Treatment of Circadian Rhythm Sleep Disorders with Light

Sleep loss can severely impact on the integrity of cognitive functions. This review highlights the recent functional neuroimaging studies on the brain’s response while performing cognitive tasks when deprived of sleep. Among sleep-deprived healthy volunteers, reduced attention, accompanied by lowered parieto-occipital activation, may underlie performance decrements seen in other “higher cognitive domains”. Functional neuroimaging in this setting has increased our understanding of how the brain responds to, and compensates for, sleep loss. Functional neuroimaging may also provide a safe, reproducible and non-invasive means to evaluate the cognitive and neural impact of therapeutic interventions designed to treat sleep disorders and/ or to reduce the negative cognitive impact of sleep loss. Key words: Attention, Cognition, Functional neuroimaging, Memory, Sleep deprivation

[1]  E. Altena,et al.  Insomnia affects executive functioning: a waitinglist-controlled non-medicated treatment study using fMRI , 2009, NeuroImage.

[2]  Corfield,et al.  Changes in Brain Morphology Associated with Obstructive Sleep Apnea (OSA). , 2009, ATS 2009.

[3]  B Luber,et al.  Cerebral Cortex doi:10.1093/cercor/bhm231 Remediation of Sleep-Deprivation-- Induced Working Memory Impairment with fMRI-Guided Transcranial Magnetic Stimulation , 2008 .

[4]  Lisa Y. M. Chuah,et al.  Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition , 2008, Current opinion in neurology.

[5]  Lisa Y. M. Chuah,et al.  P2-455: The neurocognitive effects of donepezil on visual short-term memory capacity following 24 Hours of sleep deprivation , 2008, Alzheimer's & Dementia.

[6]  S. Schwartz,et al.  Inhibitory motor control in apneic and insomniac patients: a stop task study , 2007, Journal of sleep research.

[7]  Manuel Schabus,et al.  Sleep transforms the cerebral trace of declarative memories , 2007, Proceedings of the National Academy of Sciences.

[8]  L. Ayalon,et al.  Functional central nervous system imaging in the investigation of obstructive sleep apnea , 2007, Current opinion in pulmonary medicine.

[9]  M. Walker,et al.  The human emotional brain without sleep — a prefrontal amygdala disconnect , 2007, Current Biology.

[10]  Manuel Schabus,et al.  Sleep-Related Hippocampo-Cortical Interplay during Emotional Memory Recollection , 2007, PLoS biology.

[11]  S. Drummond,et al.  Discrepancy between subjective symptomatology and objective neuropsychological performance in insomnia. , 2007, Sleep.

[12]  D. Dinges,et al.  Behavioral and physiological consequences of sleep restriction. , 2007, Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine.

[13]  Arnstein Mykletun,et al.  Chronic insomnia as a risk factor for developing anxiety and depression. , 2007, Sleep.

[14]  T. Dang-Vu,et al.  Neuroimaging in sleep medicine. , 2007, Sleep medicine.

[15]  Lisa Y. M. Chuah,et al.  Functional neuroimaging and behavioral correlates of capacity decline in visual short-term memory after sleep deprivation , 2007, Proceedings of the National Academy of Sciences.

[16]  Vinod Venkatraman,et al.  Sleep deprivation elevates expectation of gains and attenuates response to losses following risky decisions. , 2007, Sleep.

[17]  Anne Germain,et al.  Daytime symptoms in primary insomnia: a prospective analysis using ecological momentary assessment. , 2007, Sleep medicine.

[18]  G. Plazzi,et al.  Proton magnetic resonance spectroscopy study of brain metabolism in obstructive sleep apnoea syndrome before and after continuous positive airway pressure treatment. , 2007, Sleep.

[19]  Ronald J Ozminkowski,et al.  The direct and indirect costs of untreated insomnia in adults in the United States. , 2007, Sleep.

[20]  Seung-Schik Yoo,et al.  A deficit in the ability to form new human memories without sleep , 2007, Nature Neuroscience.

