An APOBEC3A-Cas9 base editor with minimized bystander and off-target activities
暂无分享,去创建一个
Luca Pinello | Jason M. Gehrke | Daniel E Bauer | J Keith Joung | Yuxuan Wu | J. Joung | D. E. Bauer | Yuxuan Wu | Jing Zeng | Jing Zeng | Jason M Gehrke | Oliver Cervantes | M Kendell Clement | M. K. Clement | Luca Pinello | O. Cervantes
[1] Rommie E. Amaro,et al. Structural basis for targeted DNA cytosine deamination and mutagenesis by APOBEC3A and APOBEC3B , 2016, Nature Structural &Molecular Biology.
[2] Bei Yang,et al. Enhanced base editing by co-expression of free uracil DNA glycosylase inhibitor , 2017, Cell Research.
[3] Jaewoong Hwang,et al. Rescue of high-specificity Cas9 variants using sgRNAs with matched 5’ nucleotides , 2017, Genome Biology.
[4] B. Eng,et al. Three New β-Globin Gene Promoter Mutations Identified Through Newborn Screening , 2007 .
[5] Zhi Zhang,et al. A Novel Promoter Mutation (HBB: c.-75G>T) Was Identified as a Cause of β+-Thalassemia , 2015, Hemoglobin.
[6] Rommie E. Amaro,et al. The local dinucleotide preference of APOBEC3G can be altered from 5'-CC to 5'-TC by a single amino acid substitution. , 2013, Journal of molecular biology.
[7] A. Kondo,et al. Targeted nucleotide editing using hybrid prokaryotic and vertebrate adaptive immune systems , 2016, Science.
[8] David R. Liu,et al. Evolved Cas9 variants with broad PAM compatibility and high DNA specificity , 2018, Nature.
[9] S. Hubbard,et al. A DNA Sequence Recognition Loop on APOBEC3A Controls Substrate Specificity , 2014, PloS one.
[10] Kevin T. Zhao,et al. Increasing the genome-targeting scope and precision of base editing with engineered Cas9-cytidine deaminase fusions , 2017, Nature Biotechnology.
[11] Kevin T. Zhao,et al. Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity , 2017, Science Advances.
[12] C. Schiffer,et al. The ssDNA Mutator APOBEC3A Is Regulated by Cooperative Dimerization. , 2015, Structure.
[13] Akihiko Kondo,et al. Targeted base editing in rice and tomato using a CRISPR-Cas9 cytidine deaminase fusion , 2017, Nature Biotechnology.
[14] Jeffry D. Sander,et al. CRISPR-Cas systems for editing, regulating and targeting genomes , 2014, Nature Biotechnology.
[15] David R. Liu,et al. Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery , 2017, Nature Communications.
[16] David A. Scott,et al. In vivo genome editing using Staphylococcus aureus Cas9 , 2015, Nature.
[17] Jennifer A. Doudna,et al. Enhanced proofreading governs CRISPR-Cas9 targeting accuracy , 2017, Nature.
[18] Jin-Soo Kim,et al. Cas-OFFinder: a fast and versatile algorithm that searches for potential off-target sites of Cas9 RNA-guided endonucleases , 2014, Bioinform..
[19] Daesik Kim,et al. Highly efficient RNA-guided base editing in mouse embryos , 2017, Nature Biotechnology.
[20] Dan Liu,et al. Correction of β-thalassemia mutant by base editor in human embryos , 2017, Protein & Cell.
[21] Matthew C. Canver,et al. Analyzing CRISPR genome-editing experiments with CRISPResso , 2016, Nature Biotechnology.
[22] Gaelen T. Hess,et al. Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells , 2016, Nature Methods.
[23] M. Wang,et al. AID up-mutants isolated using a high-throughput screen highlight the immunity/cancer balance limiting DNA deaminase activity , 2009, Nature Structural &Molecular Biology.
[24] C. Schiffer,et al. Crystal structure of APOBEC3A bound to single-stranded DNA reveals structural basis for cytidine deamination and specificity , 2017, Nature Communications.
[25] E. Welker,et al. Crossing enhanced and high fidelity SpCas9 nucleases to optimize specificity and cleavage , 2017, Genome Biology.
[26] Randall J. Platt,et al. Therapeutic genome editing: prospects and challenges , 2015, Nature Medicine.
[27] J. Doudna,et al. The new frontier of genome engineering with CRISPR-Cas9 , 2014, Science.
[28] J. Keith Joung,et al. 731. High-Fidelity CRISPR-Cas9 Nucleases with No Detectable Genome-Wide Off-Target Effects , 2016 .
[29] B. Eng,et al. Three new beta-globin gene promoter mutations identified through newborn screening. , 2007, Hemoglobin.
[30] David R. Liu,et al. Programmable editing of a target base in genomic DNA without double-stranded DNA cleavage , 2016, Nature.
[31] Daesik Kim,et al. Genome-wide target specificities of CRISPR RNA-guided programmable deaminases , 2017, Nature Biotechnology.
[32] J F Glenn,et al. Prospects and challenges. , 1967, The Journal of urology.
[33] Yuting Tan,et al. Genome editing using CRISPR-Cas9 to create the HPFH genotype in HSPCs: An approach for treating sickle cell disease and β-thalassemia , 2016, Proceedings of the National Academy of Sciences.
[34] J. Joung,et al. High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets , 2015, Nature.
[35] Martin J. Aryee,et al. GUIDE-Seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases , 2014, Nature Biotechnology.