Thalamic Projection Fiber Integrity in de novo Parkinson Disease

BACKGROUND AND PURPOSE: Postmortem studies of advanced PD have revealed disease-related pathology in the thalamus with an apparent predilection for specific thalamic nuclei. In the present study, we used DTI to investigate in vivo the microstructural integrity of 6 thalamic regions in de novo patients with PD relative to healthy controls. MATERIALS AND METHODS: Forty subjects (20 with early stage untreated PD and 20 age- and sex-matched controls) were studied with a high-resolution DTI protocol at 3T to investigate the integrity of thalamic nuclei projection fibers. Two blinded, independent raters drew ROIs in the following 6 thalamic regions: AN, VA, VL, DM, VPL/VPM, and PU. FA values were then calculated from the projection fibers in each region. RESULTS: FA values were reduced significantly in the fibers projecting from the AN, VA, and DM, but not the VPL/VPM and PU, in the PD group compared with the control group. In addition, there was a reduction in FA values that approached significance in the VL of patients with PD. These findings were consistent across both raters. CONCLUSIONS: The present study provides preliminary in vivo evidence of thalamic projection fiber degeneration in de novo PD and sheds light on the extent of disrupted thalamic circuitry as a result of the disease itself.

[1]  Wang Zhan,et al.  Regional alterations of brain microstructure in Parkinson's disease using diffusion tensor imaging , 2012, Movement disorders : official journal of the Movement Disorder Society.

[2]  Martin Styner,et al.  Combined R2* and Diffusion Tensor Imaging Changes in the Substantia Nigra in Parkinson's Disease , 2011, Movement disorders : official journal of the Movement Disorder Society.

[3]  J. Frank,et al.  The contribution of gliosis to diffusion tensor anisotropy and tractography following traumatic brain injury: validation in the rat using Fourier analysis of stained tissue sections. , 2011, Brain : a journal of neurology.

[4]  Sang Ho Ahn,et al.  Dentatorubrothalamic tract in human brain: diffusion tensor tractography study , 2011, Neuroradiology.

[5]  D. Vaillancourt,et al.  Use of MRI to monitor Parkinson’s disease , 2011 .

[6]  D. Vaillancourt,et al.  Basal ganglia hypoactivity during grip force in drug naïve Parkinson's disease , 2010, Human brain mapping.

[7]  A. Stefani,et al.  Magnetic resonance imaging markers of Parkinson's disease nigrostriatal signature. , 2010, Brain : a journal of neurology.

[8]  F. Skidmore,et al.  White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study , 2010, American Journal of Neuroradiology.

[9]  O. Speck,et al.  High Field fMRI Reveals Thalamocortical Integration of Segregated Cognitive and Emotional Processing in Mediodorsal and Intralaminar Thalamic Nuclei , 2010, Front. Neuroanat..

[10]  D. Vaillancourt,et al.  Blood oxygenation level–dependent activation in basal ganglia nuclei relates to specific symptoms in de novo Parkinson's disease , 2010, Movement disorders : official journal of the Movement Disorder Society.

[11]  M. Schocke,et al.  Significance of MRI in Diagnosis and Differential Diagnosis of Parkinson’s Disease , 2010, Neurodegenerative Diseases.

[12]  Timothy Edward John Behrens,et al.  Topography of connections between human prefrontal cortex and mediodorsal thalamus studied with diffusion tractography , 2010, NeuroImage.

[13]  M. Fox,et al.  Noninvasive functional and structural connectivity mapping of the human thalamocortical system. , 2010, Cerebral cortex.

[14]  B. Barbiroli,et al.  Diffusion tensor MRI changes in cerebellar structures of patients with familial essential tremor , 2010, Neurology.

[15]  P. Gorelick,et al.  Thalamic integrity underlies executive dysfunction in traumatic brain injury , 2010, Neurology.

[16]  F. Nobili,et al.  Cognitive‐nigrostriatal relationships in de novo, drug‐naïve Parkinson's disease patients: A [I‐123]FP‐CIT SPECT study , 2010, Movement disorders : official journal of the Movement Disorder Society.

[17]  G. Halliday.  Thalamic changes in Parkinson's disease. , 2009, Parkinsonism & related disorders.

[18]  A. Albanese,et al.  White Matter Involvement in Idiopathic Parkinson Disease: A Diffusion Tensor Imaging Study , 2009, American Journal of Neuroradiology.

[19]  M. B. Spraker,et al.  High-resolution diffusion tensor imaging in the substantia nigra of de novo Parkinson disease , 2009, Neurology.

[20]  G. Halliday,et al.  Intralaminar nuclei of the thalamus in Lewy body diseases , 2009, Brain Research Bulletin.

[21]  Rafeef Abugharbieh,et al.  Shape (but not volume) changes in the thalami in Parkinson disease , 2008, BMC neurology.

[22]  A. Bizzi,et al.  Elevating tensor rank increases anisotropy in brain areas associated with intra‐voxel orientational heterogeneity (IVOH): a generalised DTI (GDTI) study , 2008, NMR in biomedicine.

