Prolyl isomerase Pin1: a promoter of cancer and a target for therapy

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[30]  Chen Liu,et al.  Imazamethabenz inhibits human breast cancer cell proliferation, migration and invasion via combination with Pin1. , 2017, Molecular medicine reports.

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[33]  Lin-Feng Chen,et al.  Prolyl isomerase PIN1 regulates the stability, transcriptional activity and oncogenic potential of BRD4 , 2017, Oncogene.

[34]  A. Bode,et al.  The Prolyl Isomerase Pin1 Is a Novel Target of 6,7,4′-Trihydroxyisoflavone for Suppressing Esophageal Cancer Growth , 2017, Cancer Prevention Research.

[35]  Xin-hua Liao,et al.  Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma , 2017, Oncotarget.

[36]  Dan Zhao,et al.  Manipulating PML SUMOylation via Silencing UBC9 and RNF4 Regulates Cardiac Fibrosis. , 2017, Molecular therapy : the journal of the American Society of Gene Therapy.

[37]  J. Shim,et al.  Rhein exhibits antitumorigenic effects by interfering with the interaction between prolyl isomerase Pin1 and c-Jun. , 2017, Oncology reports.

[38]  Y. Kwong,et al.  miR-874-3p is down-regulated in hepatocellular carcinoma and negatively regulates PIN1 expression , 2017, Oncotarget.

[39]  Ying-Jung Chen,et al.  Amsacrine-induced apoptosis of human leukemia U937 cells is mediated by the inhibition of AKT- and ERK-induced stabilization of MCL1 , 2017, Apoptosis.

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[43]  Xiaoguang Chen,et al.  Synthesis and Pin1 inhibitory activity of thiazole derivatives. , 2016, Bioorganic & medicinal chemistry.

[44]  M. Seiki,et al.  Mint3 potentiates TLR3/4- and RIG-I–induced IFN-β expression and antiviral immune responses , 2016, Proceedings of the National Academy of Sciences.

[45]  K. Jang,et al.  PIN1 in hepatocellular carcinoma is associated with TP53 gene status. , 2016, Oncology reports.

[46]  S. Park,et al.  Critical role of XBP1 in cancer signalling is regulated by PIN1. , 2016, The Biochemical journal.

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[51]  Xiao Zhen Zhou,et al.  The isomerase PIN1 controls numerous cancer-driving pathways and is a unique drug target , 2016, Nature Reviews Cancer.

[52]  G. Tsokos,et al.  Pin1‐Targeted Therapy for Systemic Lupus Erythematosus , 2016, Arthritis & rheumatology.

[53]  K. Aldape,et al.  Mitochondria-Translocated PGK1 Functions as a Protein Kinase to Coordinate Glycolysis and the TCA Cycle in Tumorigenesis. , 2016, Molecular cell.

[54]  Marco J. Morelli,et al.  Pin1 is required for sustained B cell proliferation upon oncogenic activation of Myc , 2016, Oncotarget.

[55]  M. V. Giuli,et al.  Prolyl-isomerase Pin1 controls Notch3 protein expression and regulates T-ALL progression , 2016, Oncogene.

[56]  Tao Wang,et al.  Pin1 modulates chemo-resistance by up-regulating FoxM1 and the involvements of Wnt/β-catenin signaling pathway in cervical cancer , 2016, Molecular and Cellular Biochemistry.

[57]  T. Hofmann,et al.  The DNA damage-induced cell death response: a roadmap to kill cancer cells , 2016, Cellular and Molecular Life Sciences.

[58]  K. Jung,et al.  Peptidyl Prolyl Isomerase PIN1 Directly Binds to and Stabilizes Hypoxia-Inducible Factor-1α , 2016, PloS one.

[59]  X. Cheng,et al.  Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs , 2015, Cell Death and Differentiation.

[60]  P. J. van der Spek,et al.  Targeted inhibition of metastatic melanoma through interference with Pin1-FOXM1 signaling , 2015, Oncogene.

[61]  R. Yazdanparast,et al.  Sensitizing effect of juglone is mediated by down regulation of Notch1 signaling pathway in trastuzumab-resistant SKBR3 cells , 2016, Apoptosis.

[62]  H. Zhang,et al.  Pin1 promotes prostate cancer cell proliferation and migration through activation of Wnt/β-catenin signaling , 2016, Clinical and Translational Oncology.

