Network Medicine in Disease Analysis and Therapeutics

Two parallel trends are occurring in drug discovery. The first is that we are moving away from a symptom‐based disease classification system to a system based on molecules and molecular states. The second is that we are shifting from targeting a single molecule toward targeting multiple molecules, pathways, or networks. Network medicine is an approach to understanding disease and discovering therapeutics looking at many molecules and how they interrelate, and it may play a critical role in the adoption of both trends.

[1]  P. Sorger,et al.  Sequential Application of Anticancer Drugs Enhances Cell Death by Rewiring Apoptotic Signaling Networks , 2012, Cell.

[2]  Douglas G Altman,et al.  Key Issues in Conducting a Meta-Analysis of Gene Expression Microarray Datasets , 2008, PLoS medicine.

[3]  A. Barabasi,et al.  Network medicine : a network-based approach to human disease , 2010 .

[4]  A. Hopkins.  Network pharmacology: the next paradigm in drug discovery. , 2008, Nature chemical biology.

[5]  Katarzyna H. Kaminska,et al.  Characterization of drug-induced transcriptional modules: towards drug repositioning and functional understanding , 2013, Molecular systems biology.

[6]  Alexander A. Morgan,et al.  Discovery and Preclinical Validation of Drug Indications Using Compendia of Public Gene Expression Data , 2011, Science Translational Medicine.

[7]  Steven J. M. Jones,et al.  Comprehensive molecular portraits of human breast tumors , 2012, Nature.

[8]  A. Barabasi,et al.  The human disease network , 2007, Proceedings of the National Academy of Sciences.

[9]  Steven J. M. Jones,et al.  Comprehensive molecular portraits of human breast tumours , 2013 .

[10]  Katherine R. Singleton,et al.  A mechanism of resistance to gefitinib mediated by cellular reprogramming and the acquisition of an FGF2-FGFR1 autocrine growth loop , 2013, Oncogenesis.

[11]  Joel Dudley,et al.  Network-Based Elucidation of Human Disease Similarities Reveals Common Functional Modules Enriched for Pluripotent Drug Targets , 2010, PLoS Comput. Biol..

[12]  Aleix Prat Aparicio.  Comprehensive molecular portraits of human breast tumours , 2012 .