Docosatetraenoic acid in endothelial cells: formation, retroconversion to arachidonic acid, and effect on prostacyclin production.

[1]  N. McLaughlin,et al.  Prostacyclin synthesis and deacylation of phospholipids in human endothelial cells: comparison of thrombin, histamine and ionophore A23187. , 1985, Thrombosis research.

[2]  L. Horrocks,et al.  Metabolism of 7,10,13,16-docosatetraenoic acid to dihomo-thromboxane, 14-hydroxy-7,10,12-nonadecatrienoic acid and hydroxy fatty acids by human platelets. , 1985, Biochimica et biophysica acta.

[3]  Waku Keizo,et al.  Enhanced turnover of arachidonic acid-containing species of phosphatidylinositol and phosphatidic acid of concanavalin astimulated lymphocytes , 1984 .

[4]  Y. Nishizuka.  Turnover of inositol phospholipids and signal transduction. , 1984, Science.

[5]  A. A. Spector,et al.  Comparative utilization of n-3 polyunsaturated fatty acids by cultured human Y-79 retinoblastoma cells. , 1984, Biochimica et biophysica acta.

[6]  J. M. Thomas,et al.  Phosphatidylcholine is the major phospholipid providing arachidonic acid for prostacyclin synthesis in thrombin-stimulated human endothelial cells. , 1984, Thrombosis research.

[7]  J. Hoak,et al.  Eicosapentaenoic acid and prostacyclin production by cultured human endothelial cells. , 1983, Journal of lipid research.

[8]  A. A. Spector,et al.  A rapid, isocratic method for phospholipid separation by high-performance liquid chromatography. , 1983, Journal of Lipid Research.

[9]  J. Clarke,et al.  Studies on the turnover of endogenous choline-containing phospholipids of cultured neuroblastoma cells. , 1983, Biochimica et biophysica acta.

[10]  A. A. Spector,et al.  Arachidonic Acid Availability and Prostacyclin Production by Cultured Human Endothelial Cells , 1983, Arteriosclerosis.

[11]  M. Whitehurst,et al.  Fatty acyl Δ6 desaturation activity of cultured human endothelial cells modulation by fetal bovine serum , 1983 .

[12]  K. Waku,et al.  Distinctive selectivity for docosatetraenoic acid incorporation by Ehrlich ascites tumor cells. , 1982, Biochimica et biophysica acta.

[13]  Nakagawa Yasuhito,et al.  Changes in the composition of fatty chains of diacyl, alkylacyl and alkenylacyl ethanolamine and choline phosphoglycerides during the development of chick heart ventricular cells High accumulation of 22.carbon fatty acid in ether phospholipids , 1982 .

[14]  A. A. Spector,et al.  Linoleic Acid Metabolism and Prostaglandin Production by Cultured Bovine Pulmonary Artery Endothelial Cells , 1982, Arteriosclerosis.

[15]  D. Deykin,et al.  Activation of phospholipases A2 and C in pig aortic endothelial cells synthesizing prostacyclin. , 1982, The Journal of biological chemistry.

[16]  S. Moncada.  Prostacyclin and arterial wall biology. , 1982, Arteriosclerosis.

[17]  P. Needleman,et al.  Dihomo-prostaglandins and -thromboxane. A prostaglandin family from adrenic acid that may be preferentially synthesized in the kidney. , 1982, The Journal of biological chemistry.

[18]  J. Hoak,et al.  Comparative effect of ibuprofen on endothelial and platelet prostaglandin synthesis. , 1981, The Journal of pharmacology and experimental therapeutics.

[19]  A. A. Spector,et al.  Utilization of arachidonic and linoleic acids by cultured human endothelial cells. , 1981, The Journal of clinical investigation.

[20]  A. Marcus,et al.  Fatty acid composition of phosphatidylinositol and phosphatidic acid in stimulated platelets. Persistence of arachidonyl-stearyl structure. , 1981, The Journal of biological chemistry.

[21]  C. Jafvert,et al.  Prostacyclin release from cultured and ex vivo bovine vascular endothelium. Studies with thrombin, arachidonic acid, and ionophore A23187. , 1981, Laboratory investigation; a journal of technical methods and pathology.

[22]  F. ten Hoor,et al.  Fish oil feeding lowers thromboxane- and prostacyclin production by rat platelets and aorta and does not result in the formation of prostaglandin I3. , 1981, Prostaglandins.

