A novel neuronal cell protecting substance, aestivophoenin C, produced by Streptomyces purpeofuscus.

The excitatory neurotransmitter, L-glutamate plays a critical role in the neuronal injury that results from cerebral ischemia or head trauma. Following either of these insults the concentration of extracellular L-glutamate is elevated, and then this event induces many processes including an increase in intracellular Ca2+ concentration, hyperkalemia, activation of proteases, synthesis of nitric oxide and production of reactive

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