Apoptosis: Molecular Mechanisms

Apoptosis is an intrinsic cell-suicide programme which ensures proper development by maintaining tissue homeostasis and safeguarding the organism through the elimination of unwanted or virus-infected cells. Keywords: apoptosis; caspases; p53; Bcl-2; c-myc

[1]  H. Horvitz,et al.  Programmed cell death in Caenorhabditis elegans. , 1994, Current opinion in genetics & development.

[2]  N. Thornberry,et al.  Caspases: killer proteases. , 1997, Trends in biochemical sciences.

[3]  T. Mak,et al.  Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development , 1998, Cell.

[4]  D. Chao,et al.  BCL-2 family: regulators of cell death. , 1998, Annual review of immunology.

[5]  Keisuke Kuida,et al.  Reduced Apoptosis and Cytochrome c–Mediated Caspase Activation in Mice Lacking Caspase 9 , 1998, Cell.

[6]  A. Wyllie,et al.  Apoptosis: A Basic Biological Phenomenon with Wide-ranging Implications in Tissue Kinetics , 1972, British Journal of Cancer.

[7]  A. Wyllie,et al.  Apoptosis: an overview. , 1997, British medical bulletin.

[8]  A. Wyllie,et al.  Apoptosis (the 1992 Frank Rose Memorial Lecture). , 1993, British Journal of Cancer.

[9]  D. Fisher.  Apoptosis in cancer therapy: Crossing the threshold , 1994, Cell.

[10]  John C Reed,et al.  Bcl-2 family proteins , 1998, Oncogene.

[11]  A. Kimchi,et al.  Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6 , 1991, Nature.

[12]  K. Schulze-Osthoff,et al.  The role of caspases in development, immunity, and apoptotic signal transduction: lessons from knockout mice. , 1999, Immunity.

[13]  E. White,et al.  Life, death, and the pursuit of apoptosis. , 1996, Genes & development.

[14]  Gerard I. Evan,et al.  Induction of apoptosis in fibroblasts by c-myc protein , 1992, Cell.

[15]  G. Evan,et al.  A matter of life and cell death. , 1998, Science.

[16]  Xiaodong Wang,et al.  Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3 , 1997, Cell.

[17]  G. Salvesen,et al.  Caspases: Intracellular Signaling by Proteolysis , 1997, Cell.

[18]  S. Nagata,et al.  The Fas death factor , 1995, Science.

[19]  H. Horvitz,et al.  Genetics of programmed cell death in C. elegans: past, present and future. , 1998, Trends in genetics : TIG.

[20]  A. Wyllie,et al.  Cell death: the significance of apoptosis. , 1980, International review of cytology.