[23]  A. A. Spector,et al.  Effect of fatty acid modification on prostacyclin production by cultured human endothelial cells. , 1980, The Journal of clinical investigation.

[24]  P. Majerus,et al.  Thrombin-induced hydrolysis of phosphatidylinositol in human platelets. , 1980, The Journal of biological chemistry.

[25]  P. Baer,et al.  Adrenic acid inhibits prostaglandin syntheses. , 1980, Life sciences.

[26]  B. Scherer,et al.  PLATELET-MEMBRANE FATTY ACIDS, PLATELET AGGREGATION, AND THROMBOXANE FORMATION DURING A MACKEREL DIET , 1980, The Lancet.

[27]  C. R. Treadwell,et al.  Essential fatty acid deficiency and adrenal cortical function in vitro. , 1979, Journal of lipid research.

[28]  A. Marcus,et al.  Enzymatic conversion of prostaglandin endoperoxide H2 and arachidonic acid to prostacyclin by cultured human endothelial cells. , 1978, The Journal of biological chemistry.

[29]  J. Vane,et al.  An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation , 1976, Nature.

[30]  V. Ziboh.  Biosynthesis of prostaglandin E 2 in human skin: subcellular localization and inhibition by unsaturated fatty acids and anti-inflammatory drugs. , 1973, Journal of lipid research.

[31]  M. Lees,et al.  Modification of the Lowry procedure for the analysis of proteolipid protein. , 1972, Analytical biochemistry.

[32]  R. Bridges,et al.  The metabolism of 4,7,10,13,16-(5-14C)docosapentaenoic acid in the testis of the rat. , 1970, Biochimica et biophysica acta.

[33]  J. Gellerman,et al.  Retroconversion of docosahexaenoic acid in the rat. , 1969, Biochimica et biophysica acta.

[34]  C. Pace-Asciak,et al.  Inhibition of prostaglandin synthesis by oleic, linoleic and linolenic acids. , 1968, Biochimica et biophysica acta.

[35]  D. Steinberg,et al.  Turnover and utilization of esterified fatty acids in Ehrlich ascites tumor cells. , 1967, The Journal of biological chemistry.

[36]  J. Gellerman,et al.  Retroconversion of polyunsaturated fatty acids in vivo by partial degradation and hydrogenation. , 1967, Biochimica et biophysica acta.

[37]  W. R. Morrison,et al.  PREPARATION OF FATTY ACID METHYL ESTERS AND DIMETHYLACETALS FROM LIPIDS WITH BORON FLUORIDE--METHANOL. , 1964, Journal of lipid research.

[38]  J. Folch,et al.  A simple method for the isolation and purification of total lipides from animal tissues. , 1957, The Journal of biological chemistry.

[39]  R. Magendie,et al.  History of a Case of Hydrophobia, treated at the Hotel Dieu at Paris, by an injection of water into the veins. , 1823 .

[40]  J. Goldsmith,et al.  Interactions of insulin with bovine endothelium. , 1982, Metabolism: clinical and experimental.

[41]  G. Milo,et al.  Effect of exogenous adrenic acid on the proliferation and lipid metabolism of cells in tissue culture. , 1981, Progress in lipid research.

[42]  G. Milo,et al.  Polyunsaturated fatty acid accumulation in the lipids of cultured fibroblasts and smooth muscle cells. , 1981, Journal of lipid research.

[43]  P. Needleman,et al.  Fatty acids as sources of potential "magic bullets" for the modification of platelet and vascular function. , 1981, Progress in lipid research.

[44]  P. Needleman,et al.  Manipulation of platelet aggregation by prostaglandins and their fatty acid precursors: pharmacological basis for a therapeutic approach. , 1980, Prostaglandins.

[45]  J. Hoak,et al.  Use of a radioimmunoassay to study thrombin-induced release of PGI2 from cultured endothelium. , 1979, Thrombosis research.

[46]  R. Philp,et al.  Effect of three nonsteroidal anti-inflammatory agents on platelet function and prostaglandin synthesis in vitro. , 1978, Thrombosis research.

[47]  W. Stoffel,et al.  Enzymatic studies on the mechanism of the retroconversion of C22-polyenoic fatty acids to their C20-homologues. , 1970, Hoppe-Seyler's Zeitschrift fur physiologische Chemie.

[48]  S. Colowick,et al.  Methods in Enzymology , Vol , 1966 .