[63]  Shirui Tan,et al.  Nutrient deprivation-related OXPHOS/glycolysis interconversion via HIF-1α/C-MYC pathway in U251 cells , 2016, Tumor Biology.

[64]  Tao Wang,et al.  Pin1 modulates chemo-resistance by up-regulating FoxM1 and the involvements of Wnt/β-catenin signaling pathway in cervical cancer , 2016, Molecular and Cellular Biochemistry.

[65]  Patrik Lundström,et al.  Pre-Anchoring of Pin1 to Unphosphorylated c-Myc in a Fuzzy Complex Regulates c-Myc Activity. , 2015, Structure.

[66]  M. Miyazaki,et al.  Pin1 facilitates NF-κB activation and promotes tumour progression in human hepatocellular carcinoma , 2015, British Journal of Cancer.

[67]  Xiao Zhen Zhou,et al.  ATR Plays a Direct Antiapoptotic Role at Mitochondria, which Is Regulated by Prolyl Isomerase Pin1. , 2015, Molecular cell.

[68]  Xu Tao,et al.  The role of Pin1 protein in aging of human tendon stem/progenitor cells. , 2015, Biochemical and biophysical research communications.

[69]  D. Green,et al.  Pin1-Induced Proline Isomerization in Cytosolic p53 Mediates BAX Activation and Apoptosis. , 2015, Molecular cell.

[70]  Jianyi(Jay) Zhang,et al.  Bach1 Represses Wnt/β-Catenin Signaling and Angiogenesis. , 2015, Circulation research.

[71]  B. Novák,et al.  Human chromosome segregation involves multi-layered regulation of separase by the peptidyl-prolyl-isomerase Pin1. , 2015, Molecular cell.

[72]  Jisun An,et al.  Death Associated Protein Kinase (DAPK) -mediated neurodegenerative mechanisms in nematode excitotoxicity , 2015, BMC Neuroscience.

[73]  Christopher L. Warren,et al.  Peptidylprolyl Isomerase Pin1 Directly Enhances the DNA Binding Functions of Estrogen Receptor α* , 2015, The Journal of Biological Chemistry.

[74]  P. Pandolfi,et al.  Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer , 2015, Nature Medicine.

[75]  D. Butterfield,et al.  Pin1 cysteine-113 oxidation inhibits its catalytic activity and cellular function in Alzheimer's disease , 2015, Neurobiology of Disease.

[76]  F. Crea,et al.  Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes. , 2015, European heart journal.

[77]  P. Lu,et al.  Landscape of Pin1 in the cell cycle , 2015, Experimental biology and medicine.

[78]  I. Kwon,et al.  PIN1 Inhibition Suppresses Osteoclast Differentiation and Inflammatory Responses , 2015, Journal of dental research.

[79]  Y. Tong,et al.  Pin1 inhibits PP2A-mediated Rb dephosphorylation in regulation of cell cycle and S-phase DNA damage , 2015, Cell Death and Disease.

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[81]  Jeremy D. DeBarry,et al.  Theileria parasites secrete a prolyl isomerase to maintain host leukocyte transformation , 2014, Nature.

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[83]  M. Tang,et al.  SCP phosphatases suppress renal cell carcinoma by stabilizing PML and inhibiting mTOR/HIF signaling. , 2014, Cancer research.

[84]  D. Karunagaran,et al.  HPV16 E2 enhances the expression of NF-κB and STAT3 target genes and potentiates NF-κB activation by inflammatory mediators. , 2014, Cellular immunology.

[85]  M. Hsiao,et al.  MicroRNA-296-5p (miR-296-5p) functions as a tumor suppressor in prostate cancer by directly targeting Pin1. , 2014, Biochimica et biophysica acta.

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[89]  J. Lieberman,et al.  Prolyl isomerase Pin1 acts downstream of miR200c to promote cancer stem-like cell traits in breast cancer. , 2014, Cancer research.

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[93]  K. Nakayama,et al.  Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal , 2014, Proceedings of the National Academy of Sciences.

[94]  D. Rimm,et al.  Pin1 modulates ERα levels in breast cancer through inhibition of phosphorylation-dependent ubiquitination and degradation , 2014, Oncogene.

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[99]  T. Hirano,et al.  Inflammation amplifier, a new paradigm in cancer biology. , 2014, Cancer research.

