Molecular connectivity and hydrophobicity in the study of antifeedant activity of clerodane diterpenoids

Feeding deterrent activities of twelve clerodane diterpenoids towards Tenebrio molitor (Coleoptera: Tenebrionidae) larvae have been correlated using molecular connectivity indexes ( 3 χ c , 4 χ ν c , 0 ΔX) and hydrophobicity constants (log K'w) obtained by reverse-phase liquid chromatography (RPLC). The equations obtained suggest that both the degree of branching and the electronic characteristics of the compounds under study have a dominant role in the observed antifeedant activity. The information obtained from the correlations should be useful in designing more potent analogues

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