Hepatic expression of malonyl-CoA decarboxylase reverses muscle, liver and whole-animal insulin resistance

[1]  D. L. Norwood,et al.  Tandem mass spectrometry: A new method for acylcarnitine profiling with potential for neonatal screening for inborn errors of metabolism , 1990, Journal of Inherited Metabolic Disease.

[2]  J. Grippo,et al.  Rapid translocation of hepatic glucokinase in response to intraduodenal glucose infusion and changes in plasma glucose and insulin in conscious rats. , 2004, American journal of physiology. Gastrointestinal and liver physiology.

[3]  S. Wakil,et al.  Acetyl-CoA carboxylase 2 mutant mice are protected against obesity and diabetes induced by high-fat/high-carbohydrate diets , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[4]  A. Butte,et al.  Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1 , 2003, Proceedings of the National Academy of Sciences of the United States of America.

[5]  Douglas L. Rothman,et al.  Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance , 2003, Science.

[6]  G. Shulman,et al.  Mechanism by Which Fatty Acids Inhibit Insulin Activation of Insulin Receptor Substrate-1 (IRS-1)-associated Phosphatidylinositol 3-Kinase Activity in Muscle* , 2002, The Journal of Biological Chemistry.

[7]  W. Kraus,et al.  Fatty Acid Homeostasis and Induction of Lipid Regulatory Genes in Skeletal Muscles of Peroxisome Proliferator-activated Receptor (PPAR) α Knock-out Mice , 2002, The Journal of Biological Chemistry.

[8]  Vincent Lebon,et al.  The effects of rosiglitazone on insulin sensitivity, lipolysis, and hepatic and skeletal muscle triglyceride content in patients with type 2 diabetes. , 2002, Diabetes.

[9]  M. White,et al.  Phosphorylation of Ser307 in Insulin Receptor Substrate-1 Blocks Interactions with the Insulin Receptor and Inhibits Insulin Action* , 2002, The Journal of Biological Chemistry.

[10]  J. McGarry Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. , 2002, Diabetes.

[11]  R. Unger,et al.  Lipotoxic diseases. , 2002, Annual review of medicine.

[12]  A. Srivastava,et al.  Chronic exposure to beta-hydroxybutyrate impairs insulin action in primary cultures of adult cardiomyocytes. , 2001, American journal of physiology. Endocrinology and metabolism.

[13]  G. Reach,et al.  PPAR-α–Null Mice Are Protected From High-Fat Diet–Induced Insulin Resistance , 2001 .

[14]  Simon C Watkins,et al.  Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. , 2001, The Journal of clinical endocrinology and metabolism.

[15]  Michael Karin,et al.  Reversal of Obesity- and Diet-Induced Insulin Resistance with Salicylates or Targeted Disruption of Ikkβ , 2001, Science.

[16]  C. Semenkovich,et al.  PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. , 2001, The Journal of clinical investigation.

[17]  Martin M. Matzuk,et al.  Continuous Fatty Acid Oxidation and Reduced Fat Storage in Mice Lacking Acetyl-CoA Carboxylase 2 , 2001, Science.

[18]  H. Mulder,et al.  Overexpression of a Modified Human Malonyl-CoA Decarboxylase Blocks the Glucose-induced Increase in Malonyl-CoA Level but Has No Impact on Insulin Secretion in INS-1-derived (832/13) β-Cells* , 2001, The Journal of Biological Chemistry.

[19]  G. Shulman,et al.  Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver , 2001, Nature.

[20]  J. Friedman,et al.  Decreased Akt kinase activity and insulin resistance in C57BL/KsJ-Leprdb/db mice. , 2000, The Journal of endocrinology.

[21]  G. Shulman,et al.  Mechanism of Insulin Resistance in A-ZIP/F-1 Fatless Mice* , 2000, The Journal of Biological Chemistry.

[22]  C. Newgard,et al.  Correction of diet-induced hyperglycemia, hyperinsulinemia, and skeletal muscle insulin resistance by moderate hyperleptinemia. , 2000, American journal of physiology. Endocrinology and metabolism.

[23]  S. Chirala,et al.  The subcellular localization of acetyl-CoA carboxylase 2. , 2000, Proceedings of the National Academy of Sciences of the United States of America.

[24]  G. Shulman,et al.  On Diabetes: Insulin Resistance Cellular Mechanisms of Insulin Resistance , 2022 .

