Design, synthesis, and evaluation of new anti-inflammatory natural products amide derivatives endowed with anti-blood cancer activity towards development of potential multifunctional agents against hematological cancers.

[1]  Kyung-Sook Chung,et al.  3',4'-Dihydroxyflavone mitigates inflammatory responses by inhibiting LPS and TLR4/MD2 interaction. , 2022, Phytomedicine : international journal of phytotherapy and phytopharmacology.

[2]  D. Ngo,et al.  Two new dimethylpyranoflavanones from the roots of Melodorum fruticosum. , 2022, Natural product research.

[3]  E. Roh,et al.  Identification of Novel Aryl Carboxamide Derivatives as Death-Associated Protein Kinase 1 (DAPK1) Inhibitors with Anti-Proliferative Activities: Design, Synthesis, In Vitro, and In Silico Biological Studies , 2022, Pharmaceuticals.

[4]  Kyung-Sook Chung,et al.  Mosloflavone-Resveratrol Hybrid TMS-HDMF-5z Exhibits Potent In Vitro and In Vivo Anti-Inflammatory Effects Through NF-κB, AP-1, and JAK/STAT Inactivation , 2022, Frontiers in Pharmacology.

[5]  Ki Duk Park,et al.  Positional scanning of natural product hispidol’s ring-B: discovery of highly selective human monoamine oxidase-B inhibitor analogues downregulating neuroinflammation for management of neurodegenerative diseases , 2022, Journal of enzyme inhibition and medicinal chemistry.

[6]  Jenny C. Chang,et al.  A phase 1/2 clinical trial of the nitric oxide synthase inhibitor L-NMMA and taxane for treating chemoresistant triple-negative breast cancer , 2021, Science Translational Medicine.

[7]  J. Martins,et al.  Analysis of Conformational, Structural, Magnetic, and Electronic Properties Related to Antioxidant Activity: Revisiting Flavan, Anthocyanidin, Flavanone, Flavonol, Isoflavone, Flavone, and Flavan-3-ol , 2021, ACS omega.

[8]  G. Colombo,et al.  Prostaglandin E2 and Cancer: Insight into Tumor Progression and Immunity , 2020, Biology.

[9]  C. Mahidol,et al.  Uvarmicranones A and B, two new benzoquinones and cytotoxic constituents from the stems of Uvaria micrantha (A. DC.) Hook. f. & Thomson , 2020, Natural product research.

[10]  Kyung-Sook Chung,et al.  Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approaches. , 2020, Bioorganic chemistry.

[11]  M. Mercogliano,et al.  Tumor Necrosis Factor α Blockade: An Opportunity to Tackle Breast Cancer , 2020, Frontiers in Oncology.

[12]  M. Libra,et al.  Nitric Oxide in Hematological Cancers: Partner or Rival? , 2020, Antioxidants & redox signaling.

[13]  Yong Sup Lee,et al.  An expeditious entry to rare tetrahydroimidazo[1,5-c]pyrrolo[1,2-a]pyrimidin-7(8H)-ones: A single-step gateway synthesis of glochidine congeners , 2019 .

[14]  Kyung-Tae Lee,et al.  Flavone-based arylamides as potential anticancers: Design, synthesis and in vitro cell-based/cell-free evaluations. , 2019, European journal of medicinal chemistry.

[15]  A. Pae,et al.  Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents. , 2019, European journal of medicinal chemistry.

[16]  Ki Duk Park,et al.  Reprofiling of pyrimidine-based DAPK1/CSF1R dual inhibitors: identification of 2,5-diamino-4-pyrimidinol derivatives as novel potential anticancer lead compounds , 2019, Journal of enzyme inhibition and medicinal chemistry.

[17]  Kyung-Sook Chung,et al.  The Anti-Proliferative Activity of the Hybrid TMS-TMF-4f Compound Against Human Cervical Cancer Involves Apoptosis Mediated by STAT3 Inactivation , 2019, Cancers.

[18]  A. Pae,et al.  Optimization study towards more potent thiazolidine-2,4-dione IKK-β modulator: Synthesis, biological evaluation and in silico docking simulation. , 2019, Bioorganic chemistry.

[19]  Kyung-Tae Lee,et al.  Repurposing mosloflavone/5,6,7-trimethoxyflavone-resveratrol hybrids: Discovery of novel p38-α MAPK inhibitors as potent interceptors of macrophage-dependent production of proinflammatory mediators. , 2019, European journal of medicinal chemistry.

[20]  M. Yousefi,et al.  Prostaglandin E2 as a potent therapeutic target for treatment of colon cancer. , 2019, Prostaglandins & other lipid mediators.

