Transversal and longitudinal images from the retina of the living eye using low coherence reflectometry.

An optical coherence tomography (OCT) system to produce both longitudinal and transversal images of the in vivo human eye is presented. For the first time, OCT transversal images collected from the living eye at 50-μm depth steps show details unobtainable with the state-of-the-art scanning laser ophthalmoscope. Images of up to 3×3 mm are produced from the retina in less than a second. For images larger than 1.6×1.6 mm, a path modulation is introduced by the galvanometric scanning mirror and is used as an effective phase modulation method.© 1998 Society of Photo-Optical Instrumentation Engineers.

[1]  J. Fujimoto,et al.  In vivo retinal imaging by optical coherence tomography. , 1993, Optics letters.

[2]  B E Bouma,et al.  Rapid acquisition of in vivo biological images by use of optical coherence tomography. , 1996, Optics letters.

[3]  C. Su.  Achieving variation of the optical path length by a few millimeters at millisecond rates for imaging of turbid media and optical interferometry: a new technique. , 1997, Optics letters.

[4]  G. Timberlake,et al.  Optical modifications to a scanner laser ophthalmoscope for high magnification, narrow optical section imaging , 1991 .

[5]  S. Newton,et al.  Characterization of human scalp hairs by optical low-coherence reflectometry. , 1995, Optics letters.

[6]  Adolf Friedrich Fercher,et al.  Measurement of Intraocular Optical Distances Using Partially Coherent Laser Light , 1991 .

[7]  A F Fercher,et al.  Optical coherence tomography. , 1996, Journal of biomedical optics.

[8]  J. Duker,et al.  Imaging of macular diseases with optical coherence tomography. , 1995, Ophthalmology.

[9]  Imaging through animal tissues with CW diode laser based broadband interferometry , 1995 .

[10]  D. Jackson,et al.  Fiberised set-up for eye length measurement , 1997 .

[11]  Harald Sattmann,et al.  Measurement of the thickness of fundus layers by partial coherence tomography , 1995 .

[12]  D. Jackson,et al.  Coherence imaging by use of a Newton rings sampling function. , 1996, Optics letters.

[13]  J. Fujimoto,et al.  Optical Coherence Tomography , 1991 .

[14]  A. Fercher,et al.  Eye-length measurement by interferometry with partially coherent light. , 1988, Optics letters.

[15]  R. P. Novak,et al.  High-resolution reflectometry in biological tissues. , 1992, Optics letters.

[16]  Barry R. Masters,et al.  Noninvasive Diagnostic Techniques in Ophthalmology , 1990, Springer New York.

[17]  K. Yukimatsu,et al.  Phase-noise and shot-noise limited operations of low coherence optical time domain reflectometry , 1991 .

[18]  Robert H. Webb,et al.  Scanning Laser Ophthalmoscope , 1981, IEEE Transactions on Biomedical Engineering.

[19]  J G Fujimoto,et al.  High-resolution optical coherence tomographic imaging using a mode-locked Ti:Al(2)O(3) laser source. , 1995, Optics letters.

[20]  D. Jackson,et al.  Simultaneous en-face imaging of two layers in the human retina by low-coherence reflectometry. , 1997, Optics letters.