Gas holdup and liquid circulation rate in concentric-tube airlift bioreactors

A model gas holdup and liquid circulation rate is presented for airlift bioreactors based on a drift-flux model and an energy balance that takes into account the physical interactions between the liquid, the gas bubbles and the liquid-wake associated with the bubbles. A 250 1 pilot-scale concentric cylinder airlift bioreactor is used to obtain gas holdup and liquid circulation data for the fermentation of a Newtonian (Saccharomyces cerevisiae) and a non-Newtonian (Saccharopolyspora erythraea) culture. The data are interpreted in terms of the model equations and the agreement between the two is considered to be good.

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