[100]  Mark A Sussman,et al.  Differential Regulation of Cellular Senescence and Differentiation by Prolyl Isomerase Pin1 in Cardiac Progenitor Cells* , 2013, The Journal of Biological Chemistry.

[101]  Yu-Chyi Hwang,et al.  Destabilization of KLF10, a tumor suppressor, relies on thr93 phosphorylation and isomerase association. , 2013, Biochimica et biophysica acta.

[102]  Z. Xiao,et al.  Pin1 modulates p63α protein stability in regulation of cell survival, proliferation and tumor formation , 2013, Cell Death and Disease.

[103]  Chi-Ying F. Huang,et al.  Pin1 acts as a negative regulator of the G2/M transition by interacting with the Aurora-A–Bora complex , 2013, Journal of Cell Science.

[104]  G. Del Sal,et al.  Autophosphorylation and Pin1 binding coordinate DNA damage-induced HIPK2 activation and cell death , 2013, Proceedings of the National Academy of Sciences.

[105]  Zhihua Liu,et al.  Regulation of the MicroRNA 200b (miRNA-200b) by Transcriptional Regulators PEA3 and ELK-1 Protein Affects Expression of Pin1 Protein to Control Anoikis* , 2013, The Journal of Biological Chemistry.

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[107]  D. Litchfield,et al.  Mitotic Regulation of SEPT9 Protein by Cyclin-dependent Kinase 1 (Cdk1) and Pin1 Protein Is Important for the Completion of Cytokinesis* , 2013, The Journal of Biological Chemistry.

[108]  Sung-Chul Lim,et al.  Prolyl isomerase Pin1 negatively regulates the stability of SUV39H1 to promote tumorigenesis in breast cancer , 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

[109]  A. Loudon,et al.  Pin1 promotes GR transactivation by enhancing recruitment to target genes , 2013, Nucleic acids research.

[110]  H. Shih,et al.  SENP1 deSUMOylates and regulates Pin1 protein activity and cellular function. , 2013, Cancer research.

[111]  J. Malter,et al.  Pin1–FADD Interactions Regulate Fas-Mediated Apoptosis in Activated Eosinophils , 2013, The Journal of Immunology.

[112]  B. Gerrits,et al.  Prolyl isomerase PIN1 regulates DNA double-strand break repair by counteracting DNA end resection. , 2013, Molecular cell.

[113]  A. Sartori,et al.  Controlling DNA-end resection: a new task for CDKs , 2013, Front. Genet..

[114]  Y. Kwong,et al.  PIN1 inhibits apoptosis in hepatocellular carcinoma through modulation of the antiapoptotic function of survivin. , 2013, The American journal of pathology.

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[118]  M. Salto‐Tellez,et al.  Prolyl isomerase Pin1 down-regulates tumor suppressor RUNX3 in breast cancer , 2012, Oncogene.

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[121]  M. Gougerot-Pocidalo,et al.  The TLR7/8 Agonist CL097 Primes N-Formyl-Methionyl-Leucyl-Phenylalanine–Stimulated NADPH Oxidase Activation in Human Neutrophils: Critical Role of p47phox Phosphorylation and the Proline Isomerase Pin1 , 2012, The Journal of Immunology.

[122]  T. Uchida,et al.  Role of Pin1 Protein in the Pathogenesis of Nonalcoholic Steatohepatitis in a Rodent Model* , 2012, The Journal of Biological Chemistry.

[123]  M. R. Kim,et al.  Amurensin G inhibits angiogenesis and tumor growth of tamoxifen-resistant breast cancer via Pin1 inhibition. , 2012, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[124]  Erik van der Wal,et al.  Dual function of Pin1 in NR4A nuclear receptor activation: enhanced activity of NR4As and increased Nur77 protein stability. , 2012, Biochimica et biophysica acta.

[125]  K. Kang,et al.  Proyl isomerase Pin1 facilitates ubiquitin-mediated degradation of cyclin-dependent kinase 10 to induce tamoxifen resistance in breast cancer cells , 2012, Oncogene.

[126]  J. Decaprio,et al.  Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase. , 2012, Molecular cell.

[127]  Y. Liou,et al.  Prolyl isomerase Pin1 stabilizes and activates orphan nuclear receptor TR3 to promote mitogenesis , 2012, Oncogene.

