Nd:YAG laser‐Induced interstitial hyperthermia using a long frosted contact probe

The heating potential of a closed loop interstitial hyperthermia system employing 1,064 nm laser light in conjunction with a long frosted contact probe was investigated in hind limb muscle of anesthetized dogs. The laser system was an Nd:YAG surgical laser modified with a single channel thermometry unit, a computer, a printer, and a computer‐controlled laser exposure shutter. The long frosted laser probe was implanted into the muscle, and 3.12–5.00 Watts of laser power was delivered interstitially. Temperature distribution was measured in three dimensions around the frosted probe. The temperature distributions generated by this technique were satisfactory for producin desired hyperthermia temperatures in an approximately 3.5 cm3 cylindrical tissue volume. A multiple laser delivery system is needed to induce interstitial hyperthermia in large tumors.

[1]  R. Anderson,et al.  TRANSMITTANCE OF NONIONIZING RADIATION IN HUMAN TISSUES * , 1981, Photochemistry and photobiology.

[2]  T. Dougherty,et al.  Potentiation of photodynamic therapy by heat: Effect of sequence and time interval between treatments in vivo , 1985, Lasers in surgery and medicine.

[3]  S. K. Powers,et al.  Hyperthermia from interstitial laser irradiation in normal rat brain , 1987, Lasers in surgery and medicine.

[4]  M Ohyama,et al.  Laserthermia: A new computer‐controlled contact Nd:YAG system for interstitial local hyperthermia , 1988, Lasers in surgery and medicine.

[5]  A J Welch,et al.  Measured and predicted laser-induced temperature rises in the rabbit fundus. , 1974, Investigative ophthalmology.

[6]  B W Henderson,et al.  Hyperthermic potentiation of photodynamic therapy employing photofrin I and II: Comparison of results using three animal tumor models , 1987, Lasers in surgery and medicine.

[7]  P R Morrison,et al.  Nd:YAG laser‐induced hyperthermia in a mouse tumor model , 1988, Lasers in surgery and medicine.

[8]  J. Hand,et al.  Heating techniques in hyperthermia , 1981 .

[9]  Garrett D. Polhamus,et al.  Measurement and Prediction of Thermal Injury in the Retina of the Rhesus Monkey , 1984, IEEE Transactions on Biomedical Engineering.

[10]  L. O. Svaasand,et al.  Thermal and optical properties of living tissue: Application to laser‐induced hyperthermia , 1985, Lasers in surgery and medicine.

[11]  C. Durney,et al.  Hyperthermia production for cancer therapy: a review of fundamentals and methods. , 1981, The Journal of microwave power.