[23]  M. Mallar Chakravarty,et al.  The Connectivity of the Human Pulvinar: A Diffusion Tensor Imaging Tractography Study , 2007, Int. J. Biomed. Imaging.

[24]  Susumu Mori,et al.  High resolution diffusion tensor imaging of axonal damage in focal inflammatory and demyelinating lesions in rat spinal cord. , 2007, Brain : a journal of neurology.

[25]  S Fook-Chong,et al.  Case control study of diffusion tensor imaging in Parkinson’s disease , 2007, Journal of Neurology, Neurosurgery, and Psychiatry.

[26]  Khader M. Hasan,et al.  Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease , 2007, Neurobiology of Disease.

[27]  A. Morel.  THE THALAMUS AND BEHAVIOR: EFFECTS OF ANATOMICALLY DISTINCT STROKES , 2007, Neurology.

[28]  K. Chaudhuri,et al.  Non-motor symptoms of Parkinson's disease: diagnosis and management , 2006, The Lancet Neurology.

[29]  Hangyi Jiang,et al.  DtiStudio: Resource program for diffusion tensor computation and fiber bundle tracking , 2006, Comput. Methods Programs Biomed..

[30]  Y Nakata,et al.  Early pathological changes in the parkinsonian brain demonstrated by diffusion tensor MRI , 2004, Journal of Neurology, Neurosurgery & Psychiatry.

[31]  P. Morrish.  How valid is dopamine transporter imaging as a surrogate marker in research trials in Parkinson's disease? , 2003, Movement disorders : official journal of the Movement Disorder Society.

[32]  J. Schmahmann.  Vascular syndromes of the thalamus. , 2003, Stroke.

[33]  Murat Emre,et al.  What causes mental dysfunction in Parkinson's disease? , 2003, Movement disorders : official journal of the Movement Disorder Society.

[34]  Timothy Edward John Behrens,et al.  Non-invasive mapping of connections between human thalamus and cortex using diffusion imaging , 2003, Nature Neuroscience.

[35]  H. Braak,et al.  Staging of brain pathology related to sporadic Parkinson’s disease , 2003, Neurobiology of Aging.

[36]  M. Witter,et al.  The intralaminar and midline nuclei of the thalamus. Anatomical and functional evidence for participation in processes of arousal and awareness , 2002, Brain Research Reviews.

[37]  H. Braak,et al.  Parkinson’s disease: the thalamic components of the limbic loop are severely impaired by α-synuclein immunopositive inclusion body pathology , 2002, Neurobiology of Aging.

[38]  A J Lees,et al.  What features improve the accuracy of clinical diagnosis in Parkinson's disease: A clinicopathologic study , 2001, Neurology.

[39]  G. Halliday,et al.  Loss of thalamic intralaminar nuclei in progressive supranuclear palsy and Parkinson's disease: clinical and therapeutic implications. , 2000, Brain : a journal of neurology.

[40]  R. Passingham,et al.  Self-initiated versus externally triggered movements. II. The effect of movement predictability on regional cerebral blood flow. , 2000, Brain : a journal of neurology.

[41]  H. Braak,et al.  Pathoanatomy of Parkinson’s disease , 2000, Journal of Neurology.

[42]  G. Halliday,et al.  Degeneration of the centré median–parafascicular complex in Parkinson's disease , 2000, Annals of neurology.

[43]  J. Gabrieli,et al.  Myelination and organization of the frontal white matter in children: a diffusion tensor MRI study. , 1999, Neuroreport.

[44]  Alan C. Evans,et al.  Abnormal basal ganglia outflow in Parkinson's disease identified with PET. Implications for higher cortical functions. , 1998, Brain : a journal of neurology.

[45]  R W Cox,et al.  AFNI: software for analysis and visualization of functional magnetic resonance neuroimages. , 1996, Computers and biomedical research, an international journal.

[46]  J. Kucharczyk,et al.  Identification of “Premyelination” by Diffusion‐Weighted MRI , 1995, Journal of computer assisted tomography.

[47]  J. Hughes,et al.  Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinico-pathological study of 100 cases. , 1992, Journal of neurology, neurosurgery, and psychiatry.

[48]  Tony Ro,et al.  The role of the human pulvinar in visual attention and action: evidence from temporal-order judgment, saccade decision, and antisaccade tasks. , 2008, Progress in brain research.

[49]  H. Blumenfeld,et al.  Neuroanatomy through Clinical Cases , 2002 .

[50]  J. Pearce.  Howard Henry Tooth (1856–1925) , 2000, Journal of Neurology.

[51]  R. Passingham,et al.  Self-initiated versus externally triggered movements. I. An investigation using measurement of regional cerebral blood flow with PET and movement-related potentials in normal and Parkinson's disease subjects. , 1996, Brain : a journal of neurology.

[52]  P. Basser,et al.  MR diffusion tensor spectroscopy and imaging. , 1994, Biophysical journal.