke,et al.  Serelaxin induces Notch1 signaling and alleviates hepatocellular damage in orthotopic liver transplantation , 2018, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

[185]  Camino de Juan Romero,et al.  Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels , 2018, Cell.

[186]  P. Meltzer,et al.  Targeting Notch1 and IKKα Enhanced NF-κB Activation in CD133+ Skin Cancer Stem Cells , 2018, Molecular Cancer Therapeutics.

[187]  Chengzhong Ye,et al.  Single-cell profiling of breast cancer T cells reveals a tissue-resident memory subset associated with improved prognosis , 2018, Nature Medicine.

[188]  C. Rankin,et al.  A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling , 2018, Molecular Psychiatry.

[189]  A. Cumano,et al.  The Notch Signaling Pathway Is Balancing Type 1 Innate Lymphoid Cell Immune Functions , 2018, Front. Immunol..

[190]  M. Merad,et al.  Notch Signaling Facilitates In Vitro Generation of Cross-Presenting Classical Dendritic Cells , 2018, Cell reports.

[191]  G. Dotto,et al.  Notch-effector CSL promotes squamous cell carcinoma by repressing histone demethylase KDM6B , 2018, The Journal of clinical investigation.

[192]  J. Desai,et al.  A multi-arm phase I dose escalating study of an oral NOTCH inhibitor BMS-986115 in patients with advanced solid tumours , 2018, Investigational New Drugs.

[193]  L. Naumovski,et al.  ABT-165, a Dual Variable Domain Immunoglobulin (DVD-Ig) Targeting DLL4 and VEGF, Demonstrates Superior Efficacy and Favorable Safety Profiles in Preclinical Models , 2018, Molecular Cancer Therapeutics.

[194]  L. Mureşan,et al.  Activation of the Notch Signaling Pathway In Vivo Elicits Changes in CSL Nuclear Dynamics , 2018, Developmental cell.

[195]  Takaaki Ito.  Intratumoral heterogeneity of Notch1 expression in small cell lung cancer. , 2018, Journal of thoracic disease.

[196]  H. Jafar-Nejad,et al.  A New Model of Alagille Syndrome With Broad Phenotypic Representation. , 2018, Gastroenterology.

[197]  J. Califano,et al.  The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma , 2018, Journal of dental research.

[198]  Christoph A. Merten,et al.  Modulation of Phase Shift between Wnt and Notch Signaling Oscillations Controls Mesoderm Segmentation , 2018, Cell.

[199]  S. Julia,et al.  Diagnostic strategy in segmentation defect of the vertebrae: a retrospective study of 73 patients , 2018, Journal of Medical Genetics.

[200]  A. Kulshrestha,et al.  The curious case of vacuolar ATPase: regulation of signaling pathways , 2018, Molecular Cancer.

[201]  Lisa V. Hampson,et al.  A phase I trial of the γ-secretase inhibitor MK-0752 in combination with gemcitabine in patients with pancreatic ductal adenocarcinoma , 2018, British Journal of Cancer.

[202]  S. Winandy,et al.  Novel TCR-Mediated Mechanisms of Notch Activation and Signaling , 2018, The Journal of Immunology.

[203]  M. Hidalgo,et al.  Phase IB Trial of the Anti-Cancer Stem Cell DLL4-Binding Agent Demcizumab with Pemetrexed and Carboplatin as First-Line Treatment of Metastatic Non-Squamous NSCLC , 2018, Targeted Oncology.

[204]  Shijun Kang,et al.  Notch1 signaling in melanoma cells promoted tumor-induced immunosuppression via upregulation of TGF-β1 , 2018, Journal of experimental & clinical cancer research : CR.

[205]  Yu You,et al.  Antitumor activity of Notch-1 inhibition in human colorectal carcinoma cells , 2017, Oncology reports.

[206]  S. Blacklow,et al.  Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10 , 2017, Cell.

[207]  Yibin Kang,et al.  Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy. , 2017, Cancer cell.

[208]  Musaddique Hussain,et al.  Notch Signaling: Linking Embryonic Lung Development and Asthmatic Airway Remodeling , 2017, Molecular Pharmacology.

[209]  G. Struhl,et al.  Epsin-Dependent Ligand Endocytosis Activates Notch by Force , 2017, Cell.

[210]  A. Bass,et al.  Interplay between Notch1 and Notch3 promotes EMT and tumor initiation in squamous cell carcinoma , 2017, Nature Communications.

[211]  R. Sandberg,et al.  Mouse Model of Alagille Syndrome and Mechanisms of Jagged1 Missense Mutations , 2017, Gastroenterology.

[212]  Brian J. Archer,et al.  NOTCH1 is a mechanosensor in adult arteries , 2017, Nature Communications.

[213]  Wenyi Wei,et al.  NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis. , 2017, Molecular cell.

[214]  E. Chiocca,et al.  Development of a Function-Blocking Antibody Against Fibulin-3 as a Targeted Reagent for Glioblastoma , 2017, Clinical Cancer Research.

[215]  William J. Polacheck,et al.  A non-canonical Notch complex regulates adherens junctions and vascular barrier function , 2017, Nature.

[216]  J. Minna,et al.  Small-cell lung cancer: what we know, what we need to know and the path forward , 2017, Nature Reviews Cancer.

[217]  K. Owzar,et al.  An aberrant NOTCH2-BCR signaling axis in B cells from patients with chronic GVHD. , 2017, Blood.

[218]  P. Ma,et al.  Nothing But NET: A Review of Neuroendocrine Tumors and Carcinomas , 2017, Neoplasia.

[219]  S. Rafii,et al.  Endothelial jagged-2 sustains hematopoietic stem and progenitor reconstitution after myelosuppression , 2017, The Journal of clinical investigation.

[220]  L. Mahadevan,et al.  Excitable Dynamics and Yap-Dependent Mechanical Cues Drive the Segmentation Clock , 2017, Cell.

[221]  B. Osborne,et al.  Anti-Jagged Immunotherapy Inhibits MDSCs and Overcomes Tumor-Induced Tolerance. , 2017, Cancer research.

[222]  U. Lendahl,et al.  Notch Signaling in Development, Tissue Homeostasis, and Disease. , 2017, Physiological reviews.

[223]  Marjolein J. W. de Bruijn,et al.  Notch signaling in T cells is essential for allergic airway inflammation, but expression of the Notch ligands Jagged 1 and Jagged 2 on dendritic cells is dispensable , 2017, The Journal of allergy and clinical immunology.

[224]  Michael N. Wosczyna,et al.  Macrophage-released ADAMTS1 promotes muscle stem cell activation , 2017, Nature Communications.

[225]  Yihai Cao,et al.  MicroRNA-26a and -26b inhibit lens fibrosis and cataract by negatively regulating Jagged-1/Notch signaling pathway , 2017, Cell Death and Differentiation.

[226]  K. Alitalo,et al.  Uncontrolled angiogenic precursor expansion causes coronary artery anomalies in mice lacking Pofut1 , 2017, Nature Communications.

[227]  J. Zhen,et al.  Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling , 2017, Nature Communications.

[228]  H. Berman,et al.  Notch Shapes the Innate Immunophenotype in Breast Cancer. , 2017, Cancer discovery.

[229]  Z. Ji,et al.  Numb−/low Enriches a Castration-Resistant Prostate Cancer Cell Subpopulation Associated with Enhanced Notch and Hedgehog Signaling , 2017, Clinical Cancer Research.

[230]  Zhipeng Wang,et al.  Jagged1 promotes aromatase inhibitor resistance by modulating tumor-associated macrophage differentiation in breast cancer patients , 2017, Breast Cancer Research and Treatment.

[231]  Pierre Saintigny,et al.  Non-canonical NOTCH3 signalling limits tumour angiogenesis , 2017, Nature Communications.

[232]  R. Adams,et al.  Dll4 and Notch signalling couples sprouting angiogenesis and artery formation , 2017, Nature Cell Biology.

[233]  B. Nabet,et al.  Exosome RNA Unshielding Couples Stromal Activation to Pattern Recognition Receptor Signaling in Cancer , 2017, Cell.

[234]  Katarzyna Siudeja,et al.  Intrinsic regulation of enteroendocrine fate by Numb , 2017, The EMBO journal.

[235]  Xiaoju Liu,et al.  Effects of PM2.5 exposure on the Notch signaling pathway and immune imbalance in chronic obstructive pulmonary disease. , 2017, Environmental pollution.

[236]  Arndt F. Siekmann,et al.  Endothelial Notch signalling limits angiogenesis via control of artery formation , 2017, Nature Cell Biology.

[237]  A. Oza,et al.  Phase II study of cabozantinib (cabo) in patients (pts) with recurrent/metastatic endometrial cancer (EC): A study of the Princess Margaret, Chicago, and California phase II consortia. , 2017 .

[238]  C. Rudin,et al.  Unravelling the biology of SCLC: implications for therapy , 2017, Nature Reviews Clinical Oncology.

[239]  D. Sprinzak,et al.  The Canonical Notch Signaling Pathway: Structural and Biochemical Insights into Shape, Sugar, and Force. , 2017, Developmental cell.

[240]  P. Zandstra,et al.  Progenitor T-cell differentiation from hematopoietic stem cells using Delta-like-4 and VCAM-1 , 2017, Nature Methods.

[241]  Thomas Vierbuchen,et al.  Myt1l safeguards neuronal identity by actively repressing many non-neuronal fates , 2017, Nature.

[242]  D. Amsen.  T cells take directions from supporting cast in graft-versus-host disease. , 2017, The Journal of clinical investigation.

[243]  C. Sanders,et al.  Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains , 2017, Science Advances.

[244]  Hongbing Shen,et al.  Exome-Wide Association Study Identified New Risk Loci for Hirschsprung’s Disease , 2016, Molecular Neurobiology.

