论文信息 - Imaging cellular microtubules with the atomic-force microscope

Imaging cellular microtubules with the atomic-force microscope

We have immobilized chemically-fixed cellular microtubules and microtubule protein polymers on glow-discharged glass discs for scanning by atomic force microscopy (AFM). The images obtained by AFM resembled those obtained by conventional transmission electron microscopy of the same material. The AFM images can resolve some of the surface features of microtubules to 10 nm. Improvements in the techniques promise resolution approaching molecular dimensions.

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