[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor.

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

[1]  Luke G Green,et al.  A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes. , 2002, Angewandte Chemie.

[2]  J. Herscovici,et al.  Reusable polymer-supported catalyst for the [3+2] Huisgen cycloaddition in automation protocols. , 2006, Organic letters.

[3]  Morten Meldal,et al.  Peptidotriazoles on solid phase: [1,2,3]-triazoles by regiospecific copper(i)-catalyzed 1,3-dipolar cycloadditions of terminal alkynes to azides. , 2002, The Journal of organic chemistry.

[4]  M. Finn,et al.  Mechanism of the ligand-free CuI-catalyzed azide-alkyne cycloaddition reaction. , 2005, Angewandte Chemie.

[5]  Steven V Ley,et al.  Fully automated continuous flow synthesis of 4,5-disubstituted oxazoles. , 2006, Organic letters.

[6]  Hans G. Börner,et al.  Combining Atom Transfer Radical Polymerization and Click Chemistry: A Versatile Method for the Preparation of End‐Functional Polymers , 2005 .

[7]  S. Hotha,et al.  "Click chemistry" inspired synthesis of pseudo-oligosaccharides and amino acid glycoconjugates. , 2006, The Journal of organic chemistry.

[8]  M. G. Finn,et al.  Click Chemistry: Diverse Chemical Function from a Few Good Reactions. , 2001, Angewandte Chemie.

[9]  Philip Hodge,et al.  Synthesis of Organic Compounds Using Polymer-Supported Reagents, Catalysts, and/or Scavengers in Benchtop Flow Systems† , 2005 .

[10]  Zoran Radić,et al.  In situ selection of lead compounds by click chemistry: target-guided optimization of acetylcholinesterase inhibitors. , 2005, Journal of the American Chemical Society.

[11]  Wolfgang H. Binder and Christian Kluger Azide/Alkyne-“Click” Reactions: Applications in Material Science and Organic Synthesis , 2006 .

[12]  B. Lipshutz,et al.  Heterogeneous copper-in-charcoal-catalyzed click chemistry. , 2006, Angewandte Chemie.

[13]  H. Kolb,et al.  The growing impact of click chemistry on drug discovery. , 2003, Drug discovery today.