The Chinese Verbal Learning Test Specifically Assesses Hippocampal State

Background: Recently, the Chinese Verbal Learning Test (ChVLT) was developed to assess episodic memory in Chinese speakers. The goal of this analysis was to determine whether memory consolidation as measured by the ChVLT was specifically associated with hippocampal volume in patients with cognitive impairment. Methods: We administered the ChVLT to 22 Chinese-speaking patients with mild cognitive impairment and 9 patients with dementia and obtained hippocampal and cortical volumes from T1-weighted magnetic resonance imaging. Results: Linear regression revealed that hippocampal volume explained 9.9% of the variance in delayed memory (P = .018) after controlling for the effects of age, education, immediate recall after the last learning trial, overall level of cognitive impairment, and volumes of other cortical regions. conclusion: These results indicate that the ChVLT is specifically correlated with hippocampal volume, supporting its utility for detecting hippocampal disease and monitoring hippocampal state over time.

[1]  Hans-Jochen Heinze,et al.  Comparing manual and automatic segmentation of hippocampal volumes: Reliability and validity issues in younger and older brains , 2014, Human brain mapping.

[2]  C. Jack,et al.  Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance , 2012, Neurobiology of Aging.

[3]  Min Jae Baek,et al.  Comparison between the Story Recall Test and the Word-List Learning Test in Korean patients with mild cognitive impairment and early stage of Alzheimer's disease , 2012, Journal of clinical and experimental neuropsychology.

[4]  Satoshi Teramukai,et al.  Risk classification in mild cognitive impairment patients for developing Alzheimer's disease. , 2012, Journal of Alzheimer's disease : JAD.

[5]  Wei‐Ju Lee,et al.  Psychometrics of the Montreal Cognitive Assessment (MoCA) and its subscales: validation of the Taiwanese version of the MoCA and an item response theory analysis , 2011, International Psychogeriatrics.

[6]  Jesse S. Jin,et al.  Identification of Conversion from Mild Cognitive Impairment to Alzheimer's Disease Using Multivariate Predictors , 2011, PloS one.

[7]  H. Rosen,et al.  Recruitment of Chinese American elders into dementia research: the UCSF ADRC experience. , 2011, The Gerontologist.

[8]  Pei-Ning Wang,et al.  Learning and error patterns in the Chinese Verbal Learning Test in subjects with mild cognitive impairment and normal elderly. , 2011, Acta neurologica Taiwanica.

[9]  A. Dale,et al.  Relative capability of MR imaging and FDG PET to depict changes associated with prodromal and early Alzheimer disease. , 2010, Radiology.

[10]  S. Heckers,et al.  Brain autopsy findings in intensive care unit patients previously suffering from delirium: a pilot study. , 2010, Journal of critical care.

[11]  Michael Weiner,et al.  Automated 3d Mapping of Baseline and 12-month Associations between Three Verbal Memory Measures and Hippocampal Atrophy in 490 Adni Subjects and the Alzheimer's Disease Neuroimaging Initiative , 2022 .

[12]  Li Shen,et al.  Comparison of Manual and Automated Determination of Hippocampal Volumes in MCI and Early AD , 2010, Brain Imaging and Behavior.

[13]  Isabel Santana,et al.  Validation studies of the Portuguese experimental version of the Montreal Cognitive Assessment (MoCA): confirmatory factor analysis , 2010, Journal of Neurology.

[14]  Chi-Wei Huang,et al.  Validating the Chinese version of the Verbal Learning Test for screening Alzheimer’s disease , 2009, Journal of the International Neuropsychological Society.

[15]  Li Shen,et al.  Baseline MRI Predictors of Conversion from MCI to Probable AD in the ADNI Cohort , 2009, Current Alzheimer research.

[16]  P. Sachdev,et al.  In Vivo Hippocampal Measurement and Memory: A Comparison of Manual Tracing and Automated Segmentation in a Large Community-Based Sample , 2009, PloS one.

[17]  Martin Styner,et al.  A comparison of automated segmentation and manual tracing for quantifying hippocampal and amygdala volumes , 2009, NeuroImage.

[18]  Tomader Taha Abdel Rahman,et al.  Montreal Cognitive Assessment Arabic version: Reliability and validity prevalence of mild cognitive impairment among elderly attending geriatric clubs in Cairo , 2009, Geriatrics & gerontology international.

[19]  Bruce Fischl,et al.  Geometrically Accurate Topology-Correction of Cortical Surfaces Using Nonseparating Loops , 2007, IEEE Transactions on Medical Imaging.

[20]  A. M. Dale,et al.  A hybrid approach to the skull stripping problem in MRI , 2004, NeuroImage.

[21]  Norbert Schuff,et al.  Hippocampal volume and retention in Alzheimer's disease , 2004, Journal of the International Neuropsychological Society.

[22]  Nikos Makris,et al.  Automatically parcellating the human cerebral cortex. , 2004, Cerebral cortex.

[23]  Yi-Chung Lee,et al.  Cutoff Scores of the Cognitive Abilities Screening Instrument, Chinese Version in Screening of Dementia , 2002, Dementia and Geriatric Cognitive Disorders.

[24]  F. Craik.  Levels of processing: Past, present... and future? , 2002, Memory.

[25]  A. Dale,et al.  Whole Brain Segmentation Automated Labeling of Neuroanatomical Structures in the Human Brain , 2002, Neuron.

[26]  E. Tangalos,et al.  CME Practice parameter: , 2022 .

[27]  M Moscovitch,et al.  Anterograde and retrograde amnesia in rats with large hippocampal lesions , 2001, Hippocampus.

[28]  Anders M. Dale,et al.  Automated manifold surgery: constructing geometrically accurate and topologically correct models of the human cerebral cortex , 2001, IEEE Transactions on Medical Imaging.

[29]  R. Faber,et al.  Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria. , 1999, Neurology.

[30]  Anders M. Dale,et al.  Cortical Surface-Based Analysis I. Segmentation and Surface Reconstruction , 1999, NeuroImage.

[31]  M. Freedman,et al.  Frontotemporal lobar degeneration , 1998, Neurology.

[32]  Alan C. Evans,et al.  A nonparametric method for automatic correction of intensity nonuniformity in MRI data , 1998, IEEE Transactions on Medical Imaging.

[33]  Mark S. Seidenberg,et al.  Neuropsychological characteristics of the syndrome of mesial temporal lobe epilepsy. , 1997, Archives of neurology.

[34]  D. Spencer,et al.  Specificity in the correlation of verbal memory and hippocampal neuron loss: dissociation of memory, language, and verbal intellectual ability. , 1992, Journal of clinical and experimental neuropsychology.

[35]  M. Folstein,et al.  Clinical diagnosis of Alzheimer's disease , 1984, Neurology.

[36]  J. Pejme.  [Herpes simplex encephalitis]. , 1961, Svenska lakartidningen.

[37]  F. David,et al.  Statistical Estimates and Transformed Beta-Variables. , 1960 .