Avian-origin influenza A(H7N9) infection in influenza A(H7N9)-affected areas of China: a serological study.

Serological surveillance conducted in areas of an outbreak of influenza A(H7N9) infection in China found no seropositivity for antibodies specific for avian-origin influenza A(H7N9) among 1129 individuals of the general population, whereas >6% of 396 poultry workers were positive (on the basis of a hemagglutination inhibition titer of ≥ 80) for this subtype, confirming that infected poultry is the principal source of human infections and that subclinical infections are possible. Fourteen days after symptom onset, elevated levels of antibodies to A(H7N9) were found in 65.8% of patients (25/38) who survived but in only 28.6% of those (2/7) who died, suggesting that the presence of antibodies may improve clinical outcome in infected patients.

[1]  K. Yuen,et al.  Hyperimmune IV immunoglobulin treatment: a multicenter double-blind randomized controlled trial for patients with severe 2009 influenza A(H1N1) infection. , 2013, Chest.

[2]  Dayan Wang,et al.  Monitoring Avian Influenza A(H7N9) Virus through National Influenza-like Illness Surveillance, China , 2013, Emerging infectious diseases.

[3]  Y. Shu,et al.  Serologic study for influenza A (H7N9) among high-risk groups in China. , 2013, The New England journal of medicine.

[4]  Yu Wang,et al.  Origin and diversity of novel avian influenza A H7N9 viruses causing human infection: phylogenetic, structural, and coalescent analyses , 2013, The Lancet.

[5]  J. Farrar,et al.  Population-Level Antibody Estimates to Novel Influenza A/H7N9 , 2013, The Journal of infectious diseases.

[6]  Jie Dong,et al.  Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus. , 2018 .

[7]  Pi-Han Lin,et al.  The first case of H7N9 influenza in Taiwan , 2013, The Lancet.

[8]  Wenjun Song,et al.  Human infections with the emerging avian influenza A H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome , 2013, The Lancet.

[9]  Tian Bai,et al.  Preliminary Report: Epidemiology of the Avian Influenza A (H7N9) Outbreak in China , 2013 .

[10]  Wu Hai-bo,et al.  Sequence and phylogenetic analysis of H7N3 avian influenza viruses isolated from poultry in China in 2011 , 2012, Archives of Virology.

[11]  K. To,et al.  High Titer and Avidity of Nonneutralizing Antibodies against Influenza Vaccine Antigen Are Associated with Severe Influenza , 2012, Clinical and Vaccine Immunology.

[12]  P. Palese,et al.  Seroevidence for H5N1 Influenza Infections in Humans: Meta-Analysis , 2012, Science.

[13]  K. To,et al.  High Incidence of Severe Influenza among Individuals over 50 Years of Age , 2011, Clinical and Vaccine Immunology.

[14]  Gavin J. D. Smith,et al.  Antigenic Profile of Avian H5N1 Viruses in Asia from 2002 to 2007 , 2007, Journal of Virology.

[15]  Maria Zambon,et al.  Serological analysis of serum samples from humans exposed to avian H7 influenza viruses in Italy between 1999 and 2003. , 2005, The Journal of infectious diseases.