[245]  P. Meltzer,et al.  Clinical Activity of the γ-Secretase Inhibitor PF-03084014 in Adults With Desmoid Tumors (Aggressive Fibromatosis). , 2017, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[246]  M. Götte,et al.  Syndecan-1 is a novel molecular marker for triple negative inflammatory breast cancer and modulates the cancer stem cell phenotype via the IL-6/STAT3, Notch and EGFR signaling pathways , 2017, Molecular Cancer.

[247]  P. Vaupel,et al.  Hypofractionated re-irradiation of large-sized recurrent breast cancer with thermography-controlled, contact-free water-filtered infra-red-A hyperthermia: a retrospective study of 73 patients , 2017, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[248]  L. Samuelson,et al.  Notch as a Driver of Gastric Epithelial Cell Proliferation , 2017, Cellular and molecular gastroenterology and hepatology.

[249]  F. Radtke,et al.  Notch as a tumour suppressor , 2017, Nature Reviews Cancer.

[250]  V. Lefebvre,et al.  Transcriptional control of chondrocyte specification and differentiation. , 2017, Seminars in cell & developmental biology.

[251]  J. Aster,et al.  The Varied Roles of Notch in Cancer. , 2017, Annual review of pathology.

[252]  B. Kowtharapu,et al.  MiR-182 promotes cancer invasion by linking RET oncogene activated NF-κB to loss of the HES1/Notch1 regulatory circuit , 2017, Molecular Cancer.

[253]  P. Handford,et al.  Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands , 2017, bioRxiv.

[254]  Yaohui Nie,et al.  Pten is necessary for the quiescence and maintenance of adult muscle stem cells , 2017, Nature Communications.

[255]  A. Sarin,et al.  The NOTCH1-autophagy interaction: Regulating self-eating for survival , 2017, Autophagy.

[256]  Y. Totoki,et al.  Targeting the Notch-regulated non-coding RNA TUG1 for glioma treatment , 2016, Nature Communications.

[257]  A. Ferrando,et al.  Leukemia-specific delivery of mutant NOTCH1 targeted therapy , 2018, The Journal of experimental medicine.

[258]  Linzhao Cheng,et al.  Human NOTCH4 is a key target of RUNX1 in megakaryocytic differentiation. , 2016, Blood.

[259]  J. Soria,et al.  First-in-human study of LY3039478, an oral Notch signaling inhibitor in advanced or metastatic cancer , 2016, Annals of oncology : official journal of the European Society for Medical Oncology.

[260]  K. Pradhan,et al.  Notch Pathway Is Activated via Genetic and Epigenetic Alterations and Is a Therapeutic Target in Clear Cell Renal Cancer* , 2016, The Journal of Biological Chemistry.

[261]  Jing Wang,et al.  Activating NOTCH1 Mutations Define a Distinct Subgroup of Patients With Adenoid Cystic Carcinoma Who Have Poor Prognosis, Propensity to Bone and Liver Metastasis, and Potential Responsiveness to Notch1 Inhibitors , 2016, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[262]  Peijun Liu,et al.  The blockage of Notch signalling promoted the generation of polymorphonuclear myeloid-derived suppressor cells with lower immunosuppression. , 2016, European journal of cancer.

[263]  H. Clevers,et al.  Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells , 2016, Nature Immunology.

[264]  ChangHwan Lee,et al.  C. elegans GLP-1/Notch activates transcription in a probability gradient across the germline stem cell pool , 2016, eLife.

[265]  S. Markowitz,et al.  Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. , 2016, Gastroenterology.

[266]  S. Bray.  Notch signalling in context , 2016, Nature Reviews Molecular Cell Biology.

[267]  Luc Girard,et al.  ASCL1 and NEUROD1 Reveal Heterogeneity in Pulmonary Neuroendocrine Tumors and Regulate Distinct Genetic Programs. , 2016, Cell reports.

[268]  Sridhar Ramaswamy,et al.  HER2 expression identifies dynamic functional states within circulating breast cancer cells , 2016, Nature.

[269]  W. Seeger,et al.  Notch1 signalling regulates endothelial proliferation and apoptosis in pulmonary arterial hypertension , 2016, European Respiratory Journal.

[270]  H. Soares,et al.  The γ-Secretase Modulator, BMS-932481, Modulates Aβ Peptides in the Plasma and Cerebrospinal Fluid of Healthy Volunteers , 2016, The Journal of Pharmacology and Experimental Therapeutics.

[271]  P. Tsao,et al.  Epithelial Notch signaling regulates lung alveolar morphogenesis and airway epithelial integrity , 2016, Proceedings of the National Academy of Sciences.

[272]  M. Ittmann,et al.  Jagged1 upregulation in prostate epithelial cells promotes formation of reactive stroma in the Pten null mouse model for prostate cancer , 2016, Oncogene.

[273]  Pedro E. M. Lopes,et al.  The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. , 2016, Cancer research.

[274]  A. Chang,et al.  Myeloid-Derived Suppressor Cells Endow Stem-like Qualities to Breast Cancer Cells through IL6/STAT3 and NO/NOTCH Cross-talk Signaling. , 2016, Cancer research.

[275]  D. Edwards,et al.  Oncogenic mTOR signaling recruits myeloid-derived suppressor cells to promote tumor initiation , 2016, Nature Cell Biology.

[276]  K. Peck,et al.  Molecular and Clinical Effects of Notch Inhibition in Glioma Patients: A Phase 0/I Trial , 2016, Clinical Cancer Research.

[277]  J. Redondo,et al.  Sequential Ligand-Dependent Notch Signaling Activation Regulates Valve Primordium Formation and Morphogenesis. , 2016, Circulation research.

[278]  F. Huang,et al.  Forced Activation of Notch in Macrophages Represses Tumor Growth by Upregulating miR-125a and Disabling Tumor-Associated Macrophages. , 2016, Cancer research.

[279]  A. Fields,et al.  Protein Kinase Cι Drives a NOTCH3-dependent Stem-like Phenotype in Mutant KRAS Lung Adenocarcinoma. , 2016, Cancer cell.

[280]  P. Lemotte,et al.  Characterization of activating mutations of NOTCH3 in T cell acute lymphoblastic leukemia and anti-leukemic activity of NOTCH3 inhibitory antibodies , 2016, Oncogene.

[281]  N. Socci,et al.  Next-Generation Sequencing of Pulmonary Large Cell Neuroendocrine Carcinoma Reveals Small Cell Carcinoma–like and Non–Small Cell Carcinoma–like Subsets , 2016, Clinical Cancer Research.

[282]  Zhiguo Chen,et al.  MMGZ01, an anti-DLL4 monoclonal antibody, promotes nonfunctional vessels and inhibits breast tumor growth. , 2016, Cancer letters.

[283]  Suzanne F. Jones,et al.  A first-in-human phase I study of the oral Notch inhibitor, LY900009, in patients with advanced cancer. , 2016, European journal of cancer.

[284]  A. Louvi,et al.  Notch1 and Notch2 receptors regulate mouse and human gastric antral epithelial cell homoeostasis , 2016, Gut.

[285]  R. Gibbs,et al.  Genomic analyses identify molecular subtypes of pancreatic cancer , 2016, Nature.

[286]  A. Cumano,et al.  Single-Cell Gene Expression Analyses Reveal Heterogeneous Responsiveness of Fetal Innate Lymphoid Progenitors to Notch Signaling. , 2016, Cell reports.

[287]  L. Ivashkiv,et al.  RBP-J is required for M2 macrophage polarization in response to chitin and mediates expression of a subset of M2 genes , 2016, Protein & Cell.

[288]  Kole T. Roybal,et al.  Precision Tumor Recognition by T Cells With Combinatorial Antigen-Sensing Circuits , 2016, Cell.

[289]  Sarah A. King,et al.  A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. , 2016, Cell stem cell.

[290]  S. Rafii,et al.  Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis , 2016, Nature Medicine.

[291]  Shawn M. Gillespie,et al.  An oncogenic MYB feedback loop drives alternate cell fates in adenoid cystic carcinoma , 2016, Nature Genetics.

[292]  J. L. de la Pompa,et al.  Endocardial Notch Signaling in Cardiac Development and Disease. , 2016, Circulation research.

[293]  L. Mariani,et al.  A Tumor Suppressor Function for Notch Signaling in Forebrain Tumor Subtypes. , 2015, Cancer cell.

[294]  Shiying Yu,et al.  Notch signaling: an emerging therapeutic target for cancer treatment. , 2015, Cancer letters.

[295]  Jamie L. Marshall,et al.  Jagged 1 Rescues the Duchenne Muscular Dystrophy Phenotype , 2015, Cell.

[296]  K. Hankenson,et al.  Extracellular signaling molecules to promote fracture healing and bone regeneration. , 2015, Advanced drug delivery reviews.

[297]  O. Sansom,et al.  Mouse models of intestinal cancer , 2015, The Journal of pathology.

[298]  Emily J. Farrar,et al.  Notch-Tnf signalling is required for development and homeostasis of arterial valves , 2015, European heart journal.

[299]  T. Giordano,et al.  Notch signaling regulates gastric antral LGR5 stem cell function , 2015, The EMBO journal.

[300]  N. Papadopoulos,et al.  Dll4 Blockade in Stromal Cells Mediates Antitumor Effects in Preclinical Models of Ovarian Cancer. , 2015, Cancer research.

[301]  T. Buhl,et al.  NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas , 2015, International journal of cancer.

[302]  Bin Zhang,et al.  Notch1 downregulation combined with interleukin-24 inhibits invasion and migration of hepatocellular carcinoma cells. , 2015, World journal of gastroenterology.

[303]  T. Chatila,et al.  Control of peripheral tolerance by regulatory T cell-intrinsic Notch signaling , 2015, Nature Immunology.

[304]  R. Deberardinis,et al.  Metabolic reprogramming induces resistance to anti-NOTCH1 therapies in acute lymphoblastic leukemia , 2015, Nature Medicine.