[25]  C. Newgard,et al.  Metabolic impact of glucokinase overexpression in liver: lowering of blood glucose in fed rats is accompanied by hyperlipidemia. , 1999, Diabetes.

[26]  L. Orci,et al.  Troglitazone prevents mitochondrial alterations, beta cell destruction, and diabetes in obese prediabetic rats. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[27]  M. Birnbaum,et al.  Differentiation-dependent Suppression of Platelet-derived Growth Factor Signaling in Cultured Adipocytes* , 1999, The Journal of Biological Chemistry.

[28]  D. Kelly,et al.  A critical role for the peroxisome proliferator-activated receptor alpha (PPARalpha) in the cellular fasting response: the PPARalpha-null mouse as a model of fatty acid oxidation disorders. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[29]  Leone,et al.  A critical role for the peroxisome proliferator-activated receptor a (PPAR a ) in the cellular fasting response: The PPAR a -null mouse as a model of fatty acid oxidation disorders , 1999 .

[30]  M. Prentki,et al.  Molecular or Pharmacologic Perturbation of the Link between Glucose and Lipid Metabolism Is without Effect on Glucose-stimulated Insulin Secretion , 1998, The Journal of Biological Chemistry.

[31]  R. Unger,et al.  Increased Lipogenic Capacity of the Islets of Obese Rats: A Role in the Pathogenesis of NIDDM , 1997, Diabetes.

[32]  Jorge Ortiz,et al.  Molecular cloning and tissue expression of human mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase. , 1995, Archives of biochemistry and biophysics.

[33]  J. H. Johnson,et al.  Pancreatic beta-cells in obesity. Evidence for induction of functional, morphologic, and metabolic abnormalities by increased long chain fatty acids. , 1995, The Journal of biological chemistry.

[34]  C. Newgard,et al.  Use of recombinant adenovirus for metabolic engineering of mammalian cells. , 1994, Methods in cell biology.

[35]  R. Gerard,et al.  Adenovirus-mediated transfer of low density lipoprotein receptor gene acutely accelerates cholesterol clearance in normal mice. , 1993, Proceedings of the National Academy of Sciences of the United States of America.

[36]  B. Singh,et al.  Insulin resistance in the regulation of lipolysis and ketone body metabolism in non-insulin dependent diabetes is apparent at very low insulin concentrations. , 1993, Diabetes research and clinical practice.

[37]  H. Taegtmeyer,et al.  Coenzyme A sequestration in rat hearts oxidizing ketone bodies. , 1992, The Journal of clinical investigation.

[38]  M. Holness,et al.  Glucose disposal by skeletal muscle in response to re-feeding after progressive starvation. , 1991, The Biochemical journal.

[39]  H. Taegtmeyer,et al.  Changes in citric acid cycle flux and anaplerosis antedate the functional decline in isolated rat hearts utilizing acetoacetate. , 1991, The Journal of clinical investigation.

[40]  J. McGarry,et al.  New insights into the mitochondrial carnitine palmitoyltransferase enzyme system. , 1991, Biochimie.

[41]  E R Weibel,et al.  Endurance training in humans: aerobic capacity and structure of skeletal muscle. , 1985, Journal of applied physiology.

[42]  C. Newgard,et al.  Efficient hepatic glycogen synthesis in refeeding rats requires continued carbon flow through the gluconeogenic pathway. , 1984, The Journal of biological chemistry.

[43]  J. McGarry,et al.  Hepatic malonyl-CoA levels of fed, fasted and diabetic rats as measured using a simple radioisotopic assay. , 1978, The Journal of biological chemistry.

[44]  J. Massagué,et al.  Insulin control of rat hepatocyte glycogen synthase and phosphorylase in the absence of glucose , 1977, FEBS letters.

[45]  N. Ruderman,et al.  Effect of starvation on muscle glucose metabolism: studies with the isolated perfused rat hindquarter. , 1977, Federation proceedings.

[46]  E. Newsholme,et al.  Regulation of glucose uptake by muscle. 8. Effects of fatty acids, ketone bodies and pyruvate, and of alloxan-diabetes and starvation, on the uptake and metabolic fate of glucose in rat heart and diaphragm muscles. , 1964, The Biochemical journal.

[47]  P. J. Randle,et al.  Regulation of Glucose Uptake by Muscle , 1962 .