[21]  M. Chee,et al.  Reproducibility of changes in behaviour and fMRI activation associated with sleep deprivation in a working memory task. , 2007, Sleep.

[22]  Jan Born,et al.  Impaired Declarative Memory Consolidation During Sleep in Patients With Primary Insomnia: Influence of Sleep Architecture and Nocturnal Cortisol Release , 2006, Biological Psychiatry.

[23]  J. Kornhuber,et al.  Daytime impairment and neurodegeneration in OSAS. , 2006, Sleep.

[24]  R. Thomas,et al.  Modafinil activates cortical and subcortical sites in the sleep-deprived state. , 2006, Sleep.

[25]  J. Born,et al.  Sleep to Remember , 2006, The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry.

[26]  B. Feige,et al.  Impaired sleep-related memory consolidation in primary insomnia--a pilot study. , 2006, Sleep.

[27]  Sean P. A. Drummond,et al.  Increased brain activation during verbal learning in obstructive sleep apnea , 2006, NeuroImage.

[28]  M. Chee,et al.  The Neural Basis of Interindividual Variability in Inhibitory Efficiency after Sleep Deprivation , 2006, The Journal of Neuroscience.

[29]  Michael W. L. Chee,et al.  Functional imaging of working memory following normal sleep and after 24 and 35 h of sleep deprivation: Correlations of fronto-parietal activation with performance , 2006, NeuroImage.

[30]  C. Degueldre,et al.  Sleep after spatial learning promotes covert reorganization of brain activity. , 2006, Proceedings of the National Academy of Sciences of the United States of America.

[31]  E. Nofzinger.  Neuroimaging of sleep and sleep disorders , 2006, Current neurology and neuroscience reports.

[32]  T. Balkin,et al.  Impaired decision making following 49 h of sleep deprivation , 2006, Journal of sleep research.

[33]  Jérôme Dinet,et al.  Insomnia and absenteeism at work. Who pays the cost? , 2006, Sleep.

[34]  M. J. Meloy,et al.  Compensatory recruitment after sleep deprivation and the relationship with performance , 2005, Psychiatry Research: Neuroimaging.

[35]  D. Beebe,et al.  Neurobehavioral effects of obstructive sleep apnea: an overview and heuristic model , 2005, Current opinion in pulmonary medicine.

[36]  T. Ng,et al.  Prevalence and determinants of excessive daytime sleepiness in an Asian multi-ethnic population. , 2005, Sleep medicine.

[37]  T. Balkin,et al.  The use of stimulants to modify performance during sleep loss: a review by the sleep deprivation and Stimulant Task Force of the American Academy of Sleep Medicine. , 2005, Sleep.

[38]  R. Stickgold,et al.  Memory consolidation and reconsolidation: what is the role of sleep? , 2005, Trends in Neurosciences.

[39]  P. Maquet.  Current status of brain imaging in sleep medicine. , 2005, Sleep medicine reviews.

[40]  H. V. Van Dongen.  Analysis of inter‐ and intra‐individual variability , 2005, Journal of sleep research.

[41]  M. George,et al.  Are individual differences in fatigue vulnerability related to baseline differences in cortical activation? , 2005, Behavioral neuroscience.

[42]  E. Nofzinger,et al.  Neuroimaging and sleep medicine. , 2005, Sleep medicine reviews.

[43]  C. Stern,et al.  Functional imaging of working memory in obstructive sleep-disordered breathing. , 2005, Journal of applied physiology.

[44]  Anne Germain,et al.  Focusing on the Experience of Insomnia , 2005, Behavioral sleep medicine.

[45]  D. Dinges,et al.  Individual differences in adult human sleep and wakefulness: Leitmotif for a research agenda. , 2005, Sleep.

[46]  Michael W. L. Chee,et al.  Dissociation of cortical regions modulated by both working memory load and sleep deprivation and by sleep deprivation alone , 2005, NeuroImage.

[47]  Kevin A. Johnson,et al.  Decreased brain activation during a working memory task at rested baseline is associated with vulnerability to sleep deprivation. , 2005, Sleep.