[305]  F. Kuo,et al.  A Phase 1 study of the novel gamma-secretase inhibitor PF-03084014 in patients with T-cell acute lymphoblastic leukemia and T-cell lymphoblastic lymphoma , 2015, Blood Cancer Journal.

[306]  C. Rudin,et al.  A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo , 2015, Science Translational Medicine.

[307]  M. Duffy,et al.  ADAM10: a new player in breast cancer progression? , 2015, British Journal of Cancer.

[308]  J. Lupski,et al.  Rare variants in the notch signaling pathway describe a novel type of autosomal recessive Klippel–Feil syndrome , 2015, American journal of medical genetics. Part A.

[309]  Dong Eun Kim,et al.  Combined CSL and p53 downregulation promotes cancer-associated fibroblast activation , 2015, Nature Cell Biology.

[310]  E. Keller,et al.  Notch Pathway Inhibition Using PF-03084014, a γ-Secretase Inhibitor (GSI), Enhances the Antitumor Effect of Docetaxel in Prostate Cancer , 2015, Clinical Cancer Research.

[311]  Martin Vingron,et al.  Comprehensive genomic profiles of small cell lung cancer , 2015, Nature.

[312]  D. Lambrechts,et al.  Genomic landscape of carcinogen-induced and genetically induced mouse skin squamous cell carcinoma , 2015, Nature Medicine.

[313]  J. Aster,et al.  Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region. , 2015, Structure.

[314]  E. Ben-Jacob,et al.  Jagged mediates differences in normal and tumor angiogenesis by affecting tip-stalk fate decision , 2015, Proceedings of the National Academy of Sciences.

[315]  N. Perrimon,et al.  Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch. , 2015, Developmental cell.

[316]  E. D. Gregorio,et al.  The path forward. , 2015 .

[317]  J. T. Baeten,et al.  Differential Regulation of NOTCH2 and NOTCH3 Contribute to Their Unique Functions in Vascular Smooth Muscle Cells* , 2015, The Journal of Biological Chemistry.

[318]  R. Baron,et al.  Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow , 2015, The Journal of experimental medicine.

[319]  H. Mackay,et al.  A phase II study of single-agent RO4929097, a gamma-secretase inhibitor of Notch signaling, in patients with recurrent platinum-resistant epithelial ovarian cancer: A study of the Princess Margaret, Chicago and California phase II consortia. , 2015, Gynecologic oncology.

[320]  M. Fischer,et al.  Targeting Notch Signaling with a Notch2/Notch3 Antagonist (Tarextumab) Inhibits Tumor Growth and Decreases Tumor-Initiating Cell Frequency , 2015, Clinical Cancer Research.

[321]  D. Yamashiro,et al.  Notch suppresses angiogenesis and progression of hepatic metastases. , 2015, Cancer research.

[322]  A. Bhandoola,et al.  Transcriptional regulation of innate and adaptive lymphocyte lineages. , 2015, Annual review of immunology.

[323]  Jason A Inzana,et al.  Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. , 2015, Bone.

[324]  R. O’Keefe,et al.  A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis , 2015, Science Signaling.

[325]  E. Stanley,et al.  HUMAN DEFINITIVE HAEMOGENIC ENDOTHELIUM AND ARTERIAL VASCULAR ENDOTHELIUM REPRESENT DISTINCT LINEAGES , 2015, Nature Cell Biology.

[326]  K. English,et al.  Jagged-1 is required for the expansion of CD4+ CD25+ FoxP3+ regulatory T cells and tolerogenic dendritic cells by murine mesenchymal stromal cells , 2015, Stem Cell Research & Therapy.

[327]  A. Harris,et al.  A Phase I First-in-Human Study of Enoticumab (REGN421), a Fully Human Delta-like Ligand 4 (Dll4) Monoclonal Antibody in Patients with Advanced Solid Tumors , 2015, Clinical Cancer Research.

[328]  Bing Wang,et al.  The role of Notch signaling in muscle progenitor cell depletion and the rapid onset of histopathology in muscular dystrophy. , 2015, Human molecular genetics.

[329]  Rui Zhao,et al.  Injury induces direct lineage segregation of functionally distinct airway basal stem/progenitor cell subpopulations. , 2015, Cell stem cell.

[330]  O. Kranenburg.  Prometastatic NOTCH Signaling in Colon Cancer. , 2015, Cancer discovery.

[331]  K. Sakimura,et al.  Promotion of colorectal cancer invasion and metastasis through activation of NOTCH-DAB1-ABL-RHOGEF protein TRIO. , 2015, Cancer discovery.

[332]  V. Sondak,et al.  Phase 2 study of RO4929097, a gamma‐secretase inhibitor, in metastatic melanoma: SWOG 0933 , 2015, Cancer.

[333]  Hans Clevers,et al.  Long-Term Culture of Genome-Stable Bipotent Stem Cells from Adult Human Liver , 2015, Cell.

[334]  K. Alitalo,et al.  VEGFR3 does not sustain retinal angiogenesis without VEGFR2 , 2015, Proceedings of the National Academy of Sciences.

[335]  M. Pellegrini,et al.  Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. , 2014, Developmental cell.

[336]  B. Rueda,et al.  Notch signaling in serous ovarian cancer , 2014, Journal of Ovarian Research.

[337]  M. Corada,et al.  Signaling pathways in the specification of arteries and veins. , 2014, Arteriosclerosis, thrombosis, and vascular biology.

[338]  Herb Chen,et al.  Thiocoraline activates the Notch pathway in carcinoids and reduces tumor progression in vivo , 2014, Cancer Gene Therapy.

[339]  H. Ishwaran,et al.  Exosome Transfer from Stromal to Breast Cancer Cells Regulates Therapy Resistance Pathways , 2014, Cell.

[340]  Alexis Hubaud,et al.  Signalling dynamics in vertebrate segmentation , 2014, Nature Reviews Molecular Cell Biology.

[341]  Branimir Sikic,et al.  A Phase I Dose Escalation and Expansion Study of the Anticancer Stem Cell Agent Demcizumab (Anti-DLL4) in Patients with Previously Treated Solid Tumors , 2014, Clinical Cancer Research.

[342]  A. V. van Kampen,et al.  A central role for Notch in effector CD8+ T cell differentiation , 2014, Nature Immunology.

[343]  Inna Kuperstein,et al.  Concomitant Notch activation and p53 deletion trigger epithelial-to-mesenchymal transition and metastasis in mouse gut , 2014, Nature Communications.

[344]  A. Jimeno,et al.  A Phase I, Dose-Finding Study in Patients with Advanced Solid Malignancies of the Oral γ-Secretase Inhibitor PF-03084014 , 2014, Clinical Cancer Research.

[345]  A. Scorilas,et al.  A new tumor suppressor role for the Notch pathway in bladder cancer , 2014, Nature Medicine.

[346]  J. Roach,et al.  Mutations in NOTCH1 cause Adams-Oliver syndrome. , 2014, American journal of human genetics.

[347]  Yun Lu,et al.  The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2 , 2014, Genes & development.

[348]  Jian Sun,et al.  Genetic landscape of esophageal squamous cell carcinoma , 2014, Nature Genetics.

[349]  I. P. Newton,et al.  Direct contacts with colon cancer cells regulate the differentiation of bone marrow mesenchymal stem cells into tumor associated fibroblasts. , 2014, Biochemical and biophysical research communications.

[350]  A. Ferrando,et al.  N-Me, a long range oncogenic enhancer in T-cell acute lymphoblastic leukemia , 2014, Nature medicine.

[351]  Aristotelis Tsirigos,et al.  Genome-wide Mapping and Characterization of Notch-Regulated Long Noncoding RNAs in Acute Leukemia , 2014, Cell.

[352]  Will Liao,et al.  The cellular and molecular origin of tumor-associated macrophages , 2014, Science.

[353]  N. Monk,et al.  Compensatory Flux Changes within an Endocytic Trafficking Network Maintain Thermal Robustness of Notch Signaling , 2014, Cell.

[354]  J. Weill,et al.  Identification of a human splenic marginal zone B cell precursor with NOTCH2-dependent differentiation properties , 2014, The Journal of Experimental Medicine.

[355]  Emma R. Andersson,et al.  Therapeutic modulation of Notch signalling — are we there yet? , 2014, Nature Reviews Drug Discovery.

[356]  S. Arron,et al.  NOTCH1 mutations occur early during cutaneous squamous cell carcinogenesis , 2014, The Journal of investigative dermatology.

[357]  S. Serrano,et al.  Innate lymphoid cells integrate stromal and immune signals to enhance antibody production by splenic marginal zone B cells , 2014, Nature Immunology.

[358]  Herb Chen,et al.  Hesperetin Activates the Notch1 Signaling Cascade, Causes Apoptosis, and Induces Cellular Differentiation in Anaplastic Thyroid Cancer , 2014, Annals of Surgical Oncology.

[359]  J. Karp,et al.  Niche-independent high-purity cultures of Lgr5+ intestinal stem cells and their progeny , 2013, Nature Methods.

[360]  T. Golde,et al.  γ-Secretase inhibitors and modulators. , 2013, Biochimica et biophysica acta.

[361]  M. Maggioni,et al.  Hepatic Notch Signaling Correlates With Insulin Resistance and Nonalcoholic Fatty Liver Disease , 2013, Diabetes.

[362]  E. Puré,et al.  Notch1 is required for Kras-induced lung adenocarcinoma and controls tumor cell survival via p53. , 2013, Cancer research.

[363]  T. Curran,et al.  Phase I Study of Vismodegib in Children with Recurrent or Refractory Medulloblastoma: A Pediatric Brain Tumor Consortium Study , 2013, Clinical Cancer Research.

[364]  S. Ackerman,et al.  Notch1-induced brain tumor models the sonic hedgehog subgroup of human medulloblastoma. , 2013, Cancer Research.

