Anti‐allergic Effect of N‐Acetylneuraminic Acid in Guinea‐pigs

Abstract— The in‐vivo anti‐allergic effect of N‐acetylneuraminic acid (NANA) in guinea‐pigs passively sensitized with anti‐ovalbumin rabbit serum has been studied. NANA (20 mg kg−1 i.v.) inhibited bronchial anaphylaxis and the release of histamine into bronchoalveolar lavage fluid. NANA dose‐dependently inhibited heterologous passive cutaneous anaphylaxis and haemorrhaging in the passive Arthus reaction. However, it did not inhibit the release of histamine from sensitized minced lung tissue.

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