Acetaminophen as a Renoprotective Adjunctive Treatment in Patients With Severe and Moderately Severe Falciparum Malaria: A Randomized, Controlled, Open-Label Trial

This randomized, controlled trial shows that acetaminophen reduces kidney dysfunction and risk of developing acute kidney injury, particularly in severe malaria patients who present with high plasma hemoglobin, supporting the hypothesis that acetaminophen inhibits cell-free hemoglobin-mediated renal tubular oxidative damage.

[1]  M. Aloni,et al.  [Acute renal failure and severe malaria in Congolese children living in Kinshasa, Democratic Republic of Congo]. , 2013, Nephrologie & therapeutique.

[2]  R. Temple,et al.  Hy's law: predicting serious hepatotoxicity , 2006, Pharmacoepidemiology and drug safety.

[3]  Nicholas J White,et al.  Standardizing the measurement of parasite clearance in falciparum malaria: the parasite clearance estimator , 2011, Malaria Journal.

[4]  M. Levy,et al.  The CRIT Study: Anemia and blood transfusion in the critically ill—Current clinical practice in the United States* , 2004, Critical care medicine.

[5]  B. Rumack,et al.  Acetaminophen poisoning and toxicity. , 1975, Pediatrics.

[6]  W. Buurman,et al.  Hemolysis is associated with acute kidney injury during major aortic surgery. , 2010, Kidney international.

[7]  J. Morrow,et al.  A series of prostaglandin F2-like compounds are produced in vivo in humans by a non-cyclooxygenase, free radical-catalyzed mechanism. , 1990, Proceedings of the National Academy of Sciences of the United States of America.

[8]  S. Pukrittayakamee,et al.  Fever in uncomplicated Plasmodium falciparum malaria: randomized double-'blind' comparison of ibuprofen and paracetamol treatment. , 1995, Transactions of the Royal Society of Tropical Medicine and Hygiene.

[9]  P. Kofoed,et al.  Paracetamol versus placebo in treatment of non-severe malaria in children in Guinea-Bissau: a randomized controlled trial , 2011, Malaria Journal.

[10]  Timothy William,et al.  Severe Plasmodium knowlesi Malaria in a Tertiary Care Hospital, Sabah, Malaysia , 2011, Emerging infectious diseases.

[11]  J. Fessel,et al.  Discovery of lipid peroxidation products formed in vivo with a substituted tetrahydrofuran ring (isofurans) that are favored by increased oxygen tension , 2002, Proceedings of the National Academy of Sciences of the United States of America.

[12]  R. Price,et al.  Relationship of cell-free hemoglobin to impaired endothelial nitric oxide bioavailability and perfusion in severe falciparum malaria. , 2009, Journal of Infectious Diseases.

[13]  T. Yeo,et al.  Intravascular haemolysis with haemoglobinuria in a splenectomized patient with severe Plasmodium knowlesi malaria , 2016, Malaria Journal.

[14]  P. Kremsner,et al.  Effect of paracetamol on parasite clearance time in Plasmodium falciparum malaria , 1997, The Lancet.

[15]  A. Dinda,et al.  Spectrum of renal involvement in paroxysmal nocturnal hemoglobinuria: report of three cases and a brief review of the literature , 2008, International Urology and Nephrology.

[16]  T. Yeo,et al.  Cell-free hemoglobin mediated oxidative stress is associated with acute kidney injury and renal replacement therapy in severe falciparum malaria: an observational study , 2017, BMC Infectious Diseases.

[17]  T. Yeo,et al.  Dimethylarginines: endogenous inhibitors of nitric oxide synthesis in children with falciparum malaria. , 2014, The Journal of infectious diseases.

[18]  D. Back,et al.  Paracetamol disposition in Thai patients during and after treatment of falciparum malaria , 2004, European Journal of Clinical Pharmacology.

[19]  Sheldon Chen.  Retooling the creatinine clearance equation to estimate kinetic GFR when the plasma creatinine is changing acutely. , 2013, Journal of the American Society of Nephrology : JASN.

[20]  Norbert Lameire,et al.  Notice , 2012, Kidney International Supplements.

[21]  Arjen Dondorp,et al.  Artesunate versus quinine for treatment of severe falciparum malaria: a randomised trial , 2005, The Lancet.

[22]  I. Hambleton,et al.  Intravenous infusion of haptoglobin for the prevention of adverse clinical outcome in Sickle Cell Disease. , 2015, Medical hypotheses.

[23]  K. Bojang,et al.  Predicting the Clinical Outcome of Severe Falciparum Malaria in African Children: Findings From a Large Randomized Trial , 2012, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[24]  Clare K. Carney,et al.  Acetaminophen inhibits hemoprotein-catalyzed lipid peroxidation and attenuates rhabdomyolysis-induced renal failure , 2010, Proceedings of the National Academy of Sciences.

[25]  G. Bernard,et al.  Randomized, Placebo-Controlled Trial of Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis: The Acetaminophen for the Reduction of Oxidative Injury in Severe Sepsis Trial* , 2015, Critical care medicine.

[26]  M. Aloni,et al.  Insuffisance rénale aiguë dans les formes graves du paludisme chez les enfants vivant à Kinshasa , 2012 .

[27]  N. White,et al.  Acute renal failure in patients with severe falciparum malaria. , 1992, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

[28]  B. Rumack,et al.  Pharmacokinetics of acetaminophen in children. , 1978, Pediatrics.

[29]  A Rogier T Donders,et al.  Dealing with missing outcome data in randomized trials and observational studies. , 2012, American journal of epidemiology.

[30]  K. Kain,et al.  Acute Kidney Injury Is Common in Pediatric Severe Malaria and Is Associated With Increased Mortality , 2016, Open forum infectious diseases.