[365]  L. Liaw,et al.  A Receptor-Specific Function for Notch2 in Mediating Vascular Smooth Muscle Cell Growth Arrest Through Cyclin-dependent Kinase Inhibitor 1B , 2013, Circulation research.

[366]  E. Siemers,et al.  A phase 3 trial of semagacestat for treatment of Alzheimer's disease. , 2013, The New England journal of medicine.

[367]  R. Fiorotto,et al.  Notch signaling regulates tubular morphogenesis during repair from biliary damage in mice. , 2013, Journal of Hepatology.

[368]  K. Capaccione,et al.  The Notch signaling pathway as a mediator of tumor survival. , 2013, Carcinogenesis.

[369]  M. Stratton,et al.  Whole exome sequencing of adenoid cystic carcinoma. , 2013, The Journal of clinical investigation.

[370]  N. Spinner,et al.  Renal involvement and the role of Notch signalling in Alagille syndrome , 2013, Nature Reviews Nephrology.

[371]  G. Gores,et al.  Notch-driven carcinogenesis: the merging of hepatocellular cancer and cholangiocarcinoma into a common molecular liver cancer subtype. , 2013, Journal of hepatology.

[372]  Tom V. Lee,et al.  Negative Regulation of Notch Signaling by Xylose , 2013, PLoS genetics.

[373]  K. Matsuo,et al.  Genetic evidence for association between NOTCH4 and schizophrenia supported by a GWAS follow-up study in a Japanese population , 2013, Molecular Psychiatry.

[374]  A. Joutel,et al.  Abnormal recruitment of extracellular matrix proteins by excess Notch3 ECD: a new pathomechanism in CADASIL. , 2013, Brain : a journal of neurology.

[375]  T. Carvalho,et al.  Bone marrow-derived CD11b+Jagged2+ cells promote epithelial-to-mesenchymal transition and metastasization in colorectal cancer. , 2013, Cancer research.

[376]  Benjamin J. Raphael,et al.  The Mutational Landscape of Adenoid Cystic Carcinoma , 2013, Nature Genetics.

[377]  Freddy Radtke,et al.  Regulation of innate and adaptive immunity by Notch , 2013, Nature Reviews Immunology.

[378]  Xunbo Jin,et al.  Inhibition of ADAM-17 more effectively down-regulates the Notch pathway than that of γ-secretase in renal carcinoma , 2013, Journal of experimental & clinical cancer research : CR.

[379]  J. Kissil,et al.  Notch signaling in pancreatic cancer: oncogene or tumor suppressor? , 2013, Trends in molecular medicine.

[380]  C. Eberhart,et al.  Prolonged Inhibition of Glioblastoma Xenograft Initiation and Clonogenic Growth following In Vivo Notch Blockade , 2013, Clinical Cancer Research.

[381]  W. Pear,et al.  T cell factor 1 is required for group 2 innate lymphoid cell generation. , 2013, Immunity.

[382]  T. D. de Gruijl,et al.  Notch controls generation and function of human effector CD8+ T cells. , 2013, Blood.

[383]  N. Perrimon,et al.  Complementary genomic screens identify SERCA as a therapeutic target in NOTCH1 mutated cancer. , 2013, Cancer cell.

[384]  Lauren J Donovan,et al.  Identification of a functional proprotein convertase cleavage site in microfibril-associated glycoprotein 2. , 2013, Matrix biology : journal of the International Society for Matrix Biology.

[385]  T. Yoneda,et al.  Spatiotemporal disorder in the axial skeleton development of the Mesp2-null mouse: a model of spondylocostal dysostosis and spondylothoracic dysostosis. , 2013, Bone.

[386]  Herb Chen,et al.  Chrysin activates Notch1 signaling and suppresses tumor growth of anaplastic thyroid carcinoma in vitro and in vivo , 2013, Cancer.

[387]  J. McMurray,et al.  Notch activation inhibits AML growth and survival: a potential therapeutic approach , 2013, The Journal of experimental medicine.

[388]  T. Ohtsuka,et al.  Accelerating the tempo of the segmentation clock by reducing the number of introns in the Hes7 gene. , 2013, Cell reports.

[389]  Ian Krop,et al.  Preclinical and Clinical Studies of Gamma Secretase Inhibitors with Docetaxel on Human Breast Tumors , 2013, Clinical Cancer Research.

[390]  H. Akiyama,et al.  Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development , 2013, Proceedings of the National Academy of Sciences.

[391]  Carlos Torroja,et al.  Mutations in the NOTCH pathway regulator MIB1 cause left ventricular noncompaction cardiomyopathy , 2013, Nature Medicine.

[392]  Jean Daudelin,et al.  Notch signaling regulates PD‐1 expression during CD8+ T‐cell activation , 2013, Immunology and cell biology.

[393]  J. Llovet,et al.  Notch signaling is activated in human hepatocellular carcinoma and induces tumor formation in mice. , 2012, Gastroenterology.

[394]  J. Avis,et al.  Direct observation of proteolytic cleavage at the S2 site upon forced unfolding of the Notch negative regulatory region , 2012, Proceedings of the National Academy of Sciences.

[395]  S. Akiyama,et al.  Dll4-Fc, an Inhibitor of Dll4-Notch Signaling, Suppresses Liver Metastasis of Small Cell Lung Cancer Cells through the Downregulation of the NF-κB Activity , 2012, Molecular Cancer Therapeutics.

[396]  P. Gaffney,et al.  RBPJ mutations identified in two families affected by Adams-Oliver syndrome. , 2012, American journal of human genetics.

[397]  Yuchen Jiao,et al.  Comparative genomic analysis of esophageal adenocarcinoma and squamous cell carcinoma. , 2012, Cancer discovery.

[398]  M. Dallman,et al.  Inflammatory Stimuli Cytokine Responses of Dendritic Cells to Noncanonical Notch Signaling Modulates , 2012 .

[399]  Robert Beckman,et al.  Phase I pharmacologic and pharmacodynamic study of the gamma secretase (Notch) inhibitor MK-0752 in adult patients with advanced solid tumors. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[400]  Naunpun Sangphech,et al.  Involvement of Notch signaling pathway in regulating IL-12 expression via c-Rel in activated macrophages. , 2012, Molecular immunology.

[401]  A. Reymond,et al.  Multifocal Epithelial Tumors and Field Cancerization from Loss of Mesenchymal CSL Signaling , 2012, Cell.

[402]  W. Ye,et al.  CCL2 mediates cross-talk between cancer cells and stromal fibroblasts that regulates breast cancer stem cells. , 2012, Cancer research.

[403]  T. Yeatman,et al.  A phase II study of RO4929097 in metastatic colorectal cancer. , 2012, European journal of cancer.

[404]  G. Garcia-Manero,et al.  Notch pathway activation induces neuroblastoma tumor cell growth arrest , 2012, Pediatric blood & cancer.

[405]  James X. Song,et al.  Phase I study of RO4929097, a gamma secretase inhibitor of Notch signaling, in patients with refractory metastatic or locally advanced solid tumors. , 2012, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[406]  T. Dawson,et al.  Botch promotes neurogenesis by antagonizing Notch. , 2012, Developmental cell.

[407]  Ryoichiro Kageyama,et al.  A Mechanism for Gene-Environment Interaction in the Etiology of Congenital Scoliosis , 2012, Cell.

[408]  T. Giordano,et al.  Upregulated JAG1 Enhances Cell Proliferation in Adrenocortical Carcinoma , 2012, Clinical Cancer Research.

[409]  D. Tuveson,et al.  Gamma secretase inhibition promotes hypoxic necrosis in mouse pancreatic ductal adenocarcinoma , 2012, The Journal of experimental medicine.

[410]  J. Epstein,et al.  Coordinating tissue interactions: Notch signaling in cardiac development and disease. , 2012, Developmental cell.

[411]  Nadja Ohlenhard,et al.  The tumour suppressor Lethal (2) giant discs is required for the function of the ESCRT-III component Shrub/CHMP4 , 2012, Journal of Cell Science.

[412]  S. Molyneux,et al.  Notch activation by the metalloproteinase ADAM17 regulates myeloproliferation and atopic barrier immunity by suppressing epithelial cytokine synthesis. , 2012, Immunity.

[413]  Jun Kanno,et al.  Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling , 2012, Nature Communications.

[414]  S. Artavanis-Tsakonas,et al.  Synergy between the ESCRT-III complex and Deltex defines a ligand-independent Notch signal , 2011, The Journal of cell biology.

[415]  C. Delidakis,et al.  Distinct intracellular motifs of Delta mediate its ubiquitylation and activation by Mindbomb1 and Neuralized , 2011, The Journal of cell biology.

[416]  A. Harris,et al.  Delta-like ligand 4-notch blockade and tumor radiation response. , 2011, Journal of the National Cancer Institute.

[417]  D. Tuveson,et al.  Crosstalk between the canonical NF-κB and Notch signaling pathways inhibits Pparγ expression and promotes pancreatic cancer progression in mice. , 2011, The Journal of clinical investigation.

[418]  R. Gerardy-Schahn,et al.  Molecular Cloning of a Xylosyltransferase That Transfers the Second Xylose to O-Glucosylated Epidermal Growth Factor Repeats of Notch* , 2011, The Journal of Biological Chemistry.

[419]  Steffen Jung,et al.  Notch2 receptor signaling controls functional differentiation of dendritic cells in the spleen and intestine. , 2011, Immunity.

[420]  A. Chinnaiyan,et al.  Functionally Recurrent Rearrangements of the MAST Kinase and Notch Gene Families in Breast Cancer , 2011, Nature Medicine.

[421]  David Haussler,et al.  Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma , 2011, Proceedings of the National Academy of Sciences.

[422]  D. Carbone,et al.  Resuscitating cancer immunosurveillance: selective stimulation of DLL1-Notch signaling in T cells rescues T-cell function and inhibits tumor growth. , 2011, Cancer research.

