Inhibition-Related ERP Components: Variation with Modality, Age, and Time-on-Task

Abstract In Go/Nogo tasks, the ERP after Nogo stimuli generally reveals a negativity (Nogo-)N2 and a subsequent positivity (Nogo-)P3 over fronto-central scalp regions. These components are probably related to different subprocesses serving response inhibition, namely, modality-specific and general inhibition, respectively. In the present study we investigate whether aging or prolonged work (“time-on-task”) have an effect on N2 and P3. Twelve young and 12 elderly subjects performed simple Go/Nogo tasks to visual or auditory letter stimuli. Reaction times were longer after visual than after auditory stimuli, and longer in the elderly than in the young. The ERP results reveal a slight impairment of modality-specific inhibition (N2) in the elderly after visual, but not after auditory, stimuli. General inhibition (P3) was delayed in the elderly for both modalities, as was Go-P3 and RT. Hence, it appears that the response slowing of the elderly is the result of a slowing of the decision process whether to respo...

[1]  A. Fallgatter,et al.  Three-dimensional tomography of event-related potentials during response inhibition: evidence for phasic frontal lobe activation. , 1998, Electroencephalography and clinical neurophysiology.

[2]  C Andrew,et al.  Motor response suppression and the prepotent tendency to respond: a parametric fMRI study , 2000, Neuropsychologia.

[3]  J. Rothwell,et al.  Cortical potentials related to the nogo decision , 2000, Experimental Brain Research.

[4]  W. Dixon,et al.  BMDP statistical software , 1983 .

[5]  J. Polich,et al.  EEG and ERP assessment of normal aging. , 1997, Electroencephalography and clinical neurophysiology.

[6]  H. Bokura,et al.  Electrophysiological correlates for response inhibition in a Go/NoGo task , 2001, Clinical Neurophysiology.

[7]  P Berg,et al.  A multiple source approach to the correction of eye artifacts. , 1994, Electroencephalography and clinical neurophysiology.

[8]  A Pfefferbaum,et al.  ERPs to stimuli requiring response production and inhibition: effects of age, probability and visual noise. , 1988, Electroencephalography and clinical neurophysiology.

[9]  A. Kok.  Effects of degradation of visual stimuli on components of the event-related potential (ERP) in go/nogo reaction tasks , 1986, Biological Psychology.

[10]  J. Hohnsbein,et al.  Effects of choice complexity on different subcomponents of the late positive complex of the event-related potential. , 1994, Electroencephalography and clinical neurophysiology.

[11]  A. Fallgatter,et al.  Age-related changes in the brain electrical correlates of response control , 1999, Clinical Neurophysiology.

[12]  G D Logan,et al.  Strategies and mechanisms in nonselective and selective inhibitory motor control. , 1995, Journal of experimental psychology. Human perception and performance.

[13]  E. Schröger.  Event-related potentials to auditory stimuli following transient shifts of spatial attention in a Go/Nogo task , 1993, Biological Psychology.

[14]  A S Gevins,et al.  Effects of prolonged mental work on functional brain topography. , 1990, Electroencephalography and clinical neurophysiology.

[15]  J. Ford,et al.  ERPs to response production and inhibition. , 1985, Electroencephalography and clinical neurophysiology.

[16]  A Kok,et al.  Effects of task complexity in young and old adults: reaction time and P300 latency are not always dissociated. , 1999, Psychophysiology.

[17]  B. Kopp,et al.  N2, P3 and the lateralized readiness potential in a nogo task involving selective response priming. , 1996, Electroencephalography and clinical neurophysiology.

[18]  E. Donchin,et al.  On quantifying surprise: the variation of event-related potentials with subjective probability. , 1977, Psychophysiology.

[19]  E. Stein,et al.  Right hemispheric dominance of inhibitory control: an event-related functional MRI study. , 1999, Proceedings of the National Academy of Sciences of the United States of America.

[20]  K. R. Ridderinkhof,et al.  Mental resources, processing speed, and inhibitory control: a developmental perspective , 1997, Biological Psychology.

[21]  David L. Strayer,et al.  Aging and inhibition: beyond a unitary view of inhibitory processing in attention. , 1994, Psychology and aging.

[22]  P. Michie,et al.  ERP correlates of response inhibition to elemental and configural stimuli in a negative patterning task , 2000, Clinical Neurophysiology.

[23]  D. Lehmann,et al.  Low resolution electromagnetic tomography: a new method for localizing electrical activity in the brain. , 1994, International journal of psychophysiology : official journal of the International Organization of Psychophysiology.

[24]  E. Jodo,et al.  Relation of a negative ERP component to response inhibition in a Go/No-go task. , 1992, Electroencephalography and clinical neurophysiology.

[25]  K. Kiehl,et al.  Event‐related fMRI study of response inhibition , 2001, Human brain mapping.

[26]  J. Hohnsbein,et al.  ERP components in Go/Nogo tasks and their relation to inhibition. , 1999, Acta psychologica.

[27]  M Spitzer,et al.  The time course of brain activations during response inhibition: evidence from event‐related potentials in a go/no go task , 1998, Neuroreport.

[28]  Martin Eimer,et al.  Effects of attention and stimulus probability on ERPs in a Go/Nogo task , 1993, Biological Psychology.

[29]  Y. Miyashita,et al.  Common inhibitory mechanism in human inferior prefrontal cortex revealed by event-related functional MRI. , 1999, Brain : a journal of neurology.

[30]  N. Birbaumer,et al.  Positive shifts of event-related potentials: a state of cortical disfacilitation as reflected by the startle reflex probe. , 1994, Electroencephalography and clinical neurophysiology.

[31]  F. Duffy,et al.  Significance probability mapping: an aid in the topographic analysis of brain electrical activity. , 1981, Electroencephalography and clinical neurophysiology.

[32]  T W Picton,et al.  The effects of age on human event-related potentials. , 1984, Psychophysiology.

[33]  L. Karlin,et al.  Motor performance and sensory-evoked potentials. , 1970, Electroencephalography and clinical neurophysiology.

[34]  J. Hohnsbein,et al.  Late ERP components in visual and auditory Go/Nogo tasks. , 1995, Electroencephalography and clinical neurophysiology.

[35]  N Birbaumer,et al.  Mapping P300 waves onto inhibition: Go/No-Go discrimination. , 1994, Electroencephalography and clinical neurophysiology.