Long-Term Survival and Late Deaths after Allogeneic Bone Marrow Transplantation

Background and Methods It is uncertain whether mortality rates among patients who have undergone bone marrow transplantation return to the level of the mortality rates of the general population. We analyzed the characteristics of 6691 patients listed in the International Bone Marrow Transplant Registry. All the patients were free of their original disease two years after allogeneic bone marrow transplantation. Mortality rates in this cohort were compared with those of an age-, sex-, and nationality-matched general population. Cox proportional-hazards regression was used to identify risk factors for death more than two years after transplantation (late death). Results Among patients who were free of disease two years after transplantation, the probability of living for five more years was 89 percent (95 percent confidence interval, 88 to 90 percent). Among patients who underwent transplantation for aplastic anemia, the risk of death by the sixth year after transplantation did not differ significantly from ...

[1]  直子 加藤,et al.  Graft-Versus-host Disease , 1999 .

[2]  H. Deeg,et al.  Long-term outcome after marrow transplantation for severe aplastic anemia. , 1998, Blood.

[3]  E. Estey,et al.  Implications of potential cure in acute myelogenous leukemia: development of subsequent cancer and return to work. , 1997, Blood.

[4]  E. Freireich,et al.  Conclusions regarding leukemia long‐term survival , 1997, Cancer.

[5]  F. Appelbaum,et al.  Long‐term survival after chemotherapy for acute myeloid leukemia , 1997, Cancer.

[6]  M. Horowitz,et al.  An update from the International Bone Marrow Transplant Registry and the Autologous Blood and Marrow Transplant Registry on current activity in hematopoietic stem cell transplantation , 1997, Current opinion in hematology.

[7]  Beatty Pg.  Clinical and managed care issues in blood and marrow transplantation for hematologic diseases. Report of a symposium, 14 March 1996, Washington, DC. , 1997 .

[8]  C. Chastang,et al.  Outcome of cord-blood transplantation from related and unrelated donors , 1997 .

[9]  J. Goldman.  Optimizing treatment for chronic myeloid leukemia. , 1997, The New England journal of medicine.

[10]  J. Klein,et al.  Bone marrow transplantation for severe aplastic anemia: has outcome improved? , 1997, Blood.

[11]  C. Pui,et al.  Late mortality of long-term survivors of childhood cancer. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[12]  P. Henslee-Downey,et al.  Use of partially mismatched related donors extends access to allogeneic marrow transplant. , 1997, Blood.

[13]  J. Klein,et al.  Survival Analysis: Techniques for Censored and Truncated Data , 1997 .

[14]  R. Hoover,et al.  Solid cancers after bone marrow transplantation. , 1997, The New England journal of medicine.

[15]  K. Sullivan,et al.  Infectious morbidity in long‐term survivors of allogeneic marrow transplantation is associated with low CD4 T cell counts , 1997, American journal of hematology.

[16]  A. Tichelli,et al.  Health and Functional Status of Long-Term Survivors of Bone Marrow Transplantation , 1997, Annals of Internal Medicine.

[17]  Robert H. Collins,et al.  Donor leukocyte infusions in 140 patients with relapsed malignancy after allogeneic bone marrow transplantation. , 1997, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

[18]  D. Cella,et al.  Measuring quality of life: 1995 update. , 1995, Oncology.

[19]  A Ferrant,et al.  Graft-versus-leukemia effect of donor lymphocyte transfusions in marrow grafted patients. , 1995, Blood.

[20]  N. Young,et al.  The treatment of severe acquired aplastic anemia. , 1995, Blood.

[21]  F. Mandelli,et al.  Autologous or allogeneic bone marrow transplantation compared with intensive chemotherapy in acute myelogenous leukemia. European Organization for Research and Treatment of Cancer (EORTC) and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto (GIMEMA) Leukemia Cooperative Groups. , 1995, The New England journal of medicine.

[22]  J. Shuster,et al.  Bone marrow transplants from HLA-identical siblings as compared with chemotherapy for children with acute lymphoblastic leukemia in a second remission. , 1994, The New England journal of medicine.

[23]  M. Hawkins,et al.  Late deaths and survival after childhood cancer: implications for cure , 1994, BMJ.

[24]  T. Fears,et al.  Death during adulthood in survivors of childhood and adolescent cancer , 1994, Cancer.

[25]  D. Green,et al.  Factors that influence the further survival of patients who survive for five years after the diagnosis of cancer in childhood or adolescence. , 1994, Medical and pediatric oncology.

[26]  J. Hansen,et al.  Analysis of 462 transplantations from unrelated donors facilitated by the National Marrow Donor Program. , 1993, The New England journal of medicine.

[27]  M. Hawkins,et al.  Late deaths after treatment for childhood cancer. , 1990, Archives of disease in childhood.

[28]  M Vaeth,et al.  Simple parametric and nonparametric models for excess and relative mortality. , 1989, Biometrics.