[423]  A. Sood,et al.  Biological roles of the Delta family Notch ligand Dll4 in tumor and endothelial cells in ovarian cancer. , 2011, Cancer research.

[424]  F. DiMeco,et al.  Endothelial cells create a stem cell niche in glioblastoma by providing NOTCH ligands that nurture self-renewal of cancer stem-like cells. , 2011, Cancer research.

[425]  J. Olson,et al.  Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. , 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[426]  S. Thorgeirsson,et al.  Notch signaling inhibits hepatocellular carcinoma following inactivation of the RB pathway , 2011, The Journal of experimental medicine.

[427]  Didier Y. R. Stainier,et al.  Molecular control of endothelial cell behaviour during blood vessel morphogenesis , 2011, Nature Reviews Molecular Cell Biology.

[428]  P. Sham,et al.  Hedgehog/Notch-induced premature gliogenesis represents a new disease mechanism for Hirschsprung disease in mice and humans. , 2011, The Journal of clinical investigation.

[429]  R. Gibbs,et al.  Exome Sequencing of Head and Neck Squamous Cell Carcinoma Reveals Inactivating Mutations in NOTCH1 , 2011, Science.

[430]  S. Dunwoodie,et al.  A cell autonomous role for the Notch ligand Delta‐like 3 in αβ T‐cell development , 2011, Immunology and Cell Biology.

[431]  K. Jones,et al.  Activated Notch1 induces lung adenomas in mice and cooperates with Myc in the generation of lung adenocarcinoma. , 2011, Cancer research.

[432]  A. Sood,et al.  Targeting the Notch Ligand Jagged1 in Both Tumor Cells and Stroma in Ovarian Cancer , 2011, Clinical Cancer Research.

[433]  H. Takeuchi,et al.  O-Glucose Trisaccharide Is Present at High but Variable Stoichiometry at Multiple Sites on Mouse Notch1* , 2011, The Journal of Biological Chemistry.

[434]  A. Kriegstein,et al.  Development and Evolution of the Human Neocortex , 2011, Cell.

[435]  A. McKenna,et al.  The Mutational Landscape of Head and Neck Squamous Cell Carcinoma , 2011, Science.

[436]  Javier Bermejo,et al.  Diet-Induced Aortic Valve Disease in Mice Haploinsufficient for the Notch Pathway Effector RBPJK/CSL , 2011, Arteriosclerosis, thrombosis, and vascular biology.

[437]  D. Conrad,et al.  Hematopoietic cytokine-induced transcriptional regulation and Notch signaling as modulators of MDSC expansion. , 2011, International immunopharmacology.

[438]  E. Fuchs,et al.  A Role for the Primary Cilium in Notch Signaling and Epidermal Differentiation during Skin Development , 2011, Cell.

[439]  B. Hogan,et al.  Notch-dependent differentiation of adult airway basal stem cells. , 2011, Cell stem cell.

[440]  Benjamin J. Raphael,et al.  Integrated Genomic Analyses of Ovarian Carcinoma , 2011, Nature.

[441]  Olivier Pourquié,et al.  Vertebrate Segmentation: From Cyclic Gene Networks to Scoliosis , 2011, Cell.

[442]  P. Stanley,et al.  Protein O-fucosyltransferase 1 (Pofut1) regulates lymphoid and myeloid homeostasis through modulation of Notch receptor ligand interactions. , 2011, Blood.

[443]  H. Takeuchi,et al.  Regulation of mammalian Notch signaling and embryonic development by the protein O-glucosyltransferase Rumi , 2011, Development.

[444]  Y. N. Park,et al.  Notch1 differentially regulates oncogenesis by wildtype p53 overexpression and p53 mutation in grade III hepatocellular carcinoma , 2011, Hepatology.

[445]  Pierre Lindenbaum,et al.  Truncating mutations in the last exon of NOTCH2 cause a rare skeletal disorder with osteoporosis , 2011, Nature Genetics.

[446]  G. Goodall,et al.  The Notch ligand Jagged2 promotes lung adenocarcinoma metastasis through a miR-200-dependent pathway in mice. , 2011, The Journal of clinical investigation.

[447]  S. Robertson,et al.  Mutations in NOTCH2 cause Hajdu-Cheney syndrome, a disorder of severe and progressive bone loss , 2011, Nature Genetics.

[448]  R. Shivdasani,et al.  Notch signaling in stomach epithelial stem cell homeostasis , 2011, The Journal of experimental medicine.

[449]  S. Makni,et al.  The role of the Notch pathway in healthy and osteoarthritic articular cartilage: from experimental models to ex vivo studies , 2011, Arthritis research & therapy.

[450]  E. Kremmer,et al.  Notch inhibition by the ligand DELTA-LIKE 3 defines the mechanism of abnormal vertebral segmentation in spondylocostal dysostosis. , 2011, Human molecular genetics.

[451]  Fang Gao,et al.  Notch signaling contributes to the maintenance of both normal neural stem cells and patient-derived glioma stem cells , 2011, BMC Cancer.

[452]  A. Gaultier,et al.  Translocation of the cytoplasmic domain of ADAM13 to the nucleus is essential for Calpain8-a expression and cranial neural crest cell migration. , 2011, Developmental cell.

[453]  Masahiro Aoki,et al.  Suppression of colon cancer metastasis by Aes through inhibition of Notch signaling. , 2011, Cancer cell.

[454]  H. Pasolli,et al.  Asymmetric Cell Divisions Promote Notch-Dependent Epidermal Differentiation , 2011, Nature.

[455]  G. Weinmaster,et al.  Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome , 2010, Development.

[456]  H. Macdonald,et al.  Hes1 is a critical but context-dependent mediator of canonical Notch signaling in lymphocyte development and transformation. , 2010, Immunity.

[457]  Baoxi Wang,et al.  γ-Secretase Gene Mutations in Familial Acne Inversa , 2010, Science.

[458]  Andrew Wang,et al.  Targeting ADAM-17/notch signaling abrogates the development of systemic sclerosis in a murine model. , 2010, Arthritis and rheumatism.

[459]  Raphael Kopan.  Faculty Opinions recommendation of Gamma-secretase gene mutations in familial acne inversa. , 2010 .

[460]  H. Gerhardt,et al.  Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting , 2010, Nature Cell Biology.

[461]  A. Extance.  Alzheimer's failure raises questions about disease-modifying strategies , 2010, Nature Reviews Drug Discovery.

[462]  Luis Luna-Zurita,et al.  Integration of a Notch-dependent mesenchymal gene program and Bmp2-driven cell invasiveness regulates murine cardiac valve formation. , 2010, The Journal of clinical investigation.

[463]  A. Ross,et al.  Cancer esearch apeutics , Targets , and Chemical Biology ecretase Inhibitors Enhance Temozolomide Treatment uman Gliomas by Inhibiting Neurosphere R opulation and Xenograft Recurrence , 2010 .

[464]  I. Shih,et al.  Notch3 overexpression is related to the recurrence of ovarian cancer and confers resistance to carboplatin. , 2010, The American journal of pathology.

[465]  H. Takeuchi,et al.  Role of glycosylation of Notch in development. , 2010, Seminars in cell & developmental biology.

[466]  H. Jafar-Nejad,et al.  Role of glycans and glycosyltransferases in the regulation of Notch signaling. , 2010, Glycobiology.

[467]  R. Rad,et al.  Notch2 is required for progression of pancreatic intraepithelial neoplasia and development of pancreatic ductal adenocarcinoma , 2010, Proceedings of the National Academy of Sciences.

[468]  Xingbin Hu,et al.  Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses. , 2010, Cancer Research.

[469]  J. Kissil,et al.  Notch1 functions as a tumor suppressor in a model of K-ras-induced pancreatic ductal adenocarcinoma. , 2010, Cancer research.

[470]  D. Sillence,et al.  Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis , 2010, European Journal of Human Genetics.

[471]  R. Depping,et al.  Notch1 signaling is mediated by importins alpha 3, 4, and 7 , 2010, Cellular and Molecular Life Sciences.

[472]  T. Honjo,et al.  RBPjκ-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development , 2010, Development.

[473]  Erin E. Sparks,et al.  Notch signaling regulates formation of the three‐dimensional architecture of intrahepatic bile ducts in mice , 2010, Hepatology.

[474]  Ian A. White,et al.  Endothelial cells are essential for the self-renewal and repopulation of Notch-dependent hematopoietic stem cells. , 2010, Cell stem cell.

[475]  A. Schedl,et al.  Cerebrovascular dysfunction and microcirculation rarefaction precede white matter lesions in a mouse genetic model of cerebral ischemic small vessel disease. , 2010, The Journal of clinical investigation.

[476]  R. Clarke,et al.  Tumor and Stem Cell Biology Cancer Research Regulation of Breast Cancer Stem Cell Activity by Signaling through the Notch 4 Receptor , 2010 .

[477]  T. Dang,et al.  Targeting specific regions of the Notch3 ligand-binding domain induces apoptosis and inhibits tumor growth in lung cancer. , 2010, Cancer research.

[478]  G. Pelosi,et al.  Alterations of the Notch pathway in lung cancer , 2009, Proceedings of the National Academy of Sciences.

[479]  Liang Qiao,et al.  Role of Notch signaling in colorectal cancer. , 2009, Carcinogenesis.

[480]  R. Gerardy-Schahn,et al.  Identification of Glycosyltransferase 8 Family Members as Xylosyltransferases Acting on O-Glucosylated Notch Epidermal Growth Factor Repeats* , 2009, The Journal of Biological Chemistry.

[481]  W. Pear,et al.  Notch signaling is a critical regulator of allogeneic CD4+ T-cell responses mediating graft-versus-host disease. , 2009, Blood.

[482]  C. Brosnan,et al.  Notch1 signaling plays a role in regulating precursor differentiation during CNS remyelination , 2009, Proceedings of the National Academy of Sciences.