[128]  R. Braun,et al.  Pin1 Protein Regulates Smad Protein Signaling and Pulmonary Fibrosis* , 2012, The Journal of Biological Chemistry.

[129]  Yong-Yeon Cho,et al.  TPA-induced cell transformation provokes a complex formation between Pin1 and 90 kDa ribosomal protein S6 kinase 2 , 2012, Molecular and Cellular Biochemistry.

[130]  B. Pulendran,et al.  Distinct TLR adjuvants differentially stimulate systemic and local innate immune responses in nonhuman primates. , 2012, Blood.

[131]  A. Klein-Szanto,et al.  Retinoblastoma tumor-suppressor protein phosphorylation and inactivation depend on direct interaction with Pin1 , 2012, Cell Death and Differentiation.

[132]  Gaoxi Xiao,et al.  RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α , 2012, Oncogene.

[133]  F. Khuri,et al.  Tyrosine phosphorylation of mitochondrial pyruvate dehydrogenase kinase 1 is important for cancer metabolism. , 2011, Molecular cell.

[134]  K. Aldape,et al.  Nuclear PKM2 regulates β-catenin transactivation upon EGFR activation , 2011, Nature.

[135]  S. Haslam,et al.  Regulation of Estrogen Receptor (cid:1) N-Terminus Conformation and Function by Peptidyl Prolyl Isomerase Pin1 , 2022 .

[136]  J. Lim,et al.  Mitogen-activated Protein Kinase Extracellular Signal-regulated Kinase 2 Phosphorylates and Promotes Pin1 Protein-dependent Promyelocytic Leukemia Protein Turnover* , 2011, The Journal of Biological Chemistry.

[137]  Hai Hu,et al.  The amplifier effect: how Pin1 empowers mutant p53 , 2011, Breast Cancer Research.

[138]  Weiwei Yang,et al.  Ras-Induced and Extracellular Signal-Regulated Kinase 1 and 2 Phosphorylation-Dependent Isomerization of Protein Tyrosine Phosphatase (PTP)-PEST by PIN1 Promotes FAK Dephosphorylation by PTP-PEST , 2011, Molecular and Cellular Biology.

[139]  Yu‐Min Lin,et al.  A Cullin3-KLHL20 Ubiquitin ligase-dependent pathway targets PML to potentiate HIF-1 signaling and prostate cancer progression. , 2011, Cancer Cell.

[140]  Antonio Rosato,et al.  A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. , 2011, Cancer cell.

[141]  A. Bode,et al.  Epigallocatechin-gallate Suppresses Tumorigenesis by Directly Targeting Pin1 , 2011, Cancer Prevention Research.

[142]  E. Israel,et al.  Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity , 2011, Nature Immunology.

[143]  J. Massagué,et al.  A Smad action turnover switch operated by WW domain readers of a phosphoserine code. , 2011, Genes & development.

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[145]  A. Goate,et al.  Death-associated protein kinase 1 phosphorylates Pin1 and inhibits its prolyl isomerase activity and cellular function. , 2011, Molecular cell.

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[147]  Weiping Yuan,et al.  Rictor/mTORC2 Is Essential for Maintaining a Balance Between β-Cell Proliferation and Cell Size , 2011, Diabetes.

[148]  Xiao Zhen Zhou,et al.  The prolyl isomerase Pin1 acts as a novel molecular switch for TNF-alpha-induced priming of the NADPH oxidase in human neutrophils. , 2010, Blood.

[149]  M. Saegusa,et al.  Pin1 acts as a modulator of cell proliferation through alteration in NF‐κB but not β‐catenin/TCF4 signalling in a subset of endometrial carcinoma cells , 2010, The Journal of pathology.

[150]  W. Heyer,et al.  Regulation of homologous recombination in eukaryotes. , 2010, Annual review of genetics.

[151]  M. R. Kim,et al.  Inhibition of angiogenesis by quercetin in tamoxifen-resistant breast cancer cells. , 2010, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

[152]  Weili Ma,et al.  BTG2 antagonizes Pin1 in response to mitogens and telomere disruption during replicative senescence , 2010, Aging cell.

[153]  Sung-Chul Lim,et al.  The Prolyl Isomerase Pin1 Induces LC-3 Expression and Mediates Tamoxifen Resistance in Breast Cancer* , 2010, The Journal of Biological Chemistry.

