Stoffwechselprodukte von Mikroorganismen 143. Mitteilung. Echinocandin B, ein neuartiges Polypeptid‐Antibioticum aus Aspergillus nidulans var. echinulatus: Isolierung und Bausteine

From a strain of Aspergillus nidulans var. echinulatus, A 32204, echinocandin, a novel polypeptide antibiotic complex with high and specific anti-yeast activity was isolated. The main component, echinocandin B, was separated by counter-current distribution. A tentative molecular formula C52H81N7O18 is discussed. The antibiotic is characterized by its IR. and NMR. spectra and by its characteristic hydrolytic degradation products: linoilic acid, L-4-hydroxyproline, L-4-oxoproline, (2S, 3S, 4S)-4-methyl-3-hydroxy-proline, L-threonine (2 mols), and 1-(p-hydroxyphenyl)-3-amino-propan-2-one.

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