Cardiovascular Simulation Toolbox

A toolbox for Matlab Simulink (trademark of Mathworks corp. etc.) was developed to simulate various models of flow in the cardiovascular system and study effects of different pathological conditions. The toolbox was based on well-known analog lumped models of blood flow in vessels, the varying elastance heart model, blood flow through vessels, shunts, and valves as well as models of oxygen exchange at lungs and tissue. The toolbox is modular providing the basic building blocks of the cardiovascular system. Parameters for the individual components may be set by the user to adapt the component to the simulated system. Several examples are shown. This modeling system is described and is also available for downloading as an open source for free use. The authors see this as the basis for wide collaboration and standardization in modeling. A web site will be available for accepting contributions from other researchers and to create a free exchange.

[1]  O Barnea,et al.  Estimation of oxygen delivery in newborns with a univentricular circulation. , 1998, Circulation.

[2]  O. Barnea,et al.  A computer model for analysis of fluid resuscitation. , 1993, Computers in biology and medicine.

[3]  A A Shoukas,et al.  Instantaneous Pressure‐Volume Relationship of the Canine Right Ventricle , 1979, Circulation research.

[4]  Roger D. Kamm,et al.  Model-Based Assessment of Cardiovascular Health from Noninvasive Measurements , 2002, Annals of Biomedical Engineering.

[5]  A D McCulloch,et al.  Regional myocardial mechanics: Integrative computational models of flow-function relations , 2001, Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology.

[6]  H. Suga,et al.  Instantaneous Pressure‐Volume Relationships and Their Ratio in the Excised, Supported Canine Left Ventricle , 1974, Circulation research.

[7]  T. Takishima,et al.  Effects of changes in the aortic input impedance on systolic pressure-ejected volume relationships in the isolated supported canine left ventricle. , 1980, Cardiovascular research.

[8]  A. Rudolph.  Fetal and neonatal pulmonary circulation. , 1977, The American review of respiratory disease.

[9]  C. E. Duffy,et al.  Fetal and neonatal cardiology , 1991 .

[10]  Dov Jaron,et al.  Computer simulation of the mechanically-assisted failing canine circulation , 2006, Annals of Biomedical Engineering.

[11]  R. Beyar,et al.  A Computer Study of the Left Ventricular Performance Based on Fiber Structure, Sarcomere Dynamics, and Transmural Electrical Propagation Velocity , 1984, Circulation research.

[12]  C. H. Chen,et al.  Single-beat estimation of end-systolic pressure-volume relation in humans. A new method with the potential for noninvasive application. , 1996, Circulation.

[13]  Philip L. Altman,et al.  Respiration and Circulation , 1971 .