[154]  S. Bohlander,et al.  Elevated PIN1 expression by C/EBPα-p30 blocks C/EBPα-induced granulocytic differentiation through c-Jun in AML , 2010, Leukemia.

[155]  D. Pei,et al.  Membrane permeable cyclic peptidyl inhibitors against human Peptidylprolyl Isomerase Pin1. , 2010, Journal of medicinal chemistry.

[156]  B. Davis,et al.  Structure-guided design of alpha-amino acid-derived Pin1 inhibitors. , 2009, Bioorganic & medicinal chemistry letters.

[157]  J. Thomson,et al.  Structure-based design of novel human Pin1 inhibitors (II). , 2010, Bioorganic & medicinal chemistry letters.

[158]  J. Norman,et al.  Mutant p53 Drives Invasion by Promoting Integrin Recycling , 2009, Cell.

[159]  A. Ryo,et al.  Pin1 Promotes Transforming Growth Factor-β-induced Migration and Invasion* , 2009, The Journal of Biological Chemistry.

[160]  E. Han,et al.  Novel Role of Pin1 Induction in Type II Collagen-Mediated Rheumatoid Arthritis1 , 2009, The Journal of Immunology.

[161]  J. Bartek,et al.  The DNA-damage response in human biology and disease , 2009, Nature.

[162]  Samantha Greasley,et al.  Structure-based design of novel human Pin1 inhibitors (I). , 2009, Bioorganic & medicinal chemistry letters.

[163]  K. Khanna,et al.  The peptidyl-prolyl isomerase Pin1 regulates cytokinesis through Cep55. , 2009, Cancer research.

[164]  Dongquan Chen,et al.  The Prolyl Isomerase Pin1 Regulates the NF-κB Signaling Pathway and Interleukin-8 Expression in Glioblastoma , 2009, Oncogene.

[165]  M. R. Kim,et al.  Enhancement of vascular endothelial growth factor–mediated angiogenesis in tamoxifen-resistant breast cancer cells: role of Pin1 overexpression , 2009, Molecular Cancer Therapeutics.

[166]  K. Aldape,et al.  FAK phosphorylation by ERK primes ras-induced tyrosine dephosphorylation of FAK mediated by PIN1 and PTP-PEST. , 2009, Molecular cell.

[167]  I. Matsuura,et al.  Peptidyl-prolyl isomerase Pin1 markedly enhances the oncogenic activity of the rel proteins in the nuclear factor-kappaB family. , 2009, Cancer research.

[168]  L. Cantley,et al.  Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation , 2009, Science.

[169]  She Chen,et al.  TRIM21 Is Essential to Sustain IFN Regulatory Factor 3 Activation during Antiviral Response1 , 2009, The Journal of Immunology.

[170]  K. Miyazono,et al.  Pin1 Down-regulates Transforming Growth Factor-β (TGF-β) Signaling by Inducing Degradation of Smad Proteins* , 2009, Journal of Biological Chemistry.

[171]  I. Raška,et al.  Inhibition of the peptidyl-prolyl-isomerase Pin1 enhances the responses of acute myeloid leukemia cells to retinoic acid via stabilization of RARalpha and PML-RARalpha. , 2009, Cancer research.

[172]  Pier Paolo Di Fiore,et al.  The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer , 2009, Nature Cell Biology.

[173]  C. Borner,et al.  The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation , 2009, Nature Immunology.

[174]  K. Lu,et al.  Prolyl Isomerase Pin 1 is Highly Expressed in Her 2-Positive Breast Cancer and Regulates erbB 2 Protein Stability , 2009 .

[175]  Xiao Zhen Zhou,et al.  Essential role of Pin1 in the regulation of TRF1 stability and telomere maintenance , 2009, Nature Cell Biology.

[176]  K. Lu,et al.  Prolyl isomerase Pin1 is highly expressed in Her2-positive breast cancer and regulates erbB2 protein stability , 2008, Molecular Cancer.

[177]  Hung-Ying Kao,et al.  Cdk2 and Pin1 negatively regulate the transcriptional corepressor SMRT , 2008, The Journal of cell biology.

[178]  M. Hung,et al.  Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. , 2008, Cancer research.

[179]  J. Massagué,et al.  TGFβ in Cancer , 2008, Cell.

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