THE RESPONSE OF SINGLE AUDITORY-NERVE FIBERS TO ACOUSTIC STIMULATION

THE AIM OF the experiments described here was to study the response of single auditory-nerve fibers to acoustic stimulation delivered to the intact ear. Similar studies on other single afferent fibers have remarkably extended knowledge of the mode of action of diverse sensory mechanisms, while at the same time emphasizing their fundamental similarities. The present report describes the behavior of single auditory fibers and stresses similarities to other sensory nerves; in a subsequent paper we hope to relate these findings to a specific theory of action of the mammalian cochlea. METHOD Young cats anesthetized with dial (0.75 cc. per kilo) were used in these experiments. The postero-dorsal aspect of the auditory nerve was exposed by removing the lateral portion of the occipital bone where it meets the petrous bone. Bleeding from the sinus petrosus inferior was stopped by judicious cauterization or by Clotting Globulin. * A Ringer-filled glass micropipette with Ag-AgCl wire inserted as close as possible to the tip served as the active lead from the nerve. It was early established that pipettes with openings greater than 5~ do not allow isolation of the action potentials of single auditory fibers. The 3 to 5~ electrodes used have an impedance of about 1 megohm when tested on a resistance-capacity bridge between 0.6 and 2.5 kc. The microelectrode and the indifferent electrode (a silver plate in the neck muscles) led to a capacity-coupled amplifier (Grass) with an input done photographically

[1]  E. D. Adrian,et al.  The Basis of Sensation , 1928, The Indian Medical Gazette.

[2]  Leonard Thompson Troland.  The Psychophysiology of Auditory Qualities and Attributes , 1929 .

[3]  A. Forbes,et al.  QUANTITATIVE STUDIES OF THE NERVE IMPULSE , 1929 .

[4]  Alexander Forbes,et al.  Fatigue in peripheral nerve. , 1929 .

[5]  Harvey Fletcher.  A SPACE‐TIME PATTERN THEORY OF HEARING , 1930 .

[6]  C. Bray,et al.  Present possibilities for auditory theory. , 1930 .

[7]  E G Wever,et al.  ACTION CURRENTS IN THE AUDITORY NERVE IN RESPONSE TO ACOUSTICAL STIMULATION. , 1930, Proceedings of the National Academy of Sciences of the United States of America.

[8]  E. D. Adrian,et al.  The Mechanism of Nervous Action , 1932 .

[9]  H. Hoagland.  ELECTRICAL RESPONSES FROM THE LATERAL-LINE NERVES OF CATFISH. I , 1933, The Journal of general physiology.

[10]  B. Matthews.  Nerve endings in mammalian muscle , 1933, The Journal of physiology.

[11]  R. L. Nó.  The central projection of the nerve endings of the internal ear , 1933 .

[12]  A. J. Derbyshire,et al.  THE ACTION POTENTIALS OF THE AUDITORY NERVE , 1935 .

[13]  E. Adrian,et al.  Nervous discharges from the olfactory organs of fish , 1938, The Journal of physiology.

[14]  C. Pfaffmann.  Afferent impulses from the teeth resulting from a vibratory stimulus , 1939, The Journal of physiology.

[15]  A. Sand,et al.  The individual and integrated activity of the semicircular canals of the elasmobranch labyrinth , 1940, The Journal of physiology.

[16]  O Fitzgerald,et al.  Discharges from the sensory organs of the cat's vibrissae and the modification in their activity by ions , 1940, The Journal of physiology.

[17]  R. Granit.  THE RETINAL MECHANISM OF COLOR RECEPTION , 1941 .

[18]  C. Pfaffmann.  Gustatory afferent impulses , 1941 .

[19]  THE RETINAL MECHANISM OF COLOR RECEPTION , 1942 .