[483]  G. Richards,et al.  Origin and evolution of the Notch signalling pathway: an overview from eukaryotic genomes , 2009, BMC Evolutionary Biology.

[484]  D. Carvajal,et al.  Preclinical profile of a potent gamma-secretase inhibitor targeting notch signaling with in vivo efficacy and pharmacodynamic properties. , 2009, Cancer research.

[485]  Chengqun Huang,et al.  NOTCH3 SIGNALING IS REQUIRED FOR THE DEVELOPMENT OF PULMONARY ARTERIAL HYPERTENSION , 2009, Nature Medicine.

[486]  J. Posakony,et al.  Both inhibition and activation of Notch signaling rely on a conserved Neuralized-binding motif in Bearded proteins and the Notch ligand Delta. , 2009, Developmental biology.

[487]  K. Yutzey,et al.  Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development , 2009, Proceedings of the National Academy of Sciences.

[488]  S. Dunwoodie.  The role of Notch in patterning the human vertebral column. , 2009, Current Opinion in Genetics and Development.

[489]  Raphael Kopan,et al.  Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. , 2009, Cancer cell.

[490]  Je-in Youn,et al.  Notch and wingless signaling cooperate in regulation of dendritic cell differentiation. , 2009, Immunity.

[491]  F. Tronche,et al.  Intrahepatic bile ducts develop according to a new mode of tubulogenesis regulated by the transcription factor SOX9. , 2009, Gastroenterology.

[492]  Choon-Sik Park,et al.  Gamma-secretase inhibitor reduces allergic pulmonary inflammation by modulating Th1 and Th2 responses. , 2009, American journal of respiratory and critical care medicine.

[493]  B. Stanger,et al.  Notch signaling controls liver development by regulating biliary differentiation , 2009, Development.

[494]  R. Haltiwanger,et al.  Role of unusual O-glycans in intercellular signaling. , 2009, The international journal of biochemistry & cell biology.

[495]  M. Seto,et al.  Gain‐of‐function mutations and copy number increases of Notch2 in diffuse large B‐cell lymphoma , 2009, Cancer science.

[496]  P. Majumder,et al.  Inhibition of gamma-secretase activity inhibits tumor progression in a mouse model of pancreatic ductal adenocarcinoma. , 2009, Gastroenterology.

[497]  K. Kaestner,et al.  Ductal malformation and pancreatitis in mice caused by conditional Jag1 deletion. , 2009, Gastroenterology.

[498]  Raphael Kopan,et al.  The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism , 2009, Cell.

[499]  S. Artavanis-Tsakonas,et al.  Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine , 2009, Proceedings of the National Academy of Sciences.

[500]  Hua Han,et al.  Transcription factor RBP-J-mediated signaling represses the differentiation of neural stem cells into intermediate neural progenitors , 2009, Molecular and Cellular Neuroscience.

[501]  A. Dvorak,et al.  Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation. , 2009, Blood.

[502]  T. Golde,et al.  Notch Regulates Cytolytic Effector Function in CD8+ T Cells1 , 2009, Journal of Immunology.

[503]  J. Aster,et al.  Notch signaling mediates G1/S cell-cycle progression in T cells via cyclin D3 and its dependent kinases. , 2009, Blood.

[504]  R. Flavell,et al.  The different faces of Notch in T-helper-cell differentiation , 2009, Nature Reviews Immunology.

[505]  I. Screpanti,et al.  Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells. , 2009, Blood.

[506]  Holger Gerhardt,et al.  Nrarp coordinates endothelial Notch and Wnt signaling to control vessel density in angiogenesis. , 2009, Developmental cell.

[507]  A. Ferrando,et al.  Gamma-secretase inhibitors reverse glucocorticoid resistance in T-ALL , 2008, Nature Medicine.

[508]  E. Bellefroid,et al.  Hairy2 functions through both DNA-binding and non DNA-binding mechanisms at the neural plate border in Xenopus. , 2008, Developmental biology.

[509]  U. Lendahl,et al.  Notch-1 associates with IKKα and regulates IKK activity in cervical cancer cells , 2008, Oncogene.

[510]  S. Sone,et al.  Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity , 2008, Nature Immunology.

[511]  J. Becker,et al.  Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos. , 2008, Blood.

[512]  T. Golde,et al.  Notch1 and TGFbeta1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. , 2008, Blood.

[513]  D. Edwards,et al.  The ADAM metalloproteinases , 2008, Molecular Aspects of Medicine.

[514]  I. Shih,et al.  Jagged-1 and Notch3 juxtacrine loop regulates ovarian tumor growth and adhesion. , 2008, Cancer research.

[515]  Jianzhong Huang,et al.  A notch1 ectodomain construct inhibits endothelial notch signaling, tumor growth, and angiogenesis. , 2008, Cancer research.

[516]  M. Wolfe,et al.  Substrate-targeting γ-secretase modulators , 2008, Nature.

[517]  A. Karsan,et al.  Notch Signaling in Cardiac Development , 2008, Circulation research.

[518]  P. Stanley,et al.  Roles of Pofut1 and O-Fucose in Mammalian Notch Signaling* , 2008, Journal of Biological Chemistry.

[519]  A. Korczyn.  The amyloid cascade hypothesis , 2008, Alzheimer's & Dementia.

[520]  Christopher C W Hughes,et al.  Crosstalk between vascular endothelial growth factor, notch, and transforming growth factor-beta in vascular morphogenesis. , 2008, Circulation research.

[521]  J. Aster,et al.  Modulation of Notch Signaling by Antibodies Specific for the Extracellular Negative Regulatory Region of NOTCH3* , 2008, Journal of Biological Chemistry.

[522]  Shinya Watanabe,et al.  NOTCH3 signaling pathway plays crucial roles in the proliferation of ErbB2-negative human breast cancer cells. , 2008, Cancer research.

[523]  Tatsuya Kobayashi,et al.  Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation , 2008, Nature Medicine.

[524]  P. Portin,et al.  Interaction of master mind, big brain, neuralized and Notch genes of Drosophila melanogaster as expressed in adult morphology. , 2008, Hereditas.

[525]  K. Kaestner,et al.  Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development , 2008, Proceedings of the National Academy of Sciences.

[526]  P. Stanley,et al.  The O-fucose glycan in the ligand-binding domain of Notch1 regulates embryogenesis and T cell development , 2008, Proceedings of the National Academy of Sciences.

[527]  P. Mazur,et al.  Notch signaling is required for exocrine regeneration after acute pancreatitis. , 2008, Gastroenterology.

[528]  H. Bellen,et al.  Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling , 2008, Cell.

[529]  Pier Paolo Di Fiore,et al.  NUMB controls p53 tumour suppressor activity , 2008, Nature.

[530]  S. Kaufmann,et al.  Notch signaling is activated by TLR stimulation and regulates macrophage functions , 2008, European journal of immunology.

[531]  W. Pear,et al.  Notch1 engagement by Delta-like-1 promotes differentiation of B lymphocytes to antibody-secreting cells , 2007, Proceedings of the National Academy of Sciences.

[532]  F. Radtke,et al.  Notch and cancer: a double-edged sword , 2007, Cellular and Molecular Life Sciences.

[533]  D. Suskind,et al.  Increasing the mutation rate for jagged1 mutations in patients with Alagille syndrome , 2007, Hepatology.

[534]  Jos Jonkers,et al.  MMTV insertional mutagenesis identifies genes, gene families and pathways involved in mammary cancer , 2007, Nature Genetics.

[535]  J. Aster,et al.  Structural basis for autoinhibition of Notch , 2007, Nature Structural &Molecular Biology.

[536]  E. Ballestar,et al.  Notch signaling is essential for ventricular chamber development. , 2007, Developmental cell.

[537]  A. Böttger,et al.  The Notch signaling pathway in the cnidarian Hydra. , 2007, Developmental biology.

[538]  G. Thurston,et al.  Delta-like ligand 4 (Dll4) is induced by VEGF as a negative regulator of angiogenic sprouting , 2007, Proceedings of the National Academy of Sciences.

[539]  Antonio Duarte,et al.  The Notch ligand Delta-like 4 negatively regulates endothelial tip cell formation and vessel branching , 2007, Proceedings of the National Academy of Sciences.

[540]  Holger Gerhardt,et al.  Dll4 signalling through Notch1 regulates formation of tip cells during angiogenesis , 2007, Nature.

[541]  J. Gutkind,et al.  G-protein-coupled receptors and cancer , 2007, Nature Reviews Cancer.

[542]  J. Epstein,et al.  An essential role for Notch in neural crest during cardiovascular development and smooth muscle differentiation. , 2007, The Journal of clinical investigation.

[543]  F. Fazekas,et al.  Notch1 and its ligand Jagged1 are present in remyelination in a T-cell- and antibody-mediated model of inflammatory demyelination , 2007, Acta Neuropathologica.

[544]  F. Real,et al.  Nuclear IKK activity leads to dysregulated Notch-dependent gene expression in colorectal cancer , 2007, Proceedings of the National Academy of Sciences.

[545]  Herb Chen,et al.  Overexpression of the NOTCH1 Intracellular Domain Inhibits Cell Proliferation and Alters the Neuroendocrine Phenotype of Medullary Thyroid Cancer Cells* , 2006, Journal of Biological Chemistry.

[546]  Minhong Yan,et al.  Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis , 2006, Nature.

[547]  Jie Chen,et al.  A Complex Oscillating Network of Signaling Genes Underlies the Mouse Segmentation Clock , 2006, Science.

[548]  A. Fischer,et al.  Developmental patterning of the cardiac atrioventricular canal by Notch and Hairy-related transcription factors , 2006, Development.

[549]  L. Chatenoud,et al.  Jagged2-expressing hematopoietic progenitors promote regulatory T cell expansion in the periphery through notch signaling. , 2006, Immunity.