[21]  N. Meyer,et al.  The TNF Paradox in Cancer Progression and Immunotherapy , 2019, Front. Immunol..

[22]  Kyung-Tae Lee,et al.  EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor. , 2019, Bioorganic chemistry.

[23]  Jongki Hong,et al.  Design, synthesis and cytotoxicity of chimeric erlotinib-alkylphospholipid hybrids. , 2019, Bioorganic chemistry.

[24]  B. Han,et al.  The high expression of TNF-α and NF-κB in tumor microenvironment predicts good prognosis of patients with BCLC-0-B hepatocellular carcinoma , 2019, Translational cancer research.

[25]  Ji-Sun Shin,et al.  Natural products hybrids: 3,5,4'-Trimethoxystilbene-5,6,7-trimethoxyflavone chimeric analogs as potential cytotoxic agents against diverse human cancer cells. , 2019, European journal of medicinal chemistry.

[26]  A. Winnicka,et al.  The cyclooxygenase-2/prostaglandin E2 pathway and its role in the pathogenesis of human and dog hematological malignancies. , 2018, Journal of physiology and pharmacology : an official journal of the Polish Physiological Society.

[27]  W. Hur,et al.  Design, synthesis and biological evaluation of novel thiazolidinedione derivatives as irreversible allosteric IKK-β modulators. , 2018, European journal of medicinal chemistry.

[28]  Y. Cho,et al.  Construction of 8-Azabicyclo[3.2.1]octanes via Sequential DDQ-Mediated Oxidative Mannich Reactions of N-Aryl Pyrrolidines. , 2018, Organic letters.

[29]  Yong Sup Lee,et al.  Hit discovery of 4-amino-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide: A novel EGFR inhibitor from a designed small library. , 2017, Bioorganic chemistry.

[30]  P. Nandi,et al.  PGE2 promotes breast cancer-associated lymphangiogenesis by activation of EP4 receptor on lymphatic endothelial cells , 2017, BMC Cancer.

[31]  Y. Iwakura,et al.  Positive feedback between NF-κB and TNF-α promotes leukemia-initiating cell capacity. , 2014, The Journal of clinical investigation.

[32]  A. Gadbail,et al.  Nitric oxide and cancer: a review , 2013, World Journal of Surgical Oncology.

[33]  D. Hanahan,et al.  Hallmarks of Cancer: The Next Generation , 2011, Cell.

[34]  Phil S Baran,et al.  Aiming for the ideal synthesis. , 2010, The Journal of organic chemistry.

[35]  Jason R. Hickok,et al.  Nitric oxide and cancer therapy: the emperor has NO clothes. , 2010, Current pharmaceutical design.

[36]  Heather R. Roberts,et al.  The COX-2/PGE2 pathway: key roles in the hallmarks of cancer and adaptation to the tumour microenvironment. , 2009, Carcinogenesis.

[37]  P. Sime,et al.  Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. , 2008, Current pharmaceutical design.

[38]  F. Balkwill.  TNF-α in promotion and progression of cancer , 2006, Cancer and Metastasis Reviews.

[39]  C. Pham-Huy,et al.  Chiral Drugs: An Overview , 2006, International journal of biomedical science : IJBS.

[40]  M. Backlund,et al.  Mechanisms of Disease: inflammatory mediators and cancer prevention , 2005, Nature Clinical Practice Oncology.

[41]  J. Zapp,et al.  Secondary metabolites from the liverwort Tylimanthus renifolius. , 2003, Phytochemistry.

[42]  Weiming Xu,et al.  The role of nitric oxide in cancer , 2002, Cell Research.

[43]  Alberto Mantovani,et al.  Inflammation and cancer: back to Virchow? , 2001, The Lancet.

[44]  K. Komiyama,et al.  Cytocidal and antimicrobial activities of flavonoids , 1995 .

[45]  Tian-Shung Wu,et al.  Flavanone and other constituents from Onychium siliculosum , 1981 .

[46]  Ji-Young Kim,et al.  Enantiopure methoxetamine stereoisomers: chiral resolution, conformational analysis, UV-circular dichroism spectroscopy and electronic circular dichroism , 2021 .

[47]  Yong Sup Lee,et al.  Design, synthesis and evaluation of alkylphosphocholine-gefitinib conjugates as multitarget anticancer agents , 2018, Archives of pharmacal research.

[48]  Jianfeng Zhou,et al.  Tumor necrosis factor α in the onset and progression of leukemia. , 2017, Experimental hematology.

[49]  H. Achenbach,et al.  Alkaloids, flavonoids and phenylpropanoids of the west African plant Oxymitra velutina , 1991 .

[50]  F. Bohlmann,et al.  Neue chalkon-derivate aus südafrikanischen Helichrysum-arten , 1978 .