Gene Expression Regulation underlying Osteo-, Adipo-, and Chondro-Genic Lineage Commitment of Human Mesenchymal Stem Cells

Human mesenchymal stem cells have a high potential in regenerative medicine. They can be isolated from a variety of adult tissues, including bone marrow, and can be differentiated into multiple cell types of the mesodermal lineage, including adipocytes, osteocytes, and chondrocytes. Stem cell differentiation is controlled by a process of interacting lineage-specific and multipotent genes. In this chapter, the authors use full genome microarrays to explore gene expression profiles in the process of Osteo-, Adipo-, and Chondro-Genic lineage commitment of human mesenchymal stem cells. DOI: 10.4018/978-1-4666-2506-8.ch004

[1]  H. Beug,et al.  The glucocorticoid receptor is a key regulator of the decision between self‐renewal and differentiation in erythroid progenitors , 1997, The EMBO journal.

[2]  O. MacDougald,et al.  The Role of C/EBP Genes in Adipocyte Differentiation* , 1998, The Journal of Biological Chemistry.

[3]  M. Pittenger,et al.  Multilineage potential of adult human mesenchymal stem cells. , 1999, Science.

[4]  R. Daverman,et al.  Extracellular Matrix Modulation of rhGDF-5-Induced Cellular Differentiation , 2000 .

[5]  J. Ntambi,et al.  Adipocyte differentiation and gene expression. , 2000, The Journal of nutrition.

[6]  W. Koo,et al.  Clinical responses to bone marrow transplantation in children with severe osteogenesis imperfecta. , 2001, Blood.

[7]  Min Zhu,et al.  Human adipose tissue is a source of multipotent stem cells. , 2002, Molecular biology of the cell.

[8]  J. Vermeesch,et al.  Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane , 2003, The Journal of cell biology.

[9]  Z. Estrov,et al.  Adult stem cells for tissue repair - a new therapeutic concept? , 2003, The New England journal of medicine.

[10]  R. Derynck,et al.  Transforming growth factor-beta inhibits adipocyte differentiation by Smad3 interacting with CCAAT/enhancer-binding protein (C/EBP) and repressing C/EBP transactivation function. , 2003, The Journal of biological chemistry.

[11]  J. Gimble,et al.  Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implications. , 2004, Current opinion in pharmacology.

[12]  A. Flake,et al.  Mesenchymal stem cells: paradoxes of passaging. , 2004, Experimental hematology.

[13]  R. Tuan,et al.  Distinct functions of BMP4 and GDF5 in the regulation of chondrogenesis , 2004, Journal of cellular biochemistry.

[14]  M. Hoshino,et al.  Bone Marrow Stromal Cells Generate Muscle Cells and Repair Muscle Degeneration , 2005, Science.

[15]  M. Knowles,et al.  Cell responses to FGFR3 signalling: growth, differentiation and apoptosis. , 2005, Experimental cell research.

[16]  J. Gimble,et al.  Playing with bone and fat , 2006, Journal of cellular biochemistry.

[17]  S. Farmer.  Transcriptional control of adipocyte formation. , 2006, Cell metabolism.

[18]  Xing Shen,et al.  Smad3-dependent nuclear translocation of beta-catenin is required for TGF-beta1-induced proliferation of bone marrow-derived adult human mesenchymal stem cells. , 2006, Genes & development.

[19]  E. R. van den Heuvel,et al.  Microarray analysis on Runx2-deficient mouse embryos reveals novel Runx2 functions and target genes during intramembranous and endochondral bone formation. , 2006, Bone.

[20]  Francesco Dell'Accio,et al.  Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis. , 2006, Arthritis and rheumatism.

[21]  D. Prockop,et al.  Clinical trials with adult stem/progenitor cells for tissue repair: let's not overlook some essential precautions. , 2007, Blood.

[22]  A. Giordano,et al.  From the laboratory bench to the patient's bedside: An update on clinical trials with mesenchymal stem cells , 2007, Journal of cellular physiology.

[23]  Giselle Chamberlain,et al.  Concise Review: Mesenchymal Stem Cells: Their Phenotype, Differentiation Capacity, Immunological Features, and Potential for Homing , 2007, Stem cells.

[24]  M. Pucéat.  TGFβ in the differentiation of embryonic stem cells , 2007 .

[25]  K. Frosch,et al.  Coexpression of osteogenic and adipogenic differentiation markers in selected subpopulations of primary human mesenchymal progenitor cells , 2008, Journal of cellular biochemistry.

[26]  T. He,et al.  A comprehensive analysis of the dual roles of BMPs in regulating adipogenic and osteogenic differentiation of mesenchymal progenitor cells. , 2009, Stem cells and development.

[27]  C. Pattichis,et al.  Quantitative Analysis of Hysteroscopy Imaging in Gynecological Cancer , 2009 .

[28]  A. Munnich,et al.  New Insight on FGFR3-Related Chondrodysplasias Molecular Physiopathology Revealed by Human Chondrocyte Gene Expression Profiling , 2009, PloS one.

[29]  Mathieu Roche,et al.  Information Retrieval in Biomedicine - Natural Language Processing for Knowledge Integration , 2009, Information Retrieval in Biomedicine.

[30]  Christian Gilissen,et al.  Osteo-transcriptomics of human mesenchymal stem cells: accelerated gene expression and osteoblast differentiation induced by vitamin D reveals c-MYC as an enhancer of BMP2-induced osteogenesis. , 2010, Bone.

[31]  S. Wakana,et al.  Id4, a New Candidate Gene for Senile Osteoporosis, Acts as a Molecular Switch Promoting Osteoblast Differentiation , 2010, PLoS genetics.

[32]  Shuanhu Zhou.  TGF‐β regulates β‐catenin signaling and osteoblast differentiation in human mesenchymal stem cells , 2011, Journal of cellular biochemistry.

[33]  Nader Zamani,et al.  Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure. , 2011, Endocrine reviews.

[34]  Agma J. M. Traina,et al.  Issues and Techniques to Mitigate the Performance Gap in Content-Based Image Retrieval Systems , 2011 .

[35]  Yousef Jasemian.  Sensing of Vital Signs and Transmission Using Wireless Networks , 2011 .

[36]  Spiridon D. Likothanassis,et al.  Mathematical Models of Dynamic Behavior of Individual Neural Networks of Central Nervous System , 2011, EANN/AIAI.

[37]  Case Study: Lessons Learned when Embedding Evidence-Based Knowledge in a Nurse Care Planning and Documentation System , 2011 .

[38]  Anthony E. Boitano,et al.  Small‐Molecule Regulators of Human Stem Cell Self‐Renewal , 2011, Chembiochem : a European journal of chemical biology.

[39]  Yufang Shi,et al.  How mesenchymal stem cells interact with tissue immune responses. , 2012, Trends in immunology.

[40]  Daniel Luis Notari,et al.  Dis2PPI: A Workflow Designed to Integrate Proteomic and Genetic Disease Data , 2012, Int. J. Knowl. Discov. Bioinform..

[41]  International Journal of Knowledge Discovery in Bioinformatics , 2022 .