[550]  A. Israël,et al.  Itch/AIP4 mediates Deltex degradation through the formation of K29‐linked polyubiquitin chains , 2006, EMBO reports.

[551]  A. Villemain,et al.  The role of the vascular endothelial growth factor-Delta-like 4 ligand/Notch4-ephrin B2 cascade in tumor vessel remodeling and endothelial cell functions. , 2006, Cancer research.

[552]  W. Pear,et al.  Impaired notch signaling promotes de novo squamous cell carcinoma formation. , 2006, Cancer research.

[553]  G. Anderson,et al.  The thymus and T-cell commitment: the right niche for Notch? , 2006, Nature Reviews Immunology.

[554]  I. Krantz,et al.  NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. , 2006, American journal of human genetics.

[555]  J. Aster,et al.  A phase I clinical trial of the notch inhibitor MK-0752 in patients with T-cell acute lymphoblastic leukemia/lymphoma (T-ALL) and other leukemias. , 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[556]  Tian-Li Wang,et al.  Notch3 gene amplification in ovarian cancer. , 2006, Cancer research.

[557]  J. Aster,et al.  Leukemia-Associated Mutations within the NOTCH1 Heterodimerization Domain Fall into at Least Two Distinct Mechanistic Classes , 2006, Molecular and Cellular Biology.

[558]  D. Piccoli,et al.  Jagged1 (JAG1) mutations in Alagille syndrome: increasing the mutation detection rate , 2006, Human mutation.

[559]  A. Look,et al.  Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia , 2006, Nature Reviews Cancer.

[560]  Jian Wang,et al.  Cross-regulation between Notch and p63 in keratinocyte commitment to differentiation. , 2006, Genes & development.

[561]  Jon C. Aster,et al.  Structural Basis for Cooperativity in Recruitment of MAML Coactivators to Notch Transcription Complexes , 2006, Cell.

[562]  B. Giebel,et al.  Tumor Suppressors: Control of Signaling by Endocytosis , 2006, Current Biology.

[563]  Angeliki Louvi,et al.  Notch signalling in vertebrate neural development , 2006, Nature Reviews Neuroscience.

[564]  D. Massi,et al.  Evidence for differential expression of Notch receptors and their ligands in melanocytic nevi and cutaneous malignant melanoma , 2006, Modern Pathology.

[565]  Ariel D. Chipman,et al.  Arthropod Segmentation: beyond the Drosophila paradigm , 2005, Nature Reviews Genetics.

[566]  S. Cohen,et al.  Tumor suppressor properties of the ESCRT-II complex component Vps25 in Drosophila. , 2005, Developmental cell.

[567]  D. Bilder,et al.  The Drosophila tumor suppressor vps25 prevents nonautonomous overproliferation by regulating notch trafficking. , 2005, Developmental cell.

[568]  G. Lockwood,et al.  High-level coexpression of JAG1 and NOTCH1 is observed in human breast cancer and is associated with poor overall survival. , 2005, Cancer research.

[569]  M. Fey,et al.  The Notch pathway in ovarian carcinomas and adenomas , 2005, British Journal of Cancer.

[570]  G. Struhl,et al.  Distinct roles for Mind bomb, Neuralized and Epsin in mediating DSL endocytosis and signaling in Drosophila , 2005, Development.

[571]  J. Joyce,et al.  Therapeutic Targeting of the Tumor Microenvironment. , 2021, Cancer discovery.

[572]  Fu-Jung Lin,et al.  Suppression of Notch signalling by the COUP-TFII transcription factor regulates vein identity , 2005, Nature.

[573]  F. Schweisguth,et al.  Two Distinct E3 Ubiquitin Ligases Have Complementary Functions in the Regulation of Delta and Serrate Signaling in Drosophila , 2005, PLoS biology.

[574]  Q. Su,et al.  Expression of Notch-1 and its ligands, Delta-like-1 and Jagged-1, is critical for glioma cell survival and proliferation. , 2005, Cancer research.

[575]  B. Lévy,et al.  Impaired Vascular Mechanotransduction in a Transgenic Mouse Model of CADASIL Arteriopathy , 2005, Stroke.

[576]  Erin Fitch,et al.  Fat facets and Liquid facets promote Delta endocytosis and Delta signaling in the signaling cells , 2004, Development.

[577]  Andrew P. Weng,et al.  Activating Mutations of NOTCH1 in Human T Cell Acute Lymphoblastic Leukemia , 2004, Science.

[578]  S. Varambally,et al.  JAGGED1 Expression Is Associated with Prostate Cancer Metastasis and Recurrence , 2004, Cancer Research.

[579]  K. Kusumi,et al.  Klippel-Feil syndrome: clinical features and current understanding of etiology. , 2004, Clinical orthopaedics and related research.

[580]  D. Sillence,et al.  Mutated MESP2 causes spondylocostal dysostosis in humans. , 2004, American journal of human genetics.

[581]  N. Tamaoki,et al.  Delta-like 1 is necessary for the generation of marginal zone B cells but not T cells in vivo , 2004, Nature Immunology.

[582]  Robert C. Bast,et al.  Selection of Potential Markers for Epithelial Ovarian Cancer with Gene Expression Arrays and Recursive Descent Partition Analysis , 2004, Clinical Cancer Research.

[583]  Michael D. Schneider,et al.  BMP10 is essential for maintaining cardiac growth during murine cardiogenesis , 2004, Development.

[584]  Manfred Gessler,et al.  The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. , 2004, Genes & development.

[585]  P. Amrolia,et al.  Overexpression of the Notch ligand, Jagged-1, induces alloantigen-specific human regulatory T cells. , 2003, Blood.

[586]  N. Perrimon,et al.  neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions , 2003, Development.

[587]  Julian Lewis.  Autoinhibition with Transcriptional Delay A Simple Mechanism for the Zebrafish Somitogenesis Oscillator , 2003, Current Biology.

[588]  Ryoichiro Kageyama,et al.  Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock. , 2003, Genes & development.

[589]  Michael S. Wolfe,et al.  γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[590]  P. Stanley,et al.  Protein O-fucosyltransferase 1 is an essential component of Notch signaling pathways , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[591]  Hans Clevers,et al.  Notch1 functions as a tumor suppressor in mouse skin , 2003, Nature Genetics.

[592]  Mary-Lee Dequéant,et al.  Periodic Notch inhibition by Lunatic Fringe underlies the chick segmentation clock , 2003, Nature.

[593]  Wenli Wang,et al.  Determinants of Notch-3 Receptor Expression and Signaling in Vascular Smooth Muscle Cells: Implications in Cell-Cycle Regulation , 2002, Circulation research.

[594]  K. Arima,et al.  Arterial Changes in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy (CADASIL) in Relation to Pathogenesis of Diffuse Myelin Loss of Cerebral White Matter: Examination of Cerebral Medullary Arteries by Reconstruction of Serial Sections of an Autopsy Case , 2002, Stroke.

[595]  Marie-Christine Chaboissier,et al.  The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6. , 2002, Genes & development.

[596]  C. Brosnan,et al.  Multiple sclerosis: Re-expression of a developmental pathway that restricts oligodendrocyte maturation , 2002, Nature Medicine.

[597]  M. Fortini,et al.  Signalling: γ-Secretase-mediated proteolysis in cell-surface-receptor signalling , 2002, Nature Reviews Molecular Cell Biology.

[598]  T. Vogt,et al.  Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesis. , 2002, Developmental cell.

[599]  B. Hogan,et al.  The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. , 2001, Genes & development.

[600]  M. Hadchouel,et al.  Outcome of liver disease in children with Alagille syndrome: a study of 163 patients , 2001, Gut.

[601]  I. Krantz,et al.  Mutation analysis of Jagged1 (JAG1) in Alagille syndrome patients , 2001, Human mutation.

[602]  Raphael Kopan,et al.  Notch signaling: from the outside in. , 2000, Developmental biology.

[603]  David Ish-Horowicz,et al.  Notch signalling and the synchronization of the somite segmentation clock , 2000, Nature.

[604]  J. Schlessinger,et al.  Cell Signaling by Receptor Tyrosine Kinases , 2000, Cell.

[605]  Yang Wang,et al.  Fringe is a glycosyltransferase that modifies Notch , 2000, Nature.

[606]  B. Tombal,et al.  Delayed micromolar elevation in intracellular calcium precedes induction of apoptosis in thapsigargin-treated breast cancer cells. , 2000, Clinical cancer research : an official journal of the American Association for Cancer Research.

[607]  Min Xu,et al.  Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1 , 2000, Nature.

[608]  J. Sundberg,et al.  Notch signaling is essential for vascular morphogenesis in mice. , 2000, Genes & development.

[609]  Min Xu,et al.  Presenilin 1 is linked with gamma-secretase activity in the detergent solubilized state. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[610]  E. Lander,et al.  Mutations in the human Delta homologue, DLL3, cause axial skeletal defects in spondylocostal dysostosis , 2000, Nature Genetics.

[611]  A. Garcı́a-Bellido,et al.  Notch signaling directly controls cell proliferation in the Drosophila wing disc. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[612]  R. Callahan,et al.  MMTV-induced mammary tumorigenesis: gene discovery, progression to malignancy and cellular pathways , 2000, Oncogene.

[613]  Raphael Kopan,et al.  A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. , 2000, Molecular cell.

[614]  M. Fortini,et al.  Ca2+‐ATPase function is required for intracellular trafficking of the Notch receptor in Drosophila , 1999, The EMBO journal.

[615]  David J. Anderson,et al.  Notch signalling controls pancreatic cell differentiation , 1999, Nature.

[616]  S. Artavanis-Tsakonas,et al.  Notch Signaling : Cell Fate Control and Signal Integration in Development , 1999 .

[617]  M. Tsai,et al.  The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development. , 1999, Genes & development.

[618]  M. Fortini,et al.  Neurogenic phenotypes and altered Notch processing in Drosophila Presenilin mutants , 1999, Nature.

[619]  P Bailey,et al.  Double Edged Sword , 2002 .

[620]  T. Gridley,et al.  Defects in somite formation in lunatic fringe-deficient mice , 1998, Nature.

[621]  B. Birren,et al.  The mouse pudgy mutation disrupts Delta homologue Dll3 and initiation of early somite boundaries , 1998, Nature Genetics.

[622]  S. Christensen,et al.  A tool coming of age: thapsigargin as an inhibitor of sarco-endoplasmic reticulum Ca(2+)-ATPases. , 1998, Trends in pharmacological sciences.

[623]  J. Weissenbach,et al.  Strong clustering and stereotyped nature of Notch3 mutations in CADASIL patients , 1997, The Lancet.

[624]  Paul S. Meltzer,et al.  Mutations in the human Jagged1 gene are responsible for Alagille syndrome , 1997, Nature Genetics.

[625]  Colin C. Collins,et al.  Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1 , 1997, Nature Genetics.

[626]  J. Weissenbach,et al.  Notch3 mutations in CADASIL, a hereditary adult-onset condition causing stroke and dementia , 1996, Nature.

[627]  J. Sklar,et al.  Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles , 1996, The Journal of experimental medicine.

[628]  S. Minoguchi,et al.  Physical interaction between a novel domain of the receptor Notch and the transcription factor RBP-Jκ/Su(H) , 1995, Current Biology.

[629]  S. Younkin,et al.  An increased percentage of long amyloid beta protein secreted by familial amyloid beta protein precursor (beta APP717) mutants. , 1994, Science.

[630]  R. Haddon.  From the outside in , 1994, Nature.

[631]  A. Joutel,et al.  Autosomal Dominant Leukoencephalopathy and Subcortical Ischemic Stroke: A Clinicopathological Study , 1993, Stroke.

[632]  J. Hardy,et al.  Alzheimer's disease: the amyloid cascade hypothesis. , 1992, Science.

[633]  D. Selkoe,et al.  Processing of the amyloid protein precursor to potentially amyloidogenic derivatives. , 1992, Science.

[634]  J. Sklar,et al.  TAN-1, the human homolog of the Drosophila Notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms , 1991, Cell.

[635]  A. Bui,et al.  cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[636]  W. Harris,et al.  Xotch, the Xenopus homolog of Drosophila notch. , 1990, Science.

[637]  R. J. Fleming,et al.  The Notch locus and the genetic circuitry involved in early Drosophila neurogenesis. , 1990, Genes & development.

[638]  S. Artavanis-Tsakonas,et al.  The notch gene product is a glycoprotein expressed on the cell surface of both epidermal and neuronal precursor cells during Drosophila development , 1989, The Journal of cell biology.

[639]  J. Campos-Ortega,et al.  The molecular genetics of early neurogenesis in Drosophila melanogaster , 1989, BioEssays : news and reviews in molecular, cellular and developmental biology.

[640]  J. Kimble,et al.  Transcript analysis of glp-1 and lin-12, homologous genes required for cell interactions during development of C. elegans , 1989, Cell.

[641]  R. Cagan,et al.  Notch is required for successive cell decisions in the developing Drosophila retina. , 1989, Genes & development.

[642]  Kathleen Weston,et al.  The Caenorhabditis elegans lin-12 gene encodes a transmembrane protein with overall similarity to Drosophila Notch , 1988, Nature.

[643]  David A. Agard,et al.  Precise determination of the molecular limits of a polytene chromosome band: Regulatory sequences for the Notch gene are in the interband , 1988, Cell.

[644]  J. Kimble,et al.  glp-1 Is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans , 1987, Cell.

[645]  M. W. Young,et al.  Mutations altering the structure of epidermal growth factor-like coding sequences at the Drosophila Notch locus , 1987, Cell.

[646]  S. Artavanis-Tsakonas,et al.  The embryonic expression of the Notch locus of Drosophila melanogaster and the implications of point mutations in the extracellular EGF‐like domain of the predicted protein. , 1987, The EMBO journal.

[647]  L. Breeden,et al.  Similarity between cell-cycle genes of budding yeast and fission yeast and the Notch gene of Drosophila , 1987, Nature.

[648]  J. Sklar,et al.  Analysis of DNA surrounding the breakpoints of chromosomal translocations involving the β T cell receptor gene in human lymphoblastic neoplasms , 1987, Cell.

[649]  D. Gallahan,et al.  A new common integration region (int-3) for mouse mammary tumor virus on mouse chromosome 17 , 1987, Journal of virology.

[650]  M. W. Young,et al.  Transposon-dependent mutant phenotypes at the Notch locus of Drosophila , 1986, Nature.

[651]  M. W. Young,et al.  Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors , 1986, Molecular and cellular biology.

[652]  S. Artavanis-Tsakonas,et al.  Nucleotide sequence from the neurogenic locus Notch implies a gene product that shares homology with proteins containing EGF-like repeats , 1985, Cell.

[653]  H. Horvitz,et al.  The lin-12 locus specifies cell fates in caenorhabditis elegans , 1983, Cell.

[654]  S. Artavanis-Tsakonas,et al.  Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. , 1983, Proceedings of the National Academy of Sciences of the United States of America.

[655]  O. L. Mohr.  Character Changes Caused by Mutation of an Entire Region of a Chromosome in Drosophila. , 1919, Genetics.

[656]  C. W. Metz,et al.  Incompatibility of Mutant Races in Drosophila. , 1917, Proceedings of the National Academy of Sciences of the United States of America.

[657]  C. Bridges,et al.  Non-Disjunction as Proof of the Chromosome Theory of Heredity (Concluded). , 1916, Genetics.

[658]  K. Nackaerts,et al.  Efficacy and Safety of Rovalpituzumab Tesirine Compared With Topotecan as Second-Line Therapy in DLL3-High SCLC: Results From the Phase 3 TAHOE Study , 2021 .

[659]  M. Peppelenbosch,et al.  Signaling Size: Ankyrin and SOCS Box-Containing ASB E3 Ligases in Action. , 2019, Trends in biochemical sciences.

[660]  Limei Liu,et al.  LSD1 Stimulates Cancer-Associated Fibroblasts to Drive Notch3-Dependent Self-Renewal of Liver Cancer Stem-like Cells. , 2018, Cancer research.

[661]  Weifeng Yu,et al.  Notch signaling pathway dampens tumor-infiltrating CD8+ T cells activity in patients with colorectal carcinoma. , 2018, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

[662]  M. Nimwegen,et al.  The Notch Pathway Inhibitor SAHM1 Abrogates the Hallmarks of Allergic Asthma , 2018 .

[663]  F. Faraci,et al.  Increased Notch3 Activity Mediates Pathological Changes in Structure of Cerebral Arteries , 2017, Hypertension.

[664]  K. Luo,et al.  Signaling Cross Talk between TGF-β/Smad and Other Signaling Pathways. , 2017, Cold Spring Harbor perspectives in biology.

[665]  C. Rudin,et al.  Rovalpituzumab tesirine , a DLL 3-targeted antibody-drug conjugate , in recurrent small-cell lung cancer : a fi rst-inhuman , fi rst-in-class , open-label , phase 1 study , 2016 .

[666]  S. Conner,et al.  Regulation of Notch Signaling Through Intracellular Transport. , 2016, International review of cell and molecular biology.

[667]  Mustafa Saad,et al.  Implications for Therapy , 2016 .

[668]  D. Ornitz,et al.  Development of the endochondral skeleton. , 2013, Cold Spring Harbor perspectives in biology.

[669]  V. Deshpande,et al.  Heterogeneity in signaling pathways of gastroenteropancreatic neuroendocrine tumors: a critical look at notch signaling pathway , 2013, Modern Pathology.

[670]  M. Vooijs,et al.  The role of Adams in Notch signaling. , 2012, Advances in experimental medicine and biology.

[671]  H. Kok,et al.  Left ventricular non-compaction cardiomyopathy. , 2012, JBR-BTR : organe de la Societe royale belge de radiologie (SRBR) = orgaan van de Koninklijke Belgische Vereniging voor Radiologie.

[672]  J. L. de la Pompa,et al.  Notch signaling in cardiac development and disease. , 2010, Current topics in developmental biology.

[673]  P. Stanley,et al.  Roles of glycosylation in Notch signaling. , 2010, Current topics in developmental biology.

[674]  Jonathan A. Epstein,et al.  The multifaceted role of Notch in cardiac development and disease , 2008, Nature Reviews Genetics.

[675]  F. Radtke,et al.  Notch and cancer: a double-edged sword , 2008, Cellular and Molecular Life Sciences.

[676]  Masafumi Nakamura,et al.  Gamma-secretase inhibitors enhance taxane-induced mitotic arrest and apoptosis in colon cancer cells. , 2008, Gastroenterology.

[677]  K. Nakao,et al.  Notch/Rbp-j signaling prevents premature endocrine and ductal cell differentiation in the pancreas. , 2006, Cell metabolism.

[678]  D. Sillence,et al.  Mutation of the LUNATIC FRINGE gene in humans causes spondylocostal dysostosis with a severe vertebral phenotype. , 2006, American journal of human genetics.

[679]  A. Joutel,et al.  Autosomal Dominant Leukoencephalopathy and Subcortical Ischemic Stroke , 2005 .

[680]  Frank McCormick,et al.  Notch promotes epithelial-mesenchymal transition during cardiac development and oncogenic transformation. , 2004, Genes & development.

[681]  O. Pourquié,et al.  Vertebrate somitogenesis. , 2001, Annual review of cell and developmental biology.

[682]  Ryoichiro Kageyama,et al.  Control of endodermal endocrine development by Hes-1 , 2000, Nature Genetics.

[683]  A. Nadin,et al.  Photoactivated gamma-secretase inhibitors directed to the active site covalently label presenilin 1. , 2000, Nature.