p50α/p55α Phosphoinositide 3-Kinase Knockout Mice Exhibit Enhanced Insulin Sensitivity
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C. Kahn | K. Ueki | L. Goodyear | Dong Chen | F. Mauvais-Jarvis | M. Bluher | S. Fisher | A. Jozsi | C. R. Kahn | Simon J. Fisher | Laurie J. Goodyear
[1] A. Hamburger,et al. The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest , 2003, Molecular and Cellular Biology.
[2] Kohjiro Ueki,et al. Molecular Balance between the Regulatory and Catalytic Subunits of Phosphoinositide 3-Kinase Regulates Cell Signaling and Survival , 2002, Molecular and Cellular Biology.
[3] Kohjiro Ueki,et al. Increased insulin sensitivity in mice lacking p85β subunit of phosphoinositide 3-kinase , 2001, Proceedings of the National Academy of Sciences of the United States of America.
[4] C. Kahn,et al. Positive and Negative Regulation of Phosphoinositide 3-Kinase-Dependent Signaling Pathways by Three Different Gene Products of the p85α Regulatory Subunit , 2000, Molecular and Cellular Biology.
[5] Daniel A. Pollard,et al. Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α , 2000, Nature Genetics.
[6] T. Asano,et al. The N-terminal 34 residues of the 55 kDa regulatory subunits of phosphoinositide 3-kinase interact with tubulin. , 2000, The Biochemical journal.
[7] Y. Matsuzawa,et al. Increased insulin sensitivity and hypoglycaemia in mice lacking the p85α subunit of phosphoinositide 3–kinase , 1999, Nature Genetics.
[8] C. Kahn,et al. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. , 1998, Molecular cell.
[9] K. Siddle,et al. Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. , 1998, The Biochemical journal.
[10] J. Backer,et al. Regulation of the p85/p110 Phosphatidylinositol 3′-Kinase: Stabilization and Inhibition of the p110α Catalytic Subunit by the p85 Regulatory Subunit , 1998, Molecular and Cellular Biology.
[11] B. Kahn,et al. Amelioration of insulin resistance in streptozotocin diabetic mice by transgenic overexpression of GLUT4 driven by an adipose-specific promoter. , 1997, Endocrinology.
[12] Y. Yazaki,et al. p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin* , 1997, The Journal of Biological Chemistry.
[13] L. Cantley,et al. Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene , 1996 .
[14] C. Mobbs,et al. Injection with gold thioglucose impairs sensitivity to glucose: evidence that glucose-responsive neurons are important for long-term regulation of body weight , 1996, Brain Research.
[15] C. Kahn,et al. Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain , 1996, Molecular and cellular biology.
[16] Y. Yazaki,et al. A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85 Gene (*) , 1996, The Journal of Biological Chemistry.
[17] M. White,et al. The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase , 1995, Molecular and cellular biology.
[18] B. Kahn,et al. Transgenic GLUT-4 overexpression in fat enhances glucose metabolism: preferential effect on fatty acid synthesis. , 1995, The American journal of physiology.
[19] E. Van Obberghen,et al. Early alteration of insulin stimulation of PI 3-kinase in muscle and adipocyte from gold thioglucose obese mice. , 1995, The American journal of physiology.
[20] T. Kitamura,et al. 1-Phosphatidylinositol 3-kinase activity is required for insulin-stimulated glucose transport but not for RAS activation in CHO cells. , 1994, Proceedings of the National Academy of Sciences of the United States of America.
[21] J. Blenis,et al. Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation , 1994, Molecular and cellular biology.
[22] T. Okada,et al. Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. , 1994, The Journal of biological chemistry.
[23] G. Panayotou,et al. Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase , 1991, Cell.
[24] S. Cushman,et al. Determinations of adipose cell size and number in suspensions of isolated rat and human adipose cells. , 1978, Journal of lipid research.
[25] Y. Yazaki,et al. p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin. , 1997, The Journal of biological chemistry.
[26] L. Cantley,et al. Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. , 1996, Genomics.