[48]  E. Nofzinger.  Functional neuroimaging of sleep. , 2005, Seminars in neurology.

[49]  G. Kerkhof,et al.  Chronic insomnia and performance in a 24‐h constant routine study , 2005, Journal of sleep research.

[50]  Jejo D. Koola,et al.  Decreased cortical response to verbal working memory following sleep deprivation. , 2005, Sleep.

[51]  D. Dinges,et al.  Neurocognitive Consequences of Sleep Deprivation , 2005, Seminars in neurology.

[52]  A. Papadimitriou,et al.  Frontal brain lobe impairment in obstructive sleep apnoea: a proton MR spectroscopy study , 2004, European Respiratory Journal.

[53]  D. Riemann.  Insomnia: Principles and ManagementEdited by Martin P. Szuba, Jacqueline D. Kloss, and David F. Dinges, Cambridge: Cambridge University Press, 2003. E34.95. 306 pages , 2004 .

[54]  Anne Germain,et al.  Functional neuroimaging evidence for hyperarousal in insomnia. , 2004, The American journal of psychiatry.

[55]  Jennifer D. Davis,et al.  Neuropsychological sequelae of obstructive sleep apnea-hypopnea syndrome: A critical review , 2004, Journal of the International Neuropsychological Society.

[56]  U. Seneviratne,et al.  Excessive daytime sleepiness in obstructive sleep apnea: prevalence, severity, and predictors. , 2004, Sleep medicine.

[57]  S. Drummond,et al.  Functional imaging of the sleeping brain: review of findings and implications for the study of insomnia. , 2004, Sleep medicine reviews.

[58]  M. Chee,et al.  Functional Imaging of Working Memory after 24 Hr of Total Sleep Deprivation , 2004, The Journal of Neuroscience.

[59]  Gregory G. Brown,et al.  Increasing task difficulty facilitates the cerebral compensatory response to total sleep deprivation. , 2004, Sleep.

[60]  Yaakov Stern,et al.  Identification and differential vulnerability of a neural network in sleep deprivation. , 2004, Cerebral cortex.

[61]  E. Zarahn,et al.  An event-related fMRI study of the neurobehavioral impact of sleep deprivation on performance of a delayed-match-to-sample task. , 2004, Brain research. Cognitive brain research.

[62]  Jeffry R Alger,et al.  Brain morphology associated with obstructive sleep apnea. , 2002, American journal of respiratory and critical care medicine.

[63]  Leslie G. Ungerleider,et al.  Neural Correlates of Visual Working Memory fMRI Amplitude Predicts Task Performance , 2002, Neuron.

[64]  T. Young,et al.  Epidemiology of obstructive sleep apnea: a population health perspective. , 2002, American journal of respiratory and critical care medicine.

[65]  Gregory G. Brown,et al.  Increased cerebral response during a divided attention task following sleep deprivation , 2001, Journal of sleep research.

[66]  J. Horne,et al.  Fatigue, alcohol, and serious road crashes in France: factorial study of national data , 2001, BMJ : British Medical Journal.

[67]  Maria L. Thomas,et al.  Neural basis of alertness and cognitive performance impairments during sleepiness. I. Effects of 24 h of sleep deprivation on waking human regional brain activity , 2000, Journal of sleep research.

[68]  Gregory G. Brown,et al.  Altered brain response to verbal learning following sleep deprivation , 2000, Nature.

[69]  Y. Inoue,et al.  Cerebral metabolism in sleep apnea. Evaluation by magnetic resonance spectroscopy. , 1997, American journal of respiratory and critical care medicine.

[70]  M. Buchsbaum,et al.  The effect of sleep deprivation on cerebral glucose metabolic rate in normal humans assessed with positron emission tomography. , 1991, Sleep.

[71]  J. Stern,et al.  Daytime alertness in subjective and objective insomnia: Some preliminary findings , 1985, Biological Psychiatry.

[72]  H. Weingartner,et al.  The experience of insomnia and daytime and nightime functioning , 